[1]陈爱平*,蔡长争,陈丽花,等.促性腺激素释放激素激动剂对子宫内膜异位症 腹腔镜术后患者症状缓解率及复发率的影响[J].中国计划生育和妇产科,2017,(12):53-56.
　CHEN Ai-ping*,CAI Chang-zheng,CHEN Li-hua,et al.Effect of GnRH-a on symptom remission rate and recurrence rate in patients with endometriosis after laparoscopic surgery[J].Chinese Journal of Family Planning & Gynecotokology,2017,(12):53-56.
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促性腺激素释放激素激动剂对子宫内膜异位症 腹腔镜术后患者症状缓解率及复发率的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年12期
页码:
53-56
栏目:
论著与临床
出版日期:
2017-12-25

文章信息/Info

Title:
Effect of GnRH-a on symptom remission rate and recurrence rate in patients with endometriosis after laparoscopic surgery
作者:
陈爱平1*; 蔡长争2; 陈丽花1; 李优3
1. 518110广东深圳，龙华区中心医院妇科；2. 518110广东深圳，龙华区中心医院检验科；3. 518000广东深圳，宝安区沙井人民医院产科
Author(s):
CHEN Ai-ping1*; CAI Chang-zheng2; CHEN Li-hua1; LI You3
1.Department of Gynecology; 2.Department of Laboratory, Central Hospital of Longhua District of Shenzhen City,Shenzhen Guangdong 518110; 3. Department of Obstetrics and Gynecology, Shajing People's Hospital of Baoan District of Shenzhen City, Shenzhen Gua
关键词:
GnRH-a; 子宫内膜异位症; 腹腔镜手术; 氧化应激状态; 临床疗效
Keywords:
GnRH-a; endometriosis;  laparoscopic surgery;  oxidative stress status;  clinical effect
分类号:
R 71171
摘要:
目的研究并探讨促性腺激素释放激素激动剂 (gonadotropin releasing hormone- agonist，GnRH-a) 对子宫内膜异位症患者行腹腔镜手术后的氧化应激状态、症状缓解率以及复发率的影响。方法选取2015年10月至2016年12月于深圳市龙华区中心医院行腹腔镜手术并接受术后随访的100例子宫内膜异位症患者为研究对象，根据随机数字表法将其分为观察组 (50例) 和对照组 (50例)。术后，观察组患者皮下注射GnRH-a进行治疗，对照组患者口服孕三烯酮进行治疗。检测并对比两组患者在治疗前及连续治疗3个月后的活性氧 (reactive oxygen species，ROS) 、丙二醛 (malondialdehyde，MDA) 、超氧化物歧化酶 (superoxide dismutase，SOD) 以及血浆谷胱甘肽过氧化物酶 (glutathione peroxidase，GSH-Px)的水平，比较两组患者随访1年的临床症状缓解率和复发率。结果两组患者治疗前的血清ROS、MDA、SOD以及GSH-Px浓度比较，差异无统计学意义(P>005)；治疗3个月后两组的ROS和MDA浓度降低，SOD以及GSH-Px浓度明显升高，观察组各项指标改善情况优于对照组，差异有统计学意义 (P<005)。随访1年，观察组的临床症状缓解率以及复发率情况优于对照组，但差异无统计学意义(P>005)。结论GnRH-a能够有效改善子宫内膜异位症患者行腹腔镜术后的氧化应激状态，提高患者治疗效果，降低复发率，提高生活质量，值得临床推广。
Abstract:
ObjectiveTo study and discuss effect of gonadotropin releasing hormone agonist(GnRH-a) on oxidative stress status, symptom remission rate and recurrence rate of patients with endometriosis after laparoscopic surgery. Methods100 cases of patients with endometriosis treated with laparoscopic surgery and followed-up in Central Hospital of Longhua District of Shenzhen City from October 2015 to December 2016 were selected , the patients were divided into the observation group(50 cases) and the control group (50 cases) according to the random number table. After surgery，patients of the observation group were treated with subcutaneous injection of GnRH-a, and patients of the control group were treated with oral administration of gestrinone. The levels of reactive oxygen species(ROS), malondialdehyde(MDA), superoxide dismutase(SOD) and plasma glutathione peroxidase(GSH-Px) of patients before and after 3 months’ treatment were detected and compared. At the same time, the clinical symptom remission rate and recurrence rate of patients of the two groups were recorded during the follow-up period of one year. ResultsThere were no statistical differences in serum ROS, MDA, SOD and GSH-Px concentrations before treatment between the two groups. After 3 months’ treatment, the ROS and MDA concentrations of patients of the two groups decreased, SOD and GSH-Px concentrations were significantly increased. The improvement of the observation group was better than that of the control group. The differences were statistically significant(P<005). The clinical symptom remission rate and recurrence rate of patients of the observation group were better than those of the control group one year after treatment, but the differences were not significant(P>005). ConclusionGnRH-a can effectively improve the oxidative stress of patients with endometriosis after laparoscopic surgery, improve the treatment effect and reduce the recurrence rate, improve the quality of life, thus it is worthy of clinical promotion.

参考文献/References:

［1］DUNSELMAN G A, VERMEULEN N, BECKER C, et al. ESHRE guideline: management of women with endometriosis ［J］. Human Reproduction (Oxford, England), 2014, 29(3): 400-412. ［2］叶明珠，郭红燕，韩劲松，等．子宫内膜异位症患者痛经与病灶分期及特征的相关性 ［J］．中华医学杂志，2015，95（9）：685-688． ［3］郑兴宗．腹腔镜手术分别联合GnRH-a与孕三烯酮治疗子宫内膜异位症的效果比较 ［J］．实用药物与临床，2014，17（3）：378-381． ［4］陈楚红．GnRH-a联合腹腔镜手术在子宫内膜异位症中的综合应用价值研究 ［J］．临床和实验医学杂志，2013，12（22）：1806-1809． ［5］HUANG J, CUIGE Y U. Clinical efficacy of GnRH-a in treatment of endometriosis after laparoscopic surgery ［J］. Journal of Modern Oncology, 2012, 21(5): 125-129. ［6］施鹏．腹腔镜联合GnRH-α治疗子宫内膜异位症的疗效观察 ［J］．中国妇幼保健，2014，29（1）：149-151． ［7］中华人民共和国卫生部. 中药新药临床研究指导原则 ［S］. 北京：中国医药科技出版社, 1993:267-269. ［8］LESSEY B A, LEBOVIC D I, TAYLOR R N. Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects ［J］. Seminars in Reproductive Medicine, 2013, 31(2): 109-124. ［9］刘平，马成斌，劳国颖．卵巢子宫内膜异位囊肿患者盆腔病灶分布与疼痛、不孕的相关性 ［J］．中国妇幼保健，2014，29（1）：25-28． ［10］郭蕊萌，孙惠淼．氧化应激对子宫内膜异位症患者在位内膜容受性的影响 ［J］．现代妇产科进展，2016，25（12）：907-910． ［11］胡兴焕，邹伟．腹腔镜手术联合温肾活血中药治疗子宫内膜异位症疗效及对血清 Th 1/Th 2、氧化应激水平的影响 ［J］．现代中西医结合杂志，2016，25（29）：3208-3211． ［12］赵健，张玲爱．促性腺激素释放激素激动剂联合反向添加法治疗子宫内膜异位症的临床研究 ［J］．中国性科学，2012,21（9）：32-34． ［13］王成刚．GnRH-a联合反加疗法治疗子宫内膜异位症的疗效及安全性分析 ［J］．实用药物与临床，2012，15（11）：728-730． ［14］彭华，张燕，朱翠婷，等．孕三烯酮对子宫内膜异位症腹腔镜术后氧化应激状态的影响 ［J］．蚌埠医学院学报，2012，37（6）：663-665．

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更新日期/Last Update: 2017-12-25