[1]刘玮,徐亮,张炜,等.双胎妊娠子痫前期的高危因素分析[J].中国计划生育和妇产科,2018,(6):55-59.
　LIU Wei,XU Liang,ZHANG Wei,et al.Analysis of high risk factors of preeclampsia in twin pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2018,(6):55-59.
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双胎妊娠子痫前期的高危因素分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年6期
页码:
55-59
栏目:
论著与临床
出版日期:
2018-06-25

文章信息/Info

Title:
Analysis of high risk factors of preeclampsia in twin pregnancy
作者:
刘玮1; 徐亮1; 张炜2; 张丽君1*
1. 200030上海，上海交通大学医学院附属国际和平妇幼保健院产科；2. 200080上海，上海市第一人民医院产科
Author(s):
LIU Wei1; XU Liang1; ZHANG Wei2; ZHANG Li-jun1*
1．Department of Obstetrics,Shanghai Jiaotong University School of Medicine Affiliated International Peace Maternity & Child Health Hospital, Shanghai 200030；2 Department of Obstetrics,The Shanghai First People's Hospital, Shanghai 200080, P.R.China
关键词:
双胎妊娠; 子痫前期; 危险因素
Keywords:
twin pregnancy;  pre eclampsia;  risk factors
分类号:
R 714.24
摘要:
目的探讨双胎妊娠发生子痫前期的高危因素。方法选取2015~2016年在上海交通大学医学院附属国际和平妇幼保健院住院分娩的54例子痫前期双胎孕妇为研究组，将108例同期无妊娠期高血压疾病的双胎孕妇作为对照组，比较两组的一般情况和妊娠结局，分析双胎孕妇发生子痫前期的危险因素。结果研究组孕前体质量指数（body mass index，BMI）、孕期体重增长均大于对照组（P＜005）；妊娠晚期D-二聚体高于对照组（P＜005），妊娠晚期纤维蛋白原低于对照组（P＜005）；体外受精（in vitro fertilization，IVF）双胎孕妇子痫前期的发生率较非IVF孕妇高（P＜005）；研究组贫血及早产的发生率高于对照组（P＜005）；孕前BMI高、孕期体重增长多、孕中晚期贫血、D-二聚体高可增加双胎孕妇子痫前期的发生风险（P＜005），妊娠晚期纤维蛋白原高可降低双胎孕妇子痫前期的发生风险（P＜005）。结论孕前BMI高、孕期体重增长多、孕中晚期贫血、D-二聚体高是双胎孕妇子痫前期发生的独立危险因素，妊娠晚期纤维蛋白原高是双胎孕妇子痫前期发生的保护因素。
Abstract:
ObjectiveTo investigate the risk factors of preeclampsia in twin pregnancy. Methods54 cases of preeclampsia twin pregnant women were selected as the study group from 2015～2016 in Shanghai Jiaotong University School of Medicine Affiliated International Peace Maternity & Child Health Hospital, the same period 108 cases of twin pregnant women without gestational hypertension disease were selectd as control group. T test and χ2 test were used to compare general conditions and pregnancy outcomes of two groups,multivariate Logistic regression analysis were used on risk factors of preeclampsia in twin pregnancy.ResultsCompared with control group, BMI before pregnancy,weight gain during pregnancy, and D-D dimer in study group were higher （P＜005）and late pregnancy fibrinogen level is lower（P＜005）.Higher BMI，higher pregnancy weight gain,anemia in late pregnancy and higher D-D dimer can increase the risk of preeclampsia（P＜005）.Higher late pregnancy fibrinogen can reduce the risk of preeclampsia（P＜005）. ConclusionHigher BMI, anemia, higher weight gain during pregnancy and higher D-D dimer are the risk factors of preeclampsia. In late pregnancy,higher fibrinogen is a protective factor of preeclampsia.

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更新日期/Last Update: 2018-06-25