[1]李穗湘.妊娠期糖尿病患者晚孕期血脂水平检测的临床意义[J].中国计划生育和妇产科,2017,(2):68-71.
　LI Sui-xiang.Clinical significance of serum lipids detection in patients with gestational diabetes mellitus[J].Chinese Journal of Family Planning & Gynecotokology,2017,(2):68-71.
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妊娠期糖尿病患者晚孕期血脂水平检测的临床意义
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年2期
页码:
68-71
栏目:
论著与临床
出版日期:
2017-02-25

文章信息/Info

Title:
Clinical significance of serum lipids detection in patients with gestational diabetes mellitus
作者:
李穗湘
广东深圳龙岗区第七人民医院
Author(s):
LI Sui-xiang
Department of Gynecology and Obstetrics，The Seventh People’s Hospital of Longgang District, Shenzhen Guangdong 518114,P.R.China
关键词:
妊娠期糖尿病; 血脂; 胰岛素敏感性; 炎症反应
Keywords:
gestational diabetes mellitus;  blood lipids;  insulin sensitivity;  inflammatory reaction
分类号:
R 714.256
摘要:
目的研究妊娠期糖尿病（gestational diabetes mellitus，GDM）患者晚孕期血脂水平检测的临床意义。方法选择2012年5月至2015年10月在深圳市龙岗区第七人民医院妇产科被确诊为GDM的孕晚期孕妇85例为观察组，同期待产的健康孕晚期孕妇100例为对照组，采集血清并测定血脂指标、血糖及血清胰岛素（insulin，INS）含量、炎性因子含量，计算胰岛素抵抗指数（homeostasis model assessment -insulin resistance index，HOMA-IR）和胰岛β细胞分泌指数（homeostasis model assessment –β，HOMA-β）。结果观察组患者总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度胆固醇（low density lipoprotein cholesterol，LDL-C)、载脂蛋白B（apolipoprotein B，ApoB）的含量明显高于对照组，高密度胆固醇(high density lipoprotein cholesterol ，HDL-C)、载脂蛋白A（apolipoprotein A，ApoA）的含量明显低于对照组（P<005）；INS含量、HOMA-IR均明显高于对照组，HOMA-β均明显低于对照组（P＜005）；血清C反应蛋白（C-reaction protein，CRP）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、白细胞介素-6 (interleukin-6，IL-6)、同型半胱氨酸（homocysteine，HCY)含量均明显高于对照组（P＜005）；血清TC、TG、LDL-C、ApoB含量与INS、CRP、TNF-α、IL-6、HCY的含量以及HOMA-IR呈正相关，与HOMA-β呈负相关(P＜005)；血清HDL-C、ApoA1的含量与INS、CRP、TNF-α、IL-6、HCY的含量以及HOMA-IR呈负相关，与HOMA-β呈正相关(P＜005)。结论GDM患者晚孕期血脂水平的检测不仅能够评估血脂代谢情况，还与胰岛素敏感性、全身炎症反应具有良好一致性。
Abstract:
ObjectiveTo study the clinical significance of serum lipids detection in patients with gestational diabetes mellitus（GDM）. Methods85 cases of pregnant women diagnosed GDM in the Seventh People’s Hospital of Shenzhen City Longgang District from May 2012 to October 2015 were enrolled in the observation group, 100 cases of healthy pregnant women received prenatal examination or waiting for delivery were enrolled in the control group. Serum was collected and blood lipid indexes, blood glucose and serum insulin(INS) levels, inflammatory factor contents were determined, homeostasis model assessment insulin resistance index(HOMA-IR) and HOMA-β were calculated. ResultsSerum total cholesterol(TC),triglyceride(TG), low density lopoprotein cholesterol(LDL-C), apolipoprotein B(ApoB) level of observation group were significanlty higer than that of control group, HDL-C, ApoA1 level were significantly lower than that of control group（P＜005）; Serum INS, HOMA-IR were significantly higher than that of control group, HOMA-β were significantly lower than that of control group（P<005）, Serum C-reaction protein(CRP), TNF-α, IL-6, HCY level were significanlty higher than that of control group（P＜005）; Serum TC, TG, LDL-C, ApoB contents positively correlated with CRP, TNF-α, IL-6, HCY levels and HOMA-IR, negatively correlated with HOMA-β (P＜005).; serum HDL-C, ApoA1 levels negatively correlated with CRP, TNF-α, IL-6, HCY levels and HOMA-IR, positively correlated with HOMA-β(P＜005).Conclusionthe detection of serum lipids in patients with GDM is not only able to assess lipid metabolism, but also has good consistency with insulin sensitivity and systemic inflammatory response.

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更新日期/Last Update: 2017-02-25