[1]刘素华*,赵阳阳,訾苹苹,等.肝素对复发性流产患者凝血功能、并发症及妊娠结局的影响[J].中国计划生育和妇产科,2017,(5):44-47.
　LIU Su-hua*,ZHAO Yang-yang,ZI Ping-ping,et al.Effect of heparin on coagulation function, complication and pregnancy outcome in patients with recurrent spontaneous abortion[J].Chinese Journal of Family Planning & Gynecotokology,2017,(5):44-47.
点击复制

肝素对复发性流产患者凝血功能、并发症及妊娠结局的影响
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年5期
页码:
44-47
栏目:
论著与临床
出版日期:
2017-05-25

文章信息/Info

Title:
Effect of heparin on coagulation function, complication and pregnancy outcome in patients with recurrent spontaneous abortion
作者:
刘素华*; 赵阳阳; 訾苹苹; 张秋菊
禹城市人民医院妇产科
Author(s):
LIU Su-hua*; ZHAO Yang-yang; ZI Ping-ping; ZHANG Qiu-ju
Department of Gynaecology and Obstetrics， People 's Hospital of Yucheng，Yucheng Shandong 251200，P.R.China
关键词:
复发性流产; 肝素; 凝血功能; 妊娠结局
Keywords:
recurrent abortion;  heparin;  blood coagulation function;  pregnancy outcome
分类号:
R 71421
摘要:
目的探讨肝素治疗对复发性流产(recurrent spontaneous abortion,RSA )患者凝血功能、并发症及妊娠结局的影响。方法选取2014年1月至2016年1月在禹城市人民医院治疗的RSA患者100例，将患者分为观察组和对照组各50例，其中对照组予黄体酮、人绒毛膜促性腺激素治疗，观察组在对照组的基础上给予肝素治疗，比较两组治疗前后纤维蛋白原(fibrinogen，FIB)、部分凝血酶原时间(activated partial thromboplastin time，APTT)、血浆组织型
Abstract:
ObjectiveTo investigate effect of heparin on coagulation function, complications and pregnancy outcome in patients with recurrent spontaneous abortion（RSA）. Methods100 cases of RSA treated in People 's Hospital of Yucheng from Jan.2014 to Jan.2016 were selected, and they were randomly divided into observation group and control group according to random number table method, each group of 50 cases. The control group was given progesterone, human chorionic gonadotropin（hCG） treatment, observation group received heparin on the basis of the control group, observed pregnancy outcome and complications of two groups, including fibrinogen (FIB), activated partial thromboplastin time(APTT), plasma tissue-type plasminogen activator(t-PA) factor and plasminogen activator inhibitor-1(PAI-1) before and after treatment. ResultsAPTT,FIB,PAI-1and t-PA of the two groups had no difference before treatment（P＞005）, and APTT of the two groups had no significant difference after treatment（P＞005）, FIB and PAI-1 decreased after treatment in observation group, while t-PA increased (P<005). FIB and PAI-1 had no significant difference after treatment in control group, while t-PA decreased (P<0.05). After treatment, FIB and PAI-1 in observation group was significantly lower than that in control group, and t-PA was significantly higher than that in control group (P<005); The casese of thrombocytopenia, ecchymosis and total complication had decreased in observation group, compared with control group (P<005). ConclusionHeparin has a good effect in treatment of RSA by improving the patients' blood coagulation state.

参考文献/References:

［1］刘志兰，康晓敏，张晓欣，等．复发性自然流产1 101例病因分析 ［J］．上海交通大学学报（医学版），2015，22（3）：396-401． ［2］杨素娟，赵志明，王玮，等．主动免疫治疗原因不明复发性流产1 005例疗效评价 ［J］．实用妇产科杂志，2016，32（4）：311-313． ［3］胡海波，肖苑玲，黎金颜，等．低分子肝素在先兆流产中的应用 ［J］．广东医学，2014，25（8）：1253-1254． ［4］王敬华，张弘．不明原因复发性流产患者凝血功能状态观察 ［J］．山东医药，2016，56（2）：82-83． ［5］中华医学会妇产科学分会产科学组．复发性流产诊治的专家共识 ［J］．中华妇产科杂志，2016，22（1）：3-9． ［6］朱薏．低分子肝素联合主动免疫治疗不明原因复发性自然流产的效果 ［J］．实用医学杂志，2015，25（5）：793-795． ［7］李维宏，牟晓玲．黄体酮保胎治疗对不明原因复发性流产患者外周血辅助性T淋巴细胞17/调节性T淋巴细胞免疫失衡的影响研究 ［J］．中国全科医学，2015，18（36）：4444-4449． ［8］HONG Y, XIE Q-x, CHEN C-y, et alInsulin resistance in first-trimester pregnant women with pre-pregnant glucose tolerance and history of recurrent spontaneous abortion ［J］. Journal of Biological Regulators and Homeostatic Agents, 2013, 27(1): 225-231. ［9］乔娟，张园，钟梅．低分子肝素在子痫前期和复发性流产中的应用进展 ［J］．实用医学杂志，2013，25（12）：1894-1896． ［10］马丽娜，徐永萍，李苏，等．低分子肝素对抗子宫内膜抗体环境中滋养细胞增殖与凋亡能力的调节作用 ［J］．现代妇产科进展，2011，20（4）：253-256． ［11］穆雅琴，朱壮彦，郭俊成，等．乙酰肝素酶在人类妊娠过程中的作用研究 ［J］．中国妇幼保健，2013，28（8）：1306-1308． ［12］梁蓉，刘淑芳，黄玉珍，等．阿司匹林联合低分子肝素治疗复发性流产给药时间、剂量临床研究 ［J］．中国现代药物应用，2016，10（8）：114-115． ［13］魏军，王艳红，蒋金辉，等．小剂量肝素对脓毒症患者凝血功能及血小板活化水平影响 ［J］．现代仪器与医疗，2015，25（6）：10-12． ［14］VON TEMPELHOFF G F, SCHELKUNOV O, DEMIRHAN A, et al.Thrombelastometric results and platelet function during pregnancy in women receiving low molecular weight heparin with a history of recurrent/late abortion——A retrospective analysis ［J］. Clinical Hemorheology and Microcirculation, 2015, 61(1): 99-110. ［15］NAZARI Z, GHAFFARI J, EBADI A. Comparison of the effect of aspirin and heparin with or without intravenous immunoglobulin in treatment of recurrent abortion with unknown etiology: A clinical study ［J］. Journal of Natural Science, Biology, and Medicine, 2015, 6(Suppl 1): S17-S21. ［16］OZBILGIN K, KARACA F, TURAN A, et al. The higher heparin-binding epidermal growth factor (HB-EGF) in missed abortion ［J］. Taiwanese Journal of Obstetrics & Gynecology, 2015, 54(1): 13-18.

相似文献/References:

[1]雷贞武.各种先天性子宫异常与复发性流产的临床问题[J].中国计划生育和妇产科,2009,(06):0.
[2]万波,颜友良,胡文娟,等.心理干预与复发性流产妊娠结局的研讨[J].中国计划生育和妇产科,2013,(01):0.
　WAN Bo,YAN You-liang*,HU Wen-juan,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2013,(5):0.
[3]李树侠,张弘,陈昕,等.宫腔镜检查在复发性流产患者诊治中的作用[J].中国计划生育和妇产科,2013,(05):0.
　LI Shu-xia,ZHANG Hong,CHEN Xin,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2013,(5):0.
[4]庞小艳,邓小清,肖翠艳,等.复发性流产患者清宫术中个性化护理的临床观察[J].中国计划生育和妇产科,2014,(08):0.
　PANG Xiao-yan,DENG Xiao-qing,XIAO Cui-yan,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(5):0.
[5]廖红玉.阿司匹林联合地塞米松孕前干预D2聚体升高型复发性流产的疗效分析[J].中国计划生育和妇产科,2015,(07):0.
　LIAO Hong-yu,[J].Chinese Journal of Family Planning & Gynecotokology,2015,(5):0.
[6]康丹阳,杨巧妮,乔宠*.应用血栓弹力图监测不同流产次数的复发性流产患者凝血功能变化情况[J].中国计划生育和妇产科,2017,(2):22.
　KANG Dan-yang,YANG Qiao-ni,QIAO Chong*.Application of thrombelastography to monitor the change of coagulation function in patients of recurrent spontaneous abortion in different times[J].Chinese Journal of Family Planning & Gynecotokology,2017,(5):22.
[7]杨纨,王海燕*.多囊卵巢综合征与复发性流产[J].中国计划生育和妇产科,2017,(10):1.
[8]罗云瑶,程冉,许良智*.复发性流产与染色体相关因素的研究进展[J].中国计划生育和妇产科,2017,(10):7.
[9]欧玉华,张建平*.低分子肝素在复发性流产中应用的现状研究[J].中国计划生育和妇产科,2017,(10):10.
[10]刘佩玲,赵金霞,刘湘源*.细胞因子与复发性流产的相关性研究进展[J].中国计划生育和妇产科,2017,(10):16.

更新日期/Last Update: 2017-05-25