[1]郭宗艳,宋向凤*.母亲孕前肥胖对子代免疫球蛋白及补体变化的影响[J].中国计划生育和妇产科,2017,(4):48-51.
　GUO Zong-yan,SONG Xiang-feng*.Effects of pre-pregnancy obesity on offspring immunoglobulin and complement[J].Chinese Journal of Family Planning & Gynecotokology,2017,(4):48-51.
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母亲孕前肥胖对子代免疫球蛋白及补体变化的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年4期
页码:
48-51
栏目:
论著与临床
出版日期:
2017-04-25

文章信息/Info

Title:
Effects of pre-pregnancy obesity on offspring immunoglobulin and complement
作者:
郭宗艳1; 宋向凤2*
1. 454000河南焦作 ，焦作市人民医院产科；2. 453000河南新乡，新乡医学院基础医学院免疫教研室
Author(s):
GUO Zong-yan1; SONG Xiang-feng2*
1.Department of Obstetrics,Jiaozuo People’s Hospital,Jiaozuo Henan 454000,P.R.China;2. Basic Medical Teaching and Research Section, Xinxiang Medical College, Xinxiang Henan 453000, P.R.China
关键词:
孕前肥胖; 新生儿; 免疫球蛋白; 补体; 出生体质量
Keywords:
pre-pregnancy obesity;  neonatal;  immunoglobulin;  complement;  birth weight
分类号:
R 714.14+7
摘要:
目的通过对肥胖妇女妊娠期及其所生婴儿免疫球蛋白（immuno globulin，Ig）、补体（complement，C）、婴儿体质量进行分析，研究其相关性，探讨肥胖对生育期女性及新生儿免疫的影响。方法选取2015年9月至2016年4月在焦作市人民医院产前检查并分娩的20～40岁、孕周37～42周的产妇92例，根据孕前体质量指数（body mass index ，BMI）分为正常组（BMI 185～239 kg/m2）55例和肥胖组（BMI≥240 kg/m2，包括超重、肥胖）37例。采集孕妇与新生儿静脉血并登记新生儿出生体质量，血标本分离血清后24 h内用免疫比浊法检测IgG、IgA、IgM、C3、C4。结果肥胖组母亲的新生儿平均体质量高于正常组（P＜005），肥胖组母亲分娩巨大儿的比例高于正常组（P＜005），孕前BMI与新生儿出生体质量呈正相关（P＜005）。肥胖组母亲血清IgG、IgA、IgM低于正常组，C3较正常组升高（P均＜005）。肥胖组新生儿血清IgA、IgM低于正常组（P＜005），孕前BMI与子代血清IgA、IgM呈负相关（P＜005）。结论孕前超重或肥胖可增加巨大儿的出生率；孕前超重或肥胖母亲自身血清免疫球蛋白IgG、IgA、IgM和补体C3处于异常，可影响新生儿的免疫球蛋白和补体水平。
Abstract:
Objective To analyze immune globulin (Ig) ,complement (C) and body mass index(BMI) of obese women during pregnancy and their newborns ,to study the correlation, and to explore the effect of obesity on female and neonatal immunity in the reproductive period. Methods92 pregnant women in Jiaozuo People’s Hospital from September 2015 to April 2016 were chosen. They were from 20 to 40 years old and 37 to 42 weeks of pregnancy. According to BMI before pregancy,they were divided into normal group(BMI 185～239 kg/m2) and obese group(BMI≥240 kg/m2). Venous blood of the pregnant women and neonatal were collected and BMI of the newborns were registered. The levels of IgG, IgA, IgM, C3 and C4 were detected by immune turbidimetric method within 24 h after separation of blood samples.Recorded the body weight. IgA, IgM, C3, C4 and IgG of blood samples were detected by immune turbidity method in 24 hours. ResultsThe newborns′ BMI and large infants ratio of obese group were higher than normal group(P＜005).The mother’s pre-pregnancy BMI was positively related to the birth weight(P＜005).The serum levels of IgG, IgA, IgM in obese group were significantly lower than that in normal group,with C3 as the opposite(P＜005). The serum levels of IgA and IgM in the newborns of obese group were lower than that in the normal group(P＜005). The pre-pregnancy BMI was negative related to the levels of serum IgA and IgM in offspring. Conclusions① Pre-pregnancy overweight or obesity may increase the birth rate of macrosomia.② The serum levels of IgG, IgA, IgM and complement C3 were abnormal in overweight or obese mother pre-pregnancy, which could affect the immunoglobulin and complement levels in neonates.

参考文献/References:

［1］Gregor MF，Hotamisligil GS. Inflammatory mechanisms in obesity ［J］. Annu Rev Immunol，2011，29：415-445. ［2］夏亚娣，方雅琴，孙芸，等．孕前体质量指数对妊娠结局影响的系统评价 ［J］．浙江创伤外科，2015，20 （4）：626-630． ［3］崔妍．肥胖症及其相关并发症的临床研究以及肥胖症患者不同糖代谢状态下血清相关因子变化的研究 ［D］．北京：北京协和医学院/清华大学医学部/中国医学科学院，2013． ［4］王熙蓓，杨文亮，田德红，等．中国儿童单纯性肥胖与出生体重关系的Meta分析 ［J］．中国儿童保健杂志，2015，23 （10）：1077-1080． ［5］曹雪涛．医学免疫学 ［M］．北京：人民卫生出版社，2013：2-3． ［6］李霞，孙正芸，范秀芳，等．妊娠期糖尿病对新生儿免疫球蛋白、补体的影响 ［J］．中国妇幼保健，2012，27 （4）：544-546． ［7］何源，杨树杰，唐艳林，等．妊娠期糖尿病母亲新生儿早期免疫球蛋白及补体测定 ［J］．中国生育健康杂志，2012，23（2）：96-97, 104．

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更新日期/Last Update: 2017-04-25