[1]陈秋玲*,李文霞,简珊.单核细胞趋化蛋白-1在胎儿生长受限患者胎盘的表达及其意义[J].中国计划生育和妇产科,2017,(4):41-44.
　CHEN Qiu-ling*,LI Wen-xia,JIAN Shan.Expression of monocyte chemoattractant protein-1 in placenta of patients with fetal growth restriction and its significance[J].Chinese Journal of Family Planning & Gynecotokology,2017,(4):41-44.
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单核细胞趋化蛋白-1在胎儿生长受限患者胎盘的表达及其意义
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年4期
页码:
41-44
栏目:
论著与临床
出版日期:
2017-04-25

文章信息/Info

Title:
Expression of monocyte chemoattractant protein-1 in placenta of patients with fetal growth restriction and its significance
作者:
陈秋玲1*; 李文霞1; 简珊2
1. 410007湖南长沙，长沙市妇幼保健院产科；2. 554300贵州铜仁，铜仁市妇幼保健院妇产科
Author(s):
CHEN Qiu-ling1*;  LI Wen-xia1;  JIAN Shan2
1. Department of Obstetrics,Changsha Maternal and Child Healthcare Hospital,Changsha Hunan 410007,P.R.China;2. Department of Obstetrics,Tongren Maternal and Child Healthcare Hospital,Tongren Guizhou 554300, P.R.China
关键词:
单核细胞趋化蛋白-1; 胎儿生长受限; 绒毛炎
Keywords:
monocyte chemoattractant protein - 1;  fetal growth restriction;  placental;  chorioamnionitis
分类号:
R 7143
摘要:
目的通过检测胎儿生长受限（fetal growth restriction,FGR）患者胎盘、外周血中单核细胞趋化蛋白-1（monocyte chemoattractant protein - 1，MCP-1）的表达水平，探讨MCP-1在FGR中的作用及可能机制。方法选择50例FGR患者为FGR组，正常晚期妊娠分娩孕妇50例为正常对照组，以酶联免疫吸附法检测两组孕妇胎盘、外周血MCP-1水平，并对胎盘组织切片进行病理形态学分析。结果FGR组胎盘光镜下见不同程度的绒毛发育不良，合体结节增多，绒毛炎，其发生率高于正常对照组［640 %(32/50) vs 120 %(6/50),P<005］,其中合并绒毛炎的发生率31%（10/32）；FGR组中胎盘病理异常组的胎盘MCP-1浓度高于正常对照组，差异有统计学意义［胎盘MCP-1: (13697±1024) vs（12976±567）ng/mL,P<005］,其中合并绒毛炎胎盘中MCP-1浓度高于正常对照组［(14976±867)vs(12976±567)ng/mL,P<005］；而FGR组中胎盘病例异常组与正常对照组外周血MCP-1浓度比较差异无统计学意义［血清MCP-1 (13714±973) vs(14016±1034) ng/mL,P＞005］。结论MCP-1参与了FGR的发生，其作用机制可能通过过度炎症反应，导致胎盘灌注不足。
Abstract:
ObjectiveTo research the serum and placental expression of monocyte chemoattractant protein–1(MCP-1) in fetal growth restriction（FGR）,and analyze their effect and mechanism. MethodsIn 50 patients with fetal growth restriction(group) and 50 normal term pregnant women(control group) the level of MCP-1 in maternal serum and placenta were detected by enzyme linked immunosorbent assay(ELISA) and the placental tissue sections were analyzed by pathological morphologly.ResultsIn the FGR group, the main pathological changes were different degrees of villous dysplasia, increased syncytiotrophoblast nodules and chorioamnionitis。The incidence rates were significantly higher than that in the control group［640%(32/50) vs120%(6/50),P<005］;The incidence of chorioamnionitis among the pathological change of placental tissue was 31%(10/32).In the placental pathological change group of the FGR group，the concentration of MCP-1 in the placenta was higher than the control group［placenta MCP-1:(13697±1024) vs（12976±567）ng/mL,P<005］; In the Placental pathological change group with chorioamnionitis, the concentration of MCP-1 in the placenta was significantly higher than the control group［(14976±867)vs(12976±567)ng/mL,P<005］;There was no significant difference in the concentration of serum MCP-1 between the the placental pathological change group and the control group. ［serum MCP-1 (13714±973) vs(14016±1034) ng/mL,P＞0.05］.ConclusionMCP-1 is associated with the occurrence and development of FGR,and the mechanism may be caused by excessive inflammatory reaction, which result in placental malperfusion.

参考文献/References:

［1］丰有吉，沈铿．妇产科学［M］．第2版．北京：人民卫生出版社，2010：104-107． ［2］陈乐真，陈晓端．妇产科诊断病理学［M］．北京：人民军医出版社，2010：527-530． ［3］Naruse, K. Chemokine and free fatty acid levels in insulin-resistant state of successful pregnancy:a preliminary observation［Z］, 2012: 432-575. ［4］林力华，何晓宇，李励军．MCP-1在子痫前期患者胎盘组织及血清中的表达及意义 ［J］．莆田学院学报，2011，18 （5）：26-30． ［5］BRIANA D D. Perinantal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction ［Z］, 2007: 65032. ［6］张为远，黄醒华．中华围产医学［M］．北京：人民卫生出版社，2012：550-554． ［7］WANG T, DAI H, WAN N, et al. The role for monocyte chemoattractant protein-1 in the generation and function of memory CD8+ T cells［J］. Journal of Immunology (Baltimore, Md. : 1950), 2008, 180 (5): 2886-2893. ［8］FU J, GAO Y M. Studying progress immunological mechanism of the occurrence of pregnancy-induced hypertension syndrome(PIH)［J］. Chin J Perinat Med, 2001, 4 (3): 177-179. ［9］LIN Q D. The recent research on etiology of pregnancy induced hypertension disorders ［J］. Chin J Obstet Gynecol, 2002, 18 (5): 288-330. ［10］WANG Ruo-guang, YOU Zhao-ling, CHEN Xue-dong, et al. Effect of components in Radix Astragli-Radix Salviae Mil Tiorrhizae Compound on expression of monocytic chemotactic protein mRNA on placental trophocyte of Nitrogen oxide synthesis blocking pregnant rats ［J］. Chinese Traditional and Herbal Drugs, 2005, 5 (36): 723-726.

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备注/Memo

备注/Memo:
中国疾病预防控制中心妇幼保健中心西部地区妇幼卫生能力提升项目（项目编号：2015FYQ001）
更新日期/Last Update: 2017-04-25