[1]陈德新,菅莹莹,王瑜,等.丝氨酸蛋白酶-Corin在妊娠期高血压疾病中 应用的研究进展[J].中国计划生育和妇产科,2017,(1):24-28.
　CHEN De-xin,JIAN Ying-ying,WANG Yu,et al.Advances in the application of serine protease - Corin in hypertensive disorder complicating pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2017,(1):24-28.
点击复制

丝氨酸蛋白酶-Corin在妊娠期高血压疾病中 应用的研究进展
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年1期
页码:
24-28
栏目:
综述
出版日期:
2017-01-25

文章信息/Info

Title:
Advances in the application of serine protease - Corin in hypertensive disorder complicating pregnancy
作者:
陈德新1; 菅莹莹2; 王瑜2; 何荣霞1*
1. 730030甘肃兰州，兰州大学第二医院产科；2. 730030甘肃兰州，兰州大学第二临床医学院
Author(s):
CHEN De-xin1;  JIAN Ying-ying2; WANG Yu2; HE Rong-xia1*
1.Department of Obstetrics, The Second Hospital of Lanzhou University, Lanzhou Gansu 730030,P.R.China; 2. The Second Clinical Medical College of Lanzhou University, Lanzhou Gansu 730030, P.R.China
关键词:
妊娠期高血压疾病; 子痫前期; 丝氨酸蛋白酶; Corin ; 利钠肽
Keywords:
hypertensive disorder complicating pregnancy;  preeclampsia;  serin protease;  natriuretic peptide
摘要:
妊娠期高血压疾病在世界范围内长期对孕产妇及胎儿的健康及生命安全构成严重威胁，其发病机制至今仍不明确。近期的相关研究发现一种Ⅱ 型跨膜丝氨酸蛋白酶—Corin不仅主要分布在心脏，参与A型利钠肽和B型利钠肽的调节，而且也表达于妊娠期子宫。其对孕早期子宫螺旋小动脉重铸能否顺利进行有着重要的作用。而这一过程与妊娠期高血压疾病的发生有密切关系。本文主要从丝氨酸蛋白酶-Corin 的分子结构特征、组织分布、生物学功能等方面进行阐述，并对Corin 的基因缺陷或蛋白的缺乏是否与妊娠期高血压疾病存在相关性，以及可能的参与机制做一综述, 为该病的早期预测提供新的研究理论基础。
Abstract:
Hypertensive disorder complicating pregnancy (HDCP) poses a serious threat to maternal and fetal's health and life safety around the world for a long time.However,its pathogenesis is still unclear.Recent studies found aⅡtransmembrane serine protease - Corin which is mainly distributed in the heart, not only to participate in the regulation of A type natriuretic peptide (atrial natriuretic peptide,ANP) and B-type natriuretic peptide (brain natriuretic peptide,BNP) , but also expresses in the uterus during pregnancy.It plays an important role in the recasting of uterus spiral small arteries in early pregnancy.This process have a close relationship with the incidence of HDPC.This paper mainly expounds Corin characteristics of molecular structure, biological function, tissue distribution, which also introduces the correlation of Corin gene defect or protein deficiency with HDPC and possible mechanism of HDPC. This paper is likely to provide a new theoretical basis for the early prediction of the disease.

参考文献/References:

［1］谢幸，苟文丽妇产科学［M］北京：人民卫生出版社，2013：64-65 ［2］E.M. George, J.P. Granger. Recent insights into the pathophysiology of preeclampsia［J］, Expert Rev Obstet Gynecol ,2010,5(5):557–566. ［3］Kleinrouweler CE, Wiegerinck MM, Ris-Stalpers C, et al. Accuracy of circulating placental growth factor, vascular endothelial growth factor,soluble fms-like tyrosine kinase 1, and soluble endoglin in the prediction of pre-eclampsia: A systematic review and meta-analysis［J］.BJOG,2012,119(7):778–787. ［4］Cui Y, Wang W, Dong N, et al. Role of Corin in trophoblast invasion and uterine spiral artery remodeling in pregnancy［J］.Nature,2012,484(7393):246–250. ［5］G L G, KING S M, HOUNG A K. N-glycosylation modulates the cell-surf ace expressi on and catalytic activity of Corin［J］. Biochemical and Biophysical Research Communications, 2008, 373(1): 130-135. ［6］方朝东(综述),董宁征(审校).丝氨酸蛋白酶-Corin与心血管疾病［J］国际心血管病杂志，2011，38（2）：89-91 ［7］陈菲菲, 张驭涛, 刘莹,等. Corin-利钠肽系统与心血管疾病［J］. 中华心血管病杂志, 2015，43 (6)：478-483. ［8］JANSEN H J, ROSE R A. Natriuretic peptides:critical regulators of cardiac fibroblasts and the extracellular matrix in the heart［M］. Cardiac Fibrosis and Heart Failure: Cause or Effect?, 2015: 383-404. ［9］BHANDARI S S, DAVIES J E, STRUCK J, et al. The diagnostic performance of mid-regional portion of pro-atrial natriuretic peptide for the detection of left ventricular hypertrophy in Caucasian hypertensive patients［J］. Journal of Human Hypertension, 2012, 26(12): 711-715. ［10］BUCKLEY C L, STOKES A J. Corin-deficient W-sh mice poorly tolerate increased cardiac afterload［J］. Regulatory Peptides, 2011, 172(1/3): 44-50. ［11］WU F, YAN W, PAN J L, et al. Processing of pro-atrial natriuretic peptide by Corin in cardiac myocytes［J］. Journal of Biological Chemistry, 2002, 277(19): 16900-16905. ［12］CHAN J C, KNUD S O, WU F, et al. Hypertension in mice lacking the proatrial natriuretic peptide convertase Corin［J］. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(3): 785-790. ［13］GLADYSHEVA I P, ROBINSON B R, HOUNG A K, et al. Corin is coexpressed with pro-ANP and localized on the cardiomyocyte surface in both zymogen and catalytically active forms ［J］. Journal of Molecular and Cellular Cardiology, 2008, 44(1): 131-142. ［14］ICHIKI T, HUNTLEY B K, HEUBLEIN D M, et al. Corin is present in the normal human heart, kidney, and blood, with Pro-B-Type natriuretic peptide processing in the circulation［J］. Clinical Chemistry, 2011, 57(1): 40-47. ［15］DONG N, CHEN S, YANG J, et al. Plasma soluble Corin in patients with heart failure ［J］. Circulation-Heart Failure, 2010, 3(2): 207-211. ［16］DONG N, DONG J, LIU P, et al. Effects of an ticoagulants on human plasma soluble Corin levels measured by E LISA［J］. Clinica Chimica Acta, 2010, 411(23/24): 1998-2003. ［17］Wu F , Wu Q.Corin-mediated processing of pro-atrial natriuretic peptide in human small cell lung cancer cells［J］.Cancer Res , 2003 , 63 (23):8318-8322. ［18］Duvekot JJ, Cheriex EC, Pieters FA, et al. Early pregnancy changes in hemodynamics and volume homeostasis are consecutive adjustments triggered by a primary fall in systemic vascular tone［J］. Am J Obstet Gynecol,1993,169(169):1382–1392. ［19］LIU Yan, HU Jian-wei, YU Qian, et al. Increased serum soluble Corin in mid pregnancy is associated with hypertensive disorders of pregnancy ［J］. Journal of Women's Health, 2015, 24(7): 572-577. ［20］Khalil A, Maiz N, Garcia-Mandujano R, Elkhouli M,Nicolaides KH. Longitudinal changes in maternal Corin and mid-regional proatrial natriuretic peptide in women at risk of pre-eclampsia［J］. Ultrasound Obstet Gynecol,2015,45(2):190–198. ［21］Stepanian A, Alcaǐs A, de Prost D, et al. Highly significant association between two common single nucleotide polymorphisms in CORIN gene and preeclampsia in Caucasian women ［J］. PLoS One,2013,9(12):e113176. ［22］Rame JE , Tam SW, McNamara D , et al.Dysfunctional Corin i555(p568)allele is associated with impaired brain natriuretic peptide processing and adverse out comes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure sub study ［J］.Circ Heart Fail ,2009 , 2 (6):541-548. ［23］WANG W, LIAO X, FUKUDA K, et al. Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity［J］. Circulation Research, 2008, 103(5): 502-508. ［24］JC Chan, O Knudson, F Wu,et al.Hypertension in mice lacking the proatrial natriuretic peptide convertase Corin ［J］. Proc Natl Acad Sci USA,2005,102(3):785–790. ［25］BUJOLD E, MORENCY A M, ROBERGE S, et al. Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis ［J］. Journal of Obstetrics and Gynaecology Canada : JOGC, 2009, 31(9): 818-826. ［26］G Gerretsen, HJ Huisjes, JD Elema. Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation［J］. BJOG,1981,88(9): 876–881. ［27］KHONG T Y, DEWOLF F, ROBERTSON W B, et al. Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small for gestational age infants［J］. British Journal of Obstetrics and Gynaecology, 1986, 93(10): 1049-1059. ［28］R Pijnenborg, J Anthony, DA Davey, et al.Placental bed spiral arteries in the hypertensive disorders of pregnancy［J］. BJOG,1991,98(7): 648–655. ［29］L Macara, JC Kingdom, P Kaufmann, et al.Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical Doppler waveforms［J］. Placenta,1996,17 (1):37–48. ［30］SE Maynard, SA Karumanchi.Angiogenic factors and preeclampsia［J］. Semin Nephrol,2011,31(1): 33–46.

相似文献/References:

[1]宋改让,傅晓冬,刘华梅,等.IL-6、CRP在子痫前期中的意义[J].中国计划生育和妇产科,2009,(05):0.
　SONG Gai-rang,FU Xiao-dong,LIU Hua-meiThe department of gynaecology and obstetrics,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2009,(1):0.
[2]黄辉秀,谭毅.妊娠期高血压疾病预测和预防的研究现状[J].中国计划生育和妇产科,2009,(05):0.
　HUANG Hui-xiu,TAN Yi MCH Hospital of Fangcheng urban district,Fangchenggang city Guangxi automous region 80,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2009,(1):0.
[3]张珺,仲红丽.妊娠期高血压疾病监测系统预测及早期干预520例临床分析[J].中国计划生育和妇产科,2009,(06):0.
[4]肖兵,高岩,熊庆,等.妊娠期高血压疾病的流行病学研究进展[J].中国计划生育和妇产科,2010,(01):0.
[5]李延杰.早发型重度子痫前期妊娠116例结局分析[J].中国计划生育和妇产科,2010,(02):0.
　LI Yan-jie.[J].Chinese Journal of Family Planning & Gynecotokology,2010,(1):0.
[6]何怡,赵可文,唐莉,等.卡孕栓防治妊娠期高血压疾病产后出血的疗效观察[J].中国计划生育和妇产科,2010,(02):0.
　HE Yi,ZHAO Ke-wen,TANG LiMCH hospital of Dongguan city,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2010,(1):0.
[7]庞春蓉,傅晓冬.肾上腺髓质素与妊娠期高血压疾病[J].中国计划生育和妇产科,2010,(02):0.
[8]陈倩,段成城,傅晓冬,等.血清T辅助细胞比率与妊娠期高血压疾病的关系和意义[J].中国计划生育和妇产科,2010,(03):0.
　CHEN Qian,DUAN Cheng-cheng,FU Xiao-dong..[J].Chinese Journal of Family Planning & Gynecotokology,2010,(1):0.
[9]陈茜松,刘丽俊,季淑英,等.妊娠期高血压疾病患者血清抵抗素水平的变化及其临床意义[J].中国计划生育和妇产科,2011,(03):0.
　CHEN Qian-song,LIU Li-jun,JI Shu-ying.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(1):0.
[10]赵昆.D-二聚体测定在产科常见病理性高凝状态疾病的临床意义[J].中国计划生育和妇产科,2011,(04):0.
　ZHAO Kun.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(1):0.
[11]李力.子痫前期研究现状与思考[J].中国计划生育和妇产科,2014,(01):0.
　LI Li,Center of Gynecology and Obstetrics,Field Surgery Research.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(1):0.
[12]史梦丹,周容.妊娠期高血压疾病眼部变化[J].中国计划生育和妇产科,2016,(04):0.
[13]黄梦威,梅劼*.妊娠期高血压疾病孕产妇转诊问题探讨[J].中国计划生育和妇产科,2018,(4):17.
[14]李莹,伍绍文,陈奕*.妊娠期高血压疾病不良妊娠结局相关分析[J].中国计划生育和妇产科,2018,(9):43.
　LI Ying,WU Shao-wen,CHEN Yi*.Correlation analysis of adverse pregnancy outcomes of hypertensive disorder complicating pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2018,(1):43.
[15]程子怡,朱小辉,闫丽盈,等.妊娠合并多囊肾诊疗的围产结局分析[J].中国计划生育和妇产科,2020,(6):82.
　CHENG Ziyi,ZHU Xiaohui,YAN Liying,et al.Perinatal outcomes analysis of diagnosis and treatment of pregnancy with polycystic kidney[J].Chinese Journal of Family Planning & Gynecotokology,2020,(1):82.

更新日期/Last Update: 2017-01-25