[1]马迪,马文超,唐芳兰,等.共刺激分子B 7-H 4在宫颈癌组织中的表达 及其临床意义[J].中国计划生育和妇产科,2018,(4):45-48,52.
　MA Di,MA Wen-chao,TANG Fang-lan,et al.Expression and clinical significance of costimulatory molecule B7-H4 in cervical cancer[J].Chinese Journal of Family Planning & Gynecotokology,2018,(4):45-48,52.
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共刺激分子B 7-H 4在宫颈癌组织中的表达 及其临床意义
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年4期
页码:
45-48,52
栏目:
论著与临床
出版日期:
2018-04-25

文章信息/Info

Title:
Expression and clinical significance of costimulatory molecule B7-H4 in cervical cancer
作者:
马迪1 ; 马文超2; 唐芳兰1; 王艳1*
1. 150081黑龙江哈尔滨，哈尔滨医科大学附属第一医院妇产科；2. 150001黑龙江哈尔滨，哈尔滨医科大学附属第四医院急诊外科
Author(s):
MA Di1 ; MA Wen-chao2; TANG Fang-lan1; WANG Yan1*
1. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Harbin Medical University，Haerbin Heilongjiang 150081；2. Department of Emergency Surgery, the Fourth Affiliated Hospital of Harbin Medical University，Harbin Heilongjiang 150001，P
关键词:
B 7-H 4; 宫颈癌; T细胞免疫; 共刺激分子; 免疫组织化学
Keywords:
B7-H4;  cervical cancer;  T cells immune;  costimulatory molecule;  immunohistochemistry
分类号:
R 711.74
摘要:
目的探讨宫颈癌组织中B 7-H 4的表达水平及临床意义。方法选取哈尔滨医科大学附属第一医院2010～2012年因子宫肌瘤行子宫全切的正常宫颈组织30例，宫颈活检及LEEP刀治疗的宫颈上皮内瘤变组织30例及宫颈癌患者的宫颈癌组织40例，采用PV-二步法免疫组织化学方法检测新型共刺激分子B 7-H 4在各组中的表达情况。结果B 7-H 4在宫颈癌组织中较宫颈上皮内瘤变组织中和正常宫颈组织中表达的阳性率高，差异有统计学意义（P＜005）；在宫颈上皮内瘤变组织中与正常宫颈组织中表达阳性率比较，差异无统计学意义（P＞005）。B 7-H 4的阳性表达率随着宫颈癌患者病理分级的升高，淋巴结转移，呈增高趋势，但与患者年龄无关。结论B 7-H 4参与了宫颈癌的发生发展，有望成为宫颈癌新的诊断及治疗指标。
Abstract:
ObjectiveTo investigate the expression of B7-H4 in cervical cancer and its clinical significance. MethodsA total of 30 cases of normal cervical tissue with hysterectomy, 30 cases of cervical intraepithelial neoplasia treated by cervical biopsy and LEEP kn

参考文献/References:

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更新日期/Last Update: 2018-04-25