[1]徐珩*,陈力.子痫前期患者妊娠晚期心脏形态和功能变化及其与血清脑钠肽水平的相关性[J].中国计划生育和妇产科,2018,(8):50-53.
　XU Heng*,CHEN Li.Changes of cardiac morphology and function in preeclampsia patients in late pregnancy and their correlation with serum brain natriuretic peptide levels[J].Chinese Journal of Family Planning & Gynecotokology,2018,(8):50-53.
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子痫前期患者妊娠晚期心脏形态和功能变化及其与血清脑钠肽水平的相关性
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年8期
页码:
50-53
栏目:
论著与临床
出版日期:
2018-08-25

文章信息/Info

Title:
Changes of cardiac morphology and function in preeclampsia patients in late pregnancy and their correlation with serum brain natriuretic peptide levels
作者:
徐珩*; 陈力
深圳市妇幼保健院妇产科
Author(s):
XU Heng*;  CHEN Li
Department of Gynecology and Obstetrics,Maternal and Child Health Care Hospital of Shenzhen, Shenzhen Guangdong 518000,P.R.China
关键词:
子痫前期; 心脏形态; 心脏功能; 脑钠肽
Keywords:
preeclampsia; the heart form; cardiac function; brain natriuretic peptide
分类号:
R 714.24
摘要:
目的探讨子痫前期患者心脏形态和功能变化及其与血清脑钠肽（brain natriuretic peptide，BNP）水平的相关性。方法选择深圳市妇幼保健院产科2014年1月至2016年10月收治的妊娠期高血压疾病患者165例（研究组），并根据患者病情严重程度分为3个亚组，其中妊娠期高血压组（A组）45例、轻度子痫前期组（B组）64例和重度子痫前期组（C组）56例，选择同期正常妊娠晚期孕妇50例作为对照组。比较各组舒张末期室间隔厚度（interventricular septum thickness，IVST）、左室后壁厚度（left ventricular posterior wall thickness，LVP-WT）、左室内径（left ventricular diameter，LVD）、左房收缩末期内径（left atrial end-systolic diameter， LAESd）、左室射血分数（left ventricular ejection fraction，LVEF）、心输出量（cardiac output，CO）、心脏指数（cardiac index，CI）、舒张早期最大流速（E峰）、舒张晚期最大流速（A峰）、E/A比值、血清BNP水平，探讨血清BNP水平与各指标的相关性。结果研究组IVST、LVP-WT、LVD、LAESd均显著高于对照组（P＜005），上述各项指标在A、B、C组呈升高趋势（P＜005）；左心室收缩功能、舒张功能各项指标在研究组和对照组之间、A组和C组之间差异均有统计学意义（P＜005），C组LVEF、E峰、A峰、E/A值与B组差异有统计学意义（P＜005），子痫前期患者血清BNP与IVST、LVP-WT、LVD、LAESd、CO、CI、E峰、A峰均无相关性，与LVEF、E/A值均呈显著负相关（P＜005）。结论子痫前期患者心脏形态发生变化，心功能受损，尤其重度子痫前期患者上述变化更为明显，血清BNP水平可在一定程度上反映患者的心功能状态。
Abstract:
ObjectiveTo investigate the correlation between cardiac morphology and function change and serum brain natriuretic peptide(BNP) level in late pregnancy patients with preeclampsia. Methods165 patients with gestational hypetension(research group) admitted to Maternal and Child Health Care Hospital of Shenzhen from January 2014 to October 2016 were selected, according to the degree of illness as gestational hypertension were divided into gestational hypetension group(group A ,45 cases), mild preeclampsia group (group B, 64 cases) and severe preeclampsia group(group C,56 cases), and 50 pregnant women in normal late pregnancy were chosen as the control group.Interventricular septal thickness(IVST), left ventricular posterior wall thickness (LVP-WT), left interior diameter(LVD), left atrial end-systolic diameter(LAESd), left ventricular ejection fraction(LVEF) and cardiac output(CO), cardiac index(CI), E peak, A peak, E/A ratio and serum BNP level were compared between the groups, and the correlation of serum BNP level with the indexes were discussed. ResultsIVST, LVP - WT, LVD, LAESd of the research group were significantly higher than those of the control group(P<005), the above indexes showed a trend of increase in group A, B and C(P<005);The indexes of left ventricular systolic function, diastolic function between the research group and the control group, and between group A and the group C had statistically significant differences(P<005), the differences of LVEF,E peak,A peak,E/A value of the group C and group B were statistically significant(P<005), serum BNP in patients with preeclampsia had no correlation with IVST,LVP-WT,LVD,LAESd,CO,CI,E peak, A peak, and showed significant negative correlation with LVEF and E/A value(P<005). ConclusionThe heart form of patients with preeclampsia morphology changes,heart function is impaired, especially in severe preeclampsia patients,the changes are more obvious.Serum BNP levels can reflect the patient's cardiac function to some extent.

参考文献/References:

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更新日期/Last Update: 2018-08-25