[1]刘畅,刘湘源*.非传统抗磷脂抗体在产科抗磷脂综合征诊断中的价值[J].中国计划生育和妇产科,2017,(11):14- 18,23.
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非传统抗磷脂抗体在产科抗磷脂综合征诊断中的价值
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年11期
页码:
14- 18,23
栏目:
综述
出版日期:
2017-11-25

文章信息/Info

作者:
刘畅刘湘源*
北京大学第三医院风湿免疫科
关键词:
产科抗磷脂综合征抗磷脂酰乙醇胺抗体抗磷脂酰丝氨酸依赖的抗凝血酶原抗体抗膜联蛋白抗体抗β2GPⅠ结构域1抗体IgA亚型抗磷脂抗体
分类号:
R 5932
摘要:
明确诊断的产科抗磷脂综合征(obstetric antiphospholipid antibody syndrome,OAPS)患者及抗磷脂抗体 (antiphospholopid antibodies,aPLs)相关复发性流产(recurrent spontaneous abortion,RSA)患者中传统的抗β2糖蛋白Ⅰ抗体(anti-β2 glycoprotein, aβ2GPⅠ)、抗心磷脂抗体(anticardiolipin,aCL)和狼疮抗凝物(lupus anticoagulant,LA)抗体阳性率及滴度均较低,三大常规aPLs均阴性的符合抗磷脂综合征(antiphospholipid antibody syndrome,APS)临床诊断标准的患者,按APS治疗后的妊娠结局多得到明显改善,而这部分患者中有68 %可以检测到至少一种的“非传统”抗磷脂抗体,包括抗磷脂酰乙醇胺抗体(anti-phosphatidylethanolamine antibodies,aPE)、抗凝血酶原抗体(antiprothrombin,aPT)、抗磷脂酰丝氨酸依赖的抗凝血酶原抗体(antiphosphatidylserine/prothrombin,aPS/PT)、抗膜联蛋白抗体、抗β2GPⅠ结构域1抗体、IgA型抗体谱等,而这些抗体与产科并发症有着显著的相关性,是提高OAPS诊断率的明日之星。

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更新日期/Last Update: 2017-11-25