[1]刘媛媛*,李莉,鲁翠萍.先兆早产患者应用抗生素的必要性研究[J].中国计划生育和妇产科,2017,(3):57-60.
　LIU Yuan-yuan*,LI Li,LU Cui-ping.Study on the necessity of applying antibiotics in patients with threatened preterm labor[J].Chinese Journal of Family Planning & Gynecotokology,2017,(3):57-60.
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先兆早产患者应用抗生素的必要性研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年3期
页码:
57-60
栏目:
论著与临床
出版日期:
2017-03-25

文章信息/Info

Title:
Study on the necessity of applying antibiotics in patients with threatened preterm labor
作者:
刘媛媛*; 李莉; 鲁翠萍
广东省深圳市龙华新区人民医院产二科
Author(s):
LIU Yuan-yuan*;  LI Li;  LU Cui-ping
Department of Obstetrics, People’s Hospital of Longhua New District, Shenzhen Guangdong 518109，P.R.China
关键词:
先兆早产; 抗生素; 利托君; 联合疗法
Keywords:
preterm labor;  antibiotics;  ritodrine;  combination therapy
分类号:
R 71421
摘要:
目的探讨先兆早产患者应用抗生素的必要性，为临床治疗先兆早产提供理论基础。方法选择2012年5月至2013年2月在深圳市龙华新区人民医院就诊的150例单胎妊娠先兆早产病例，所有病例按随机数字表法分为3组：利托君组、抗生素组、联合利托君及抗生素组，每组各50例，分别给予干预措施后，监测入选病例血常规、记录延长妊娠的时间、检测相关炎症因子水平、宫颈细菌培养。结果患者阴道内分泌物进行细菌培养后，确认存在致病菌者81例，培养致病菌菌株96株。其中大肠杆菌24株，金黄色葡萄球菌21株，表皮葡萄球菌16株，阴沟肠杆菌14株，屎肠球菌15株，其他细菌6株。阴道寄生菌群对万古霉素、亚胺培南和阿米卡星等药物耐药性较差，在改善炎性介质肿瘤坏死因子-α、白细胞介素-10和金属蛋白酶-3方面，联合治疗组具有明显优势。单独使用利托君、抗生素均可有效增加孕龄、婴儿出生体重和Apgar评分，联合治疗组治疗效果更为明显。 结论抗生素可有效延长妊娠时间，故先兆早产患者有必要运用抗生素以提高母婴生存质量。
Abstract:
ObjectiveTo explore the necessity of applying antibiotics in patients with threatened preterm labor, and to provide theoretical basis for clinical treatment of threatened preterm labor. Methods150 cases of singleton pregnancy threatened preterm labor from May 2012 to February 2013 in Department of Obstetrics, People’s Hospital of Longhua New District were selected, all cases were divided into three groups by random number table with 50 cases in each group: ritodrine group, antibiotic group, joint ritodrine and antibiotic group. Inflammatory factors levels and cervical bacteria culture were detected after intervention respectively, monitored routine blood test and calculated the extended time of pregnancy. ResultsAfter the bacterial culture of patients’ vaginal secretions, there were 81 pathogenic bacteria and 96 strains of pathogenic bacteria. Including 24 strains of escherichia coli; 21 strains of staphylococcus aureus; 16 strains of staphylococcus epidermidis; 14 strains of enterobacter cloacae; 15 strains of enterococcus faecium and 6 other bacteria strains. Drug resistance of vaginal bacteria to vancomycin, imipenem and amikacin was poor.In the improvement of inflammatory mediators TNF-α, IL-10 and MMP-3, the combination therapy group has obvious advantages. The use of ritodrine or antibiotics alone can effectively increase the gestational age, infant birth weight and Apgar score, while therapeutic effect of the combined treatment group was more obvious. ConclusionAntibiotics can effectively extend the time of pregnancy, so it is necessary to use antibiotics to improve the quality of life in patients with threatened premature labor.

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备注/Memo

备注/Memo:
深圳市宝安区科技计划—社会公益立项项目（项目编号：2012242）
更新日期/Last Update: 2017-03-25