[1]谢洁玲*,蔡叶萍.宫颈上皮内瘤变宫颈环形电切除术后对育龄妇女生育的影响[J].中国计划生育和妇产科,2017,(5):40-43.
　XIE Jie-ling*,CAI Ye-ping.Effects of LEEP on fertility of childbearing age women with cervical intraepithelial neoplasia[J].Chinese Journal of Family Planning & Gynecotokology,2017,(5):40-43.
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宫颈上皮内瘤变宫颈环形电切除术后对育龄妇女生育的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年5期
页码:
40-43
栏目:
论著与临床
出版日期:
2017-05-25

文章信息/Info

Title:
Effects of LEEP on fertility of childbearing age women with cervical intraepithelial neoplasia
作者:
谢洁玲*; 蔡叶萍
肇庆市端州区妇幼保健院妇产科
Author(s):
XIE Jie-ling*;  CAI Ye-ping
Department of Obstetrics and Gynecology, Maternal and Child Healthcare Hospital of Duanzhou District, Zhaoqing City, Zhaoqing Guangdong 526000, P.R. China
关键词:
宫颈上皮内瘤变;  LEEP术; 生育能力; 分娩方式; 妊娠结局
Keywords:
cervical intraepithelial neoplasia;  LEEP surgery;  fertility;  mode of delivery;  pregnancy outcomes
分类号:
R 737.33;R 730.56
摘要:
目的探讨育龄妇女宫颈上皮内瘤变(cervical intraepithelial neoplasias,CIN)行宫颈环形电切除术(loop electrosurgical excision procedure,LEEP)术后对生育能力及妊娠结局的影响。方法选取2010年6月至2012年6月在肇庆市端州区妇幼保健院因CIN行LEEP的育龄妇女118例（ CINⅠ29例，CINⅡ64例，CINⅢ25例）中于2013年6月前正常妊娠的育龄妇女107例作为观察组。选取同期在本院住院分娩的健康孕妇121例作为对照
Abstract:
ObjectiveTo explore the influence of LEEP surgery on fertility and pregnancy outcomes of women of childbearing age with cervical intraepithelial neoplasia(CIN). Methods118 women of childbearing age who had LEEP surgery in Maternal and Child Healthcare Hospital of Duanzhou District, Zhaoqing City because of CIN from June 2010 to June 2012 including 29 preoperative CIN I, 64 CIN II and 25 CIN III. 107 women among them who had normal pregnancy before June 2013 were collected as the observation group.121 healthy pregnant women who were hospitalized and delivered in our hospital over the same period were randomly selected as the control group. Delivery mode and pregnancy outcomes of the two groups were analyzed. Results① The observation group had a postoperative pregnancy rate of 9068%, while the control group had a postoperative pregnancy rate of about 93%. The difference was not statistical significant（P＞005）.② The observation group had a significantly higher cesarean section rate than the control group, （P＜005）. There was no statistical significant difference （P＞005）. ③ There was no statistical significant difference in incidence rate of abortion （P＞005）; the observation group had higher incidence rates of premature delivery and premature rupture of membrane than the control group; and newborns of the observation group had lower weight than the control group（P＜005）. ④ In the observation group, there was no statistical significant difference in abortion rate among team CIN I, CIN II and CIN III（P＞005）. Team CIN III had significantly higher postoperative premature delivery rate, incidence rate of premature rupture of membrane and incidence rate of low weight of newborns than team Ⅰ and Ⅱ（P＜005）. By comparing postoperative abortion rate, premature delivery rate, incidence rate of premature rupture of membrane, and incidence rate of low weight of newborns between CIN I and II, there was no statistical significant difference（P＞005）. ConclusionLEEP surgery with CIN patients has no effect on patients' pregnancy capacity and does not affect the mode of delivery. CIN III patients had significantly higher postoperative premature delivery rate, incidence rate of premature rupture of membrane and incidence rate of low weight of newborns than CIN I patients and CIN II patients.

参考文献/References:

［1］周萍，王沂峰.宫颈环形电切术后妊娠及分娩结局的临床分析［J］.中国计划生育和妇产科，2014，6（2）：47-49. ［2］丰有吉，沈铿．妇产科学 ［M］．北京：人民卫生出版社，2002：394-399． ［3］陈兢思，陈敦金宫颈锥切术对生育的影响 ［J］实用妇产科杂志，2009，25(7):395-396. ［4］VAN DE VIJVER A, POPPE W, VERGUTS J, et al. Pregnancy outcome after cervical conisation: a retrospective cohort study in the Leuven University Hospital ［J］. BJOG-An International Journal of Obstetrics and Gynaecology, 2010, 117(3): 268-273. ［5］ORTOFT G, HENRIKSEN T, HANSEN E, et al. After conisation of the cervix, the perinatal mortality as a result of preterm delivery increases in subsequent pregnancy ［J］. BJOG-An International Journal of Obstetrics and Gynaecology, 2010, 117(3): 258-267. ［6］HAGEN B, SKJELDESTAD F E. The outcome of pregnancy after CO2 laser conisation of the cervix ［J］. British Journal of Obstetrics and Gynaecology, 1993, 100(8): 717-720. ［7］SADLER L, SAFTLAS A, WANG Wenquan, et al. Treatment for cervical intraepithelial neoplasia and risk of preterm delivery ［J］. JAMA : the Journal of the American Medical Association, 2004, 291(17): 2100-2106. ［8］LEIMAN G, HARRISON N A, RUBIN A. Pregnancy following conization of the cervix: complications related to cone size ［J］. American Journal of Obstetrics and Gynecology, 1980, 136(1): 14-18. ［9］SUH-BURGMANN E J, WHALL-STROJWAS D, CHANG Y, et al. Risk factors for cervical stenosis after loop electrocautery excision procedure ［J］. Obstetrics and Gynecology, 2000, 96(5 Pt 1): 657-660.

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更新日期/Last Update: 2017-05-25