[1]李静*,李美林,孙国宏,等.抗血管药物治疗Ⅲ/Ⅳ期和复发性卵巢癌疗效的荟萃分析[J].中国计划生育和妇产科,2018,(6):42-47.
 LI Jing*,LI Mei-lin,SUN Guo-hong,et al.A meta-analysis of the efficacy of anti-angiogenic agents in thetreatment of stage III / IV and recurrent ovarian cancer[J].Chinese Journal of Family Planning & Gynecotokology,2018,(6):42-47.
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抗血管药物治疗Ⅲ/Ⅳ期和复发性卵巢癌疗效的荟萃分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年6期
页码:
42-47
栏目:
论著与临床
出版日期:
2018-06-25

文章信息/Info

Title:
A meta-analysis of the efficacy of anti-angiogenic agents in the treatment of stage III / IV and recurrent ovarian cancer
作者:
李静1*李美林2孙国宏2李科珍3
1. 434000湖北荆州,荆州市第三人民医院妇产科;2.436000湖北鄂州,武汉大学人民医院附属鄂州市中心医院妇产科; 3.430030湖北武汉,华中科技大学同济医学院附属同济医院妇产科
Author(s):
LI Jing1*LI Mei-lin2SUN Guo-hong2LI Ke-zhen3
1.Department of Obstetrics and Gynecology, Jingzhou Third People's Hospital,Jingzhou Hubei 434000,P.R.China;2. Department of Obstetrics and Gynecology,Ezhou Central Hospital Affiliated of Wuhan University People's Hospital, Ezhou Hubei 436000;3. Departmen
关键词:
血管生成抑制剂Ⅲ/Ⅳ期复发性卵巢癌荟萃分析
Keywords:
anti-angiogenic drugs stage III/IV recurrent ovarian cancer meta-analysis
分类号:
R 737.31
摘要:
目的评估血管生成抑制剂治疗Ⅲ/Ⅳ期和复发性卵巢癌的价值。方法检索PubMed、Cochrane Library、Embase、Web of Science和CNKI数据库,检索血管生成抑制剂治疗Ⅲ/Ⅳ期和复发性卵巢癌的随机对照试验,根据纳入与排除标准筛选符合要求的研究,并使用Stata 140软件进行统计学处理,合并分析纳入研究的效应量,探索血管生成抑制剂治疗Ⅲ/Ⅳ期和复发性卵巢癌的疗效。结果血管生成抑制剂能够显著延长卵巢癌患者的无进展生存期(progression-free survival, PFS)和总生存期(overall survival, OS)[PFS=071 (95 % CI: 063~079,P<005),OS=087 (95 % CI: 074~086,P<005)]。结论血管生成抑制剂可以改善卵巢癌患者的PFS和OS,尤其是对复发性卵巢癌患者的改善更具有推广意义。
Abstract:
bjectiveTo evaluate the value of anti-angiogenic agents in the treatment of stage III/IV and recurrent ovarian cancer. MethodsPubMed, Cochrane Library, Embase, Web of Science and CNKI databases were searched for randomized controlled trials of anti-angiogenic therapy about stage III/IV and recurrent ovarian cancer, screening studies were performed according to inclusion and exclusion criteria, and Stata 14.0 software were used, and the pooled effect of the studies was analyzed in the study to explore the efficacy of anti-angiogenic drugs in the treatment of stage III/IV and recurrent ovarian cancer. ResultsAnti-angiogenic agents significantly affected progression-free survival (PFS) and overall survival (OS) in patients with ovarian cancer, PFS = 071 (95% CI: 063~079) (P<005), OS=087 (95% CI: 074~086) (P<005). ConclusionAnti-angiogenic agents can improve PFS and OS in ovarian cancer patients, especially in patients with recurrent ovarian cancer.

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备注/Memo

备注/Memo:
湖北省卫生计生青年人才项目(项目编号:WJ2015Q004 )
更新日期/Last Update: 2018-06-25