[1]陈欢欢,洪莉*.间苯三酚对IVF/ICSI-ET治疗出现子宫内膜负向蠕动波的不孕患者的临床效果分析[J].中国计划生育和妇产科,2017,(8):65-67,76.
　CHEN Huan-huan,HONG Li*.Clinical effect of phloroglucinol on infertile patients with endometrial negative peristaltic wave undergoing IVF / ICSI-ET[J].Chinese Journal of Family Planning & Gynecotokology,2017,(8):65-67,76.
点击复制

间苯三酚对IVF/ICSI-ET治疗出现子宫内膜负向蠕动波的不孕患者的临床效果分析
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年8期
页码:
65-67,76
栏目:
论著与临床
出版日期:
2017-08-25

文章信息/Info

Title:
Clinical effect of phloroglucinol on infertile patients with endometrial negative peristaltic wave undergoing IVF / ICSI-ET
作者:
陈欢欢; 洪莉*
武汉大学人民医院妇产科
Author(s):
CHEN Huan-huan;  HONG Li*
Department of Obstetrics and Gynaecology, Renmin Hospital of Wuhan University, Wuhan Hubei 614000, P. R. China
关键词:
IVF/ICSI-ET; 间苯三酚; 子宫内膜负向蠕动波
Keywords:
IVF/ICSI-ET;  phloroglucinol;  endometrial negative peristaltic wave
分类号:
R 711.6
摘要:
目的探讨体外受精/胞浆内单精子注射-胚胎移植（in vitro fertilization/ intracytoplasmic sperm injection- embryo transfer，IVF/ICSI-ET）治疗不孕过程中使用间苯三酚对患者的临床效果。方法选取2014年10月至2015年3月在武汉大学人民医院进行IVF/ICSI-ET治疗出现子宫内膜负向蠕动波的不孕患者66例作为研究对象，按照随机数字表法将全部患者分为观察组（32例，使用间苯三酚注射液静脉滴注）和对照组（34例，未用间苯三酚）。对两组患者负向蠕动波的变化趋势进行观测记录，采用费雪确切概率法比较平滑肌解痉药物间苯三酚对IVF/ICSI-ET患者子宫内膜负向蠕动波水平、临床妊娠率、异位妊娠率、流产率以及妊娠结局的影响。结果观察组子宫内膜负向蠕动波消失率和增加率（8750 %，0 %）与对照组（3824 %，2941 %）相比，差异有统计学意义(χ2=17003、11092，P＜005)。观察组7 min内出现负向波频数低于对照组，差异有统计学意义(t=9528，P＜005)。观察组临床妊娠率（6250 %）高于对照组（2634 %），差异有统计学意义(χ2=8687，P＜005)。观察组和对照组的流产率（625 % vs 588 %）和异位妊娠率（313 % vs 1563 %）比较差异无统计学意义(P＞005)。结论间苯三酚应用于IVF/ICSI-ET治疗不孕患者，可以减少对子宫内膜的刺激，抑制子宫平滑肌痉挛性收缩，减少子宫内膜负向蠕动波，提高临床妊娠率。
Abstract:
ObjectiveTo investigate the clinical efficacy of phloroglucinol in the treatment of infertility in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI-ET).MethodsA total of 66 infertile women with endometrial negative peristaltic wave treated with IVF / ICSI-ET in Renmin Hospital of Wuhan University from October 2014 to March 2015 were selected as study object. They were divided into observation group (32 cases, phloroglucinol intravenous infusion) and control group (34 cases) according to the random number table method. The changes of negative peristaltic wave in the observation group and the control group were observed. The effects of phloroglucinol on the levels of negative peristaltic wave, clinical pregnancy rate, ectopic pregnancy rate, abortion rate and pregnancy outcome in IVF/ICSI-ET patients were compared by Fisher exact probability method.ResultsEndometrial negative peristaltic wave disappearance rate and increase rate(87.50%,0%) of the observation group compared with the control group (3824%, 2941%) the differences were statistically significant(χ2=17003,11092，P＜005). The frequency of negative peristaltic wave in the observation group was lower than that in the control group, the difference was statistically significant(t=9528，P＜005). The clinical pregnancy rate in the observation group(6250%) was significantly higher than that in the control group(2634%), the difference was statistically significant(χ2=8687，P＜005). There were no significant differences between the observation group and the control group on abortion rate (625% vs 588%) and ectopic pregnancy rate (313% vs 1563%)(P＞ 005).ConclusionThe use of phloroglucinol in IVF / ICSI-ET treatment of infertility can reduce the stimulation of the endometrium, inhibit uterine smooth muscle spasm contraction, reduce endometrial negative creep wave and improve clinical pregnancy rate.

参考文献/References:

［1］黄晓卉, 张昌军, 王华, 等超促排卵妇女子宫内膜蠕动的临床意义 ［J］实用医学杂志, 2006, 22 （2）: 148-149. ［2］徐步芳,冯云,王枫钊,等．胚胎移植日子宫内膜运动波对冻融胚胎移植周期妊娠结局的预测价值 ［J］．中华临床医师杂志，2011,5 （14）：4033-4037． ［3］Leal Almeida M, Saucedo de la Llata E, Batiza Resendiz V,et al. Endometrial thickness. prognostic factor in assisted reproduction? ［J］. Ginecol obstet Mex, 2004, 72(3): 116-119. ［4］叶雅萍，欧奇志．间苯三酚在胚胎移植中的应用价值 ［J］．广西医科大学学报，2015，32 （5）：783-785． ［5］Simon C, Moreno C, Remohi J,et al. Cytokines and embryo implantation ［J］. Reprod Immunol, 1998, 39 (1-2): 117-131. ［6］曹仁康．影响体外受精-胚胎移植中胚胎质量的因素 ［J］．现代养生B，2014（6）：40． ［7］Wanabe T, huma S, amamoto Y, et al. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germ line ［J］. Dev cell, 2011, 20(3): 364-375. ［8］BULLETTI C, DE ZIEGLER D. Uterine contractility and embryo implantation ［J］. Current Opinion in Obstetrics & Gynecology, 2005, 17(3): 265-276. ［9］李健和，易利丹，彭六保，等．间苯三酚的药理作用与临床应用 ［J］．中国新药与临床杂志，2011，30 （7）：494-499． ［10］高凤霞，马金红．间苯三酚联合利多卡因用于宫腔镜术前准备的效果评价 ［J］．实用医学杂志，2013，29 （18）：3101-3102． ［11］孙妍．间苯三酚在产程活跃期疗效的观察 ［J］．吉林医学，2013，34（15）：2920-2921． ［12］刘洪梅，谢翠英．间苯三酚治疗原发性痛经疗效观察 ［J］．吉林医学，2011，32（32）：6768-6769． ［13］刘文枝，刘惠娜．间苯三酚治疗妊娠剧吐的临床观察 ［J］．中国现代药物应用，2012，6 （3）：88-89． ［14］Xu A, Li Y, Zhu L, et al. Inhibition of endometrial fund cervical wave by phloroglucinol and the outcome of in vitro fertilization ［J］. Reprod Biol, 2013, 13 (1): 88-91.

相似文献/References:

[1]王涛,陈红.间苯三酚联合催产素在足月孕引产中应用的临床观察[J].中国计划生育和妇产科,2011,(06):0.
　WANG Tao,CHEN Hong.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(8):0.
[2]尹璐,张瑜,刘大庆,等.应用间苯三酚治疗产程活跃期宫颈水肿的临床观察[J].中国计划生育和妇产科,2014,(09):0.
　YIN Lu,ZHANG Yu,LIU Da-qing,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(8):0.

更新日期/Last Update: 2017-08-25