[1]康媛媛,邢军*,周剑利,等.妊娠期糖尿病孕妇口服75g葡萄糖耐量试验不同时点血糖异常对新生儿并发症及神经行为发育的影响[J].中国计划生育和妇产科,2016,(12):44- 46,50.
　KANG Yuan-yuan,XING Jun*,ZHOU Jian-li,et al.The effects of abnormal blood glucose of 75g OGTT in pregnant women with gestational diabetes mellitus on neonatal complications and neurobehavioral development[J].Chinese Journal of Family Planning & Gynecotokology,2016,(12):44- 46,50.
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妊娠期糖尿病孕妇口服75g葡萄糖耐量试验不同时点血糖异常对新生儿并发症及神经行为发育的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2016年12期
页码:
44- 46,50
栏目:
论著与临床
出版日期:
2016-12-30

文章信息/Info

Title:
The effects of abnormal blood glucose of 75g OGTT in pregnant women with gestational diabetes mellitus on neonatal complications and neurobehavioral development
作者:
康媛媛; 邢军*; 周剑利; 温洁; 赵楠楠; 宋爽
华北理工大学附属医院
Author(s):
KANG Yuan-yuan; XING Jun*; ZHOU Jian-li; WEN Jie; ZHAO Nan-nan; SONG Shuang
North China University of Science and Technology Affiliated Hospital，Tangshan Hebei 063004，P.R.China
关键词:
妊娠期糖尿病; 糖耐量试验; 新生儿并发症; 神经行为
Keywords:
gestational diabetes mellitus; oral glucose tolerance test; neonatal complication; neurological behavior
分类号:
R 714256
摘要:
目的分析妊娠期糖尿病(gestational diabetes mellitus, GDM)孕妇75g葡萄糖耐量试验(oral glucose tolerance test,OGTT)不同时点血糖异常对新生儿并发症及神经行为发育的影响。方法选取2015年10月至2016年4月在华北理工大学附属医院规律产检并住院分娩的GDM孕妇所生144例新生儿作为研究对象，其中孕妇75g OGTT 1项时点血糖异常为 GDMⅠ组、2 项时点血糖异常为GDMⅡ组、3 项时点血糖均异常为GDMⅢ组；分别对3组孕妇的新生儿进行新生儿行为神经测定（neonatal behavioral neurological assessment,NABA）评分。结果① 3组NABA评分相比较，GDMⅢ组低于GDMⅡ组和GDMⅠ组，且两两比较差异有统计学意义（P＜005）。② 3组新生儿低血糖的发生率分别为52 %、62 %、230 %；巨大儿的发生率分别为52 %、187 %、333 %，组间比较差异均有统计学意义(P<005)。③ 3组中，新生儿低血糖者NABA低于血糖正常者；巨大儿NABA评分低于非巨大儿。结论75g OGTT异常时点越多，新生儿神经行为发育损伤及新生儿低血糖、巨大儿的发生率也越高。因此对不同层次的高危孕妇及新生儿应尽早采取不同的措施以改善不良预后。
Abstract:
ObjectiveTo analyze the effects of abnormal blood glucose of 75g oral glucose tolerance test(OGTT) in pregnant women with gestational diabetes mellitus(GDM) on neonatal complications and neurobehavioral development. MethodsA total of 144 newborns were selected as the observation group, whose mothers were diagnosed as GDM and received prenatal examination and delivered in North China University of Science and Technology Affiliated Hospital from October 2015 to April 2016.The pregnant women were divided into 3 groups on the basis of each time point blood glucose results in 75g OGTT. Group GDMⅠ:one abnormal blood glucose of OGTT result. Group GDMⅡ:two abnormal blood glucose of OGTT results and Group GDMⅢ:three abnormal blood glucose results.The neonatal behavioral neurological assessment （NABA） score of newborns of the 3 groups of pregnant women were analyzed respectively．Results ①Comparison of NABA scores in the 3 groups,GDMⅢ was lower than GDMⅡand GDMⅠ,and pairwise comparison were different significantly (P<005); ②The incidence of neonatal hypoglycemia in the 3 groups were 52%, 62% and 230% The incidence of macrosomia were 52%，187% and 333%. The differences were statistically significant(P<005). ③In the 3 groups,the NABA score of neonatal hypoglycemia was lower than that of the normal blood glucose. The NABA score of macrosomia was lower than that of normal. ConclusionThe more OGTT abnormal points,the higher the incidence rate of neonatal neurological behavioral development injury， neonatal hypoglycemia and macrosomia. Therefore, different levels of high-risk pregnant women and newborns should take different measures as early as possible to prevent the poor prognosis．

参考文献/References:

［1］刘伟，朱晓勇，金莉萍．妊娠期糖尿病发病相关因素的研究进展 ［J］．现代妇产科进展，2014，23（4）：308-310． ［2］孙翀，刘淑霞．妊娠期糖尿病患者血糖控制效果对母婴结局影响的观察 ［J］．中国糖尿病杂志，2014，22（5）：401-403． ［3］张晓，周剑利，邢军，等．妊娠期糖尿病 75g OGTT 不同时点血糖异常孕妇的临床特点与妊娠结局分析 ［J］．现代妇产科进展杂志，2016，25（4）：265-268． ［4］American Diabetes Association. 2011 Standards of medical carein diabetes ［D］．Diabetes Care，2011，34：S11-S61． ［5］罗静，常青，王延洲，等．新妊娠期糖尿病诊断标准与围生期母儿结局分析 ［J］．实用妇产科杂志，2012，28（9）：755-758． ［6］邵肖梅．新生儿低血糖及低血糖脑损伤 ［J］．实用医院临床杂志，2009，6（6）：5-7． ［7］黄德芳，刘党英．糖化血红蛋白 GSP 及CRP测定在妊娠期糖尿病中的应用 ［J］．浙江临床医学，2014，16（7）：1150-1151． ［8］Shriraam V，Ｒani MA，Sathiyasekaran BW，et al．Awareness of gestational diabetes mellitus among antenatal women in a primary health center in South India ［J］. Indian Journal of Endocrinology & Metabolism，2013，17（1）：146-148. ［9］雷琼，牛建民，段冬梅，等．妊娠中期脂代谢异常与不良妊娠结局的相关性 ［J］．中华围产医学杂志，2014，17（8）：527-530． ［10］Colatrella A，Visalli N，Abbruzzese S，et al．Comparison of insulin lispro protamine suspension with NPH insulin in pregnant women with Type 2 and gestational diabetes mellitus: maternal and perinatal outcomes ［J］. International Journal of Endocrinology，2013（3）：184-194． ［11］Hernandez HR，Castillo MN，Banda TME，et al ．Hypoglycemia in the newborns of women with diabetes mellitus ［J］. Rev Invest Clin，2006，58（4）：285-288.

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更新日期/Last Update: 2016-12-25