[1]关立军*,赵慧霞,郑波,等.他莫昔芬联合小剂量睾酮治疗特发性少弱精子症的 随机对照研究[J].中国计划生育和妇产科,2018,(1):67-69.
 GUAN Li-jun*,ZHAO Hui-xia,ZHEN Bo,et al.A randomized controlled trial of tamoxifen combined with low dose testosterone in the treatment of idiopathic oligoasthenospermia[J].Chinese Journal of Family Planning & Gynecotokology,2018,(1):67-69.
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他莫昔芬联合小剂量睾酮治疗特发性少弱精子症的 随机对照研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年1期
页码:
67-69
栏目:
论著与临床
出版日期:
2018-01-25

文章信息/Info

Title:
A randomized controlled trial of tamoxifen combined with low dose testosterone in the treatment of idiopathic oligoasthenospermia
作者:
关立军*赵慧霞郑波戴芳芳赵晓丹周均霞胡一珍
邢台不孕不育专科医院生殖中心
Author(s):
GUAN Li-jun*ZHAO Hui-xiaZHEN BoDAI Fang-fangZHAO Xiao-danZHOU Jun-xiaHU Yi-zhen
Reproductive Center,XingTai Infertility Specialist Hospital,Xingtai Hebei 054000,P.R.China
关键词:
特发性少弱精子症他莫昔芬十一酸睾酮
Keywords:
oligoasthenospermiatamoxifentestosterone undecanoate
分类号:
R 6982
摘要:
目的评估他莫昔芬联合小剂量睾酮对特发性少弱精子症的治疗效果,并与单纯应用他莫昔芬的治疗效果进行比较。方法采用前瞻性随机对照研究,对2016年6月至2017年3月到邢台不孕不育专科医院就诊的特发性少弱精子症患者77例,采用分层随机分组的方法分为研究组和对照组,对用药前和用药3个月后精液分析中的精子浓度、前向运动精子百分率进行观察分析。 结果研究组治疗前后精子浓度、前向运动精子百分率比较,差异均有统计学意义(P<005);对照组治疗前后精子浓度差异有统计学意义(P<005);两组治疗后,精子浓度比较差异有统计学意义(P<005)。 结论他莫昔芬联合小剂量睾酮治疗特发性少弱精子症,有助于改善精子浓度,效果优于单一使用他莫昔芬。
Abstract:
ObjectiveTo evaluate the efficacy of tamoxifen combined with low-dose testosterone in the treatment of idiopathic oligoasthenospermia,and to compare the efficacy with tamoxifen alone. MethodsA prospective randomized controlled trial was conducted on 77 patients with idiopathic oligoasthenospermia who were treated in Xingtai Infertility Specialist Hospital from June 2006 to March 2017. They were randomly divided into two groups: the study group and the control group.The sperm concentration and the percentage of forward spermatozoa in semen analysis were observed and analyzed before and 3 months after treatment. ResultsThere were significant differences in sperm concentration and forward motile sperm before and after treatment in the study group(P<005);The differences of sperm concentration before and after treatment in the control group was statistically significant(P<005);There were significant differences in sperm concentration between the study group and the control group(P<005).ConclusionTamoxifen combined with low-dose testosterone in the treatment of oligoasthenospermia can improve sperm concentration and is superior to tamoxifen alone.

参考文献/References:

[1]Jungwirth A,Giwercman A,Tournaye H,et al.European Association of Urology guidelines on male infertility:the 2012 update [J].Eur Urol,2012,62(2):324-332. [2]Jung JH.Seo JT.Empirical medical therapy in idiopathic male infertility:promise or panacea?[J].Cbn Exp Reprod Med,2014,41(3):108-114. [3]谷诩群,陈振文等译.世界卫生组织人类精液检查与处理实验室手册 [M].第5版.北京:人民卫生出版社,2011:168-169. [4]李维娜,朱文兵,唐章明,等.16 835例中国不育男性的精液质量分析 [J].中南大学学报(医学版),2014,39(2):157-160. [5]杨立,申吉泓,刘孝东.少精症的药物治疗进展 [J].现代泌尿外科杂志,2007,12(6):418-420. [6]MOTRICH RD, PONCE AA, RIVERO VE. Effect of tamoxifen treatment on the semen quality and fertility of the male rat [J].Fertil Steri1,2007,88(2):452-461. [7]CHUA M-e, Escusa KG, Luna S, et al. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta-analysis [J]. Andrology, 2013, 1(5): 749-757. [8]何学酉,金哲.雄激素在男科疾病中的应用及安全性研究进展[J].中华医学杂志,2012,92(42):3020-3022. [9]徐文丹,代晓南.睾丸雄激素合成的调节机制及其研究进展[J].国际生殖健康/计划生育杂志,2014,33(6):428-433. [10]DA Adamopoulos, A Pappa, E Billa, et al. Effectiveness of combined tamoxifem citrate and testosterone undecanoate treatmemt in men with idopathic oligozoospermia [J]. Fertility & Sterlity, 2003,80(4):914-920. [11] 宋博,蔡志明.他莫昔芬-十一酸睾酮联合应用治疗严重少弱精子症、分泌性无精子症 [J].现代泌尿外科杂志,2011,16(5):426-428. [12] 鄢卫红,解迪,谢守珍.促性腺激素、小剂量睾酮、他莫昔芬联合应用治疗少精子症的临床疗效 [J].华南国防医学杂志,2015,29(5):393-395.

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更新日期/Last Update: 2018-01-25