[1]钟卓慧.多囊卵巢综合征孕妇产科并发症及其危险因素分析[J].中国计划生育和妇产科,2017,(12):9-12.
　ZHONG Zhuo-hui.Analysis of obstetric complications and risk factors in women with polycystic ovary syndrome[J].Chinese Journal of Family Planning & Gynecotokology,2017,(12):9-12.
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多囊卵巢综合征孕妇产科并发症及其危险因素分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年12期
页码:
9-12
栏目:
论著与临床
出版日期:
2017-12-25

文章信息/Info

Title:
Analysis of obstetric complications and risk factors in women with polycystic ovary syndrome
作者:
钟卓慧
广州市妇女儿童医疗中心妇科
Author(s):
ZHONG Zhuo-hui
Department of Gynecology，Guangzhou Women and Children Medical Center，Guangzhou Guangdong 510623，P.R.China
关键词:
多囊卵巢综合征; 产科并发症; 危险因素
Keywords:
polycystic ovary syndrome;  obstetric complications;  risk factors
分类号:
R 71175
摘要:
目的探讨多囊卵巢综合征（polycystic ovary syndrome, PCOS）孕妇产科并发症发生情况，并分析其主要产科并发症的相关危险因素，为PCOS孕妇产科并发症的预防提供依据。方法选取广州市妇女儿童医疗中心妇产科2010年1月至2016年10月就诊的468例PCOS孕妇为研究组，另选298例非PCOS孕妇为对照组。分析比较两组产科并发症的发生率；选择21项相关临床指标作为研究变量，进行Logistic回归分析。结果PCOS孕妇自然流产、妊娠期高血压（pregnancy induced hypertension， PIH）与妊娠期糖尿病（gestational diabetes mellitus, GDM）的发生率明显高于非PCOS孕妇（P< 005）；年龄、孕前腰臀比及血清睾酮水平是PCOS孕妇自然流产的独立危险因素；孕前腰臀比及24周孕期增重是PCOS孕妇PIH的独立危险因素；孕前腰臀比、24周孕期增重及胰岛素抵抗指数（homeostasis model of assessment for insulin resistence index, HOMA-IR）是PCOS孕妇GDM的独立危险因素。结论PCOS孕妇产科并发症增加，主要表现在自然流产、PIH与GDM的发病率升高；影响这些产科并发症发生的独立危险因素有年龄、孕前腰臀比、24周孕期增重、血清睾酮水平及HOMA-IR，PCOS孕妇应针对这些因素积极预防。
Abstract:
ObjectiveTo investigate the occurrence of complications of polycystic ovary syndrome (PCOS) in pregnant women and to analyze the related risk factors of obstetric complications.To provide evidence for prevention of obstetric complications in pregnant women with PCOS. MethodsA total of 468 cases of pregnant women with PCOS who were treated in Guangzhou Women and Children Medical Center from January 2010 to October 2016 were selected as the study group. 298 cases of pregnant women without PCOS were selected as the control group. The incidence of complications in the two groups was analyzed and compared. 21 related clinical indexes were selected as the study variables and Logistic regression analysis was performed. ResultsThe incidence of spontaneous abortion,pregnancy induced hypertension(PIH) and gestational diabetes mellitus (GDM) in pregnant women with PCOS was significantly higher than that in pregnant women without PCOS(P<005).Age,pre-pregnancy waist to hip ratio, serum testosterone levels were independent risk factors of spontaneous abortion in pregnant women with PCOS; Pre-pregnancy waist hip ratio and 24 weeks of weight gain during pregnancy were independent risk factor of PIH; Pre-pregnancy waist hip ratio, 24 weeks of pregnancy weight gain and HOMA-IR were independent risk factors of GDM. ConclusionThe obstetric complications in patients with PCOS are increased, and mainly manifest in the increased incidence of spontaneous abortion,PIH and GDM. Independent risk factors affecting these obstetric complications include age, pre-pregnancy waist hip ratio, 24 weeks of pregnancy weight gain, serum testosterone level and HOMA-IR. Pregnant women with PCOS should be actively targeting these factors for prevention.

参考文献/References:

［1］LI Rong, ZHANG Qiufang, YANG Dongzi, et al. Prevalence of polycystic ovary syndrome in women in China: a large community-based study ［J］. Hum Reprod, 2013, 28(9): 2562-2569. ［2］Kollmann M, Klaritsch P, Martins WP, et al. Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions ［J］. Hum Reprod, 2015, 30(10): 2396-2403. ［3］李婷婷，徐静．多囊卵巢综合征综合治疗对其妊娠结局的影响 ［J］．实用妇科内分泌电子杂志，2016，3（4）：1-2． ［4］Boomsma CM, Fauser BC, Macklon NS. Pregnancy complications in women with polycystic ovary syndrome ［J］. Hum Reprod Update, 2015, 26(5): 72-84. ［5］The Rotterdam ESHER/ASRM-sponsored PCOS Consensus Workshop Group. Revsied 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome ［J］. Hum Reprod, 2004, 19(1): 41-47. ［6］Rosenfield RL. The polycystic ovary Morphology-Polycystic ovary syndrome spectrum ［J］. J Pediatr Adolesc Gynecol, 2015, 28(6): 412-419. ［7］WAN Hei-lok tiffany, Hui PW, LI Hang-wun raymond, et al. Obstetric outcomes in women with polycystic ovary syndrome and isolated polycystic ovaries undergoing in vitro fertilization: a retrospective cohort analysis ［J］. Journal of Maternal-Fetal & Neonatal Medicine, 2015, 28(4): 475-478. ［8］QIN Jun-z, PANG Li-h, LI Mu-j, et al. Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis ［J］. Reproductive Biology and Endocrinology, 2013, 11(1): 1-14. ［9］Zezza L, Ralli E, Conti E, et al. Hypertension in pregnancy: the most recent findings in pathophysiology, diagnosis and therapy ［J］. Minerva Ginecol, 2014, 66(1): 103-126. ［10］Jaskolka D, Retnakaran R, Zinman B, et al. Sex of the baby and risk of gestational diabetes mellitus in the mother: a systematic review and meta-analysis ［J］. Diabetologia, 2015, 58(11): 2469-2475.

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备注/Memo

备注/Memo:
广东省人口与计划生育委员会科研基金（项目编号：20133073）
更新日期/Last Update: 2017-12-25