[1]陈芳,杜娟,韩磊*.免疫-炎症反应在子痫前期病理过程中的作用新进展[J].中国计划生育和妇产科,2017,(8):13-17.
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免疫-炎症反应在子痫前期病理过程中的作用新进展
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年8期
页码:
13-17
栏目:
综述
出版日期:
2017-08-25

文章信息/Info

作者:
陈芳1;  杜娟1; 韩磊2*
1. 400042重庆，解放军第三军医大学大坪医院野战外科研究所病理科；2. 100101北京，解放军第306医
关键词:
子痫前期; 炎症反应; 病理过程; 免疫系统; 调节性T细胞
分类号:
R 714.24+5
摘要:
子痫前期（preeclampsia，PE）是导致围产期母儿死亡的重要疾病，患者多表现出肾功能减退、胎儿生长受限、全身炎症反应状态和自身抗体的产生。既往的研究假说认为：滋养细胞侵袭受限导致胎盘缺血、缺氧，并引起母胎界面的免疫失衡，促炎性的CD 4+T细胞增多，而调节性T细胞（T regulatory cells，Tregs）减少，进而引发以氧化应激、促炎性细胞因子（如内皮素）、活性氧和自身抗体（如血管紧张素II的1型受体的竞争性抗体）生成为主要特征的慢性炎症，这些因素共同作用，导致孕期血压升高。关于调节性免疫细胞对于PE病理过程作用的最新研究提示，通过输入Tregs细胞或输注白细胞介素-10的方法增加Tregs数量可以降低胎盘缺氧的妊娠大鼠模型的血压，为PE发病机制中炎症反应的病理过程奠定了充分的理论基础。

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备注/Memo

备注/Memo:
国家自然科学基金（项目编号：81401224）
更新日期/Last Update: 2017-08-25