[1]张雯碧,徐丛剑*.子宫内膜异位症对胚胎和子宫内膜的影响[J].中国计划生育和妇产科,2017,(2):1- 3,7.
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子宫内膜异位症对胚胎和子宫内膜的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年2期
页码:
1- 3,7
栏目:
辅助生殖研究新进展专题
出版日期:
2017-02-25

文章信息/Info

作者:
张雯碧徐丛剑*
复旦大学附属妇产科医院
关键词:
子宫内膜异位胚胎内膜临床结局
分类号:
R 711.71
摘要:
子宫内膜异位症(endometriosis,EMs)与不孕症密切相关,其可从卵泡发育、排卵、运输、受精、着床、受精卵发育等各个环节影响正常妊娠,导致不孕。EMs主要通过影响卵子质量间接影响胚胎质量,从而引起种植率下降。卵子质量下降可能与EMs患者卵子发育的微环境(卵泡液)氧化应激反应相关,此外与线粒体能量代谢及DNA复制减少相关。EMs可从细胞形态、基因转录到蛋白分子调节方面的异常导致内膜容受性下降,从而影响胚胎的着床。多项荟萃分析指出合并EMs将降低体外受精的临床结局。辅助生育技术之前是否需要切除内膜样囊肿目前仍存争议,需就具体情况而定。

参考文献/References:

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更新日期/Last Update: 2017-02-25