[1]杨纨,王海燕*.多囊卵巢综合征与复发性流产[J].中国计划生育和妇产科,2017,(10):1-6.
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多囊卵巢综合征与复发性流产
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年10期
页码:
1-6
栏目:
综述
出版日期:
2017-10-25

文章信息/Info

作者:
杨纨; 王海燕*
北京大学第三医院妇产科生殖医学中心
关键词:
多囊卵巢综合征; 复发性流产; 高胰岛素血症; 肥胖; 二甲双胍
分类号:
R 714.21
摘要:
多囊卵巢综合征（polycystic ovarian syndrome，PCOS）属于内分泌紊乱性疾病，是复发性流产（recurrent spontaneous abortion，RSA）的危险因素之一。本文综述PCOS引起RSA的因素分析和治疗现状。PCOS引起RSA的因素主要是高胰岛素血症/胰岛素抵抗、高雄激素水平和肥胖，此外，高黄体生成素水平、高同型半胱氨酸血症和血栓前状态与胰岛素抵抗、高雄激素水平、肥胖三者之间相辅相成，互相促进，共同作用导致RSA的发生。在治疗方面，孕前减轻体重至少 5 %、孕前乃至整个孕期服用二甲双胍是有效降低流产的治疗方案；抗凝治疗仍存在争议，尚缺乏有效的循证医学证据；口服避孕药等降低雄激素的治疗目前暂不推荐使用。

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更新日期/Last Update: 2017-10-25