[1]颜露春,范可心,叶蔚*.妊娠期合并静脉血栓栓塞性疾病的危险因素及临床特点分析[J].中国计划生育和妇产科,2017,(4):30-33.
　YAN Lu-chun,FAN Ke-xin,YE Wei*.Risk factors and clinical characteristics of pregnancy complicated with venous thromboembolism[J].Chinese Journal of Family Planning & Gynecotokology,2017,(4):30-33.
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妊娠期合并静脉血栓栓塞性疾病的危险因素及临床特点分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年4期
页码:
30-33
栏目:
论著与临床
出版日期:
2017-04-25

文章信息/Info

Title:
Risk factors and clinical characteristics of pregnancy complicated with venous thromboembolism
作者:
颜露春; 范可心; 叶蔚*
广东医科大学附属医院妇产科
Author(s):
YAN Lu-chun ; FAN Ke-xin; YE Wei*
Department of Gynaecology and Obstetrics,The Affiliated Hospital of Guangdong Medical University ,Zhanjiang Guangdong, 524001,P.R.China.
关键词:
妊娠;  深静脉血栓栓塞性疾病; 危险因素
Keywords:
pregnancy;  deep venous thromboembolism disease;  risk factors
分类号:
R 714.252
摘要:
目的分析妊娠期合并静脉血栓栓塞性疾病（venous thromboembolism ，VTE）的危险因素及临床特点。方法将1995~2015年广东医科大学附属医院收治的妊娠期合并VTE的患者48例作为VTE组，并将其根据发病孕周分为3个亚组（<12周组14例，12周～28周组17例，>28周组17例）；采用1：2配比病例对照分析的方法，选择同期产检、住院分娩且无产科合并症与并发症的正常孕妇96例为对照组。采用logistic回归分析方法比较两组产检及住院分娩的病历资料。结果① VTE组孕次多于对照组、体重增长幅度大于对照组，红细胞（erythrocyte，RBC）、血红蛋白（hemoglobin，Hb）、血红蛋白压积（hematocrit，HCT）低于对照组，差异均有统计学意义(P<005)；② 凝血酶原时间(prothrombin time，PT）、活化部分凝血活酶时间(activated partial thromboplastin time，APTT）、D-二聚体（D-Dimer）、纤维蛋白原(fibrinogen，FIB）水平比较差异无统计学意义（P>005）；③ VTE亚组分析发现：随着孕周的增加，RBC、HB、HCT、PT、APTT等指标均有下降趋势，D-Dimer、FIB均有升高趋势，但不同亚组间两两比较差异无统计学意义（P>005）；④ 单因素分析结果显示：孕次，体重增长幅度，Hb、HCT、RBC低，稽留流产病史，妊娠期高血压疾病是VTE形成的危险因素。多因素回归分析结果显示：稽留流产病史是VTE发病的独立危险因素。结论稽留流产病史是妊娠期合并VTE发病的独立危险因素之一，而妊娠期的Hb、HCT、RBC减低对于VTE的发生可能具有早期预测价值。
Abstract:
ObjectiveTo analyze the risk factors and clinical characteristics of pregnancy complicated with venous thromboembolism(VTE). Methods48 patients with VTE from 1995 to 2015 in the Affiliated Hospital of Guangdong Medical University were enrolled as VTE group and divided into three subgroups according to the onset of gestational age (14 cases in <12 weeks group , 17 cases in 12～28 weeks group and 17 cases in > 28 weeks group); A total of 96 cases of normal pregnant women with homemade test, hospital delivery and no obstetric complications and complications were selected as the control group by 1: 2 ratio of case - control analysis.Logistic regression analysis was used to compare clinical data of the two groups. Results① The erythrocyte(RBC), hemoglobin(Hb) and hematocrit(HCT) of VTE group were higher than those of the control group,and the difference was statistically significant(P<005);② There were no significant differences in the levels of prothrombin time(PT), activated partial thromboplastin time(APTT), D-dimer and fibrinogen(FIB)(P>005);③ VTE subgroup analysis showed that RBC, HB, HCT, PT and APTT decreased with the increase of gestational age, while D-dimer and FIB increased.But there were no statistical differences between different subgroups(P>005); ④ Univariate analysis showed that pregnancy, body mass index, Hb, HCT, RBC, history of missed abortion and hypertensive disorder complicating pregnancy were the risk factors of VTE. Multivariate regression analysis showed that history of missed abortion was an independent risk factor for VTE. ConclusionHistory of missed abortion is one of the independent risk factors for VTE during pregnancy, while the reduction of Hb, HCT and RBC in pregnancy may have an early predictive value for VTE.

参考文献/References:

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更新日期/Last Update: 2017-04-25