[1]张玉苓.可溶性细胞间黏附分子-1与肿瘤坏死因子-α及阴道分泌物异常对妊娠结局的影响[J].中国计划生育和妇产科,2018,(8):46-49.
　ZHANG Yu-ling.Influence of sICAM-1, TNF-α and vaginal discharge on pregnancy outcome[J].Chinese Journal of Family Planning & Gynecotokology,2018,(8):46-49.
点击复制

可溶性细胞间黏附分子-1与肿瘤坏死因子-α及阴道分泌物异常对妊娠结局的影响
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年8期
页码:
46-49
栏目:
论著与临床
出版日期:
2018-08-25

文章信息/Info

Title:
Influence of sICAM-1, TNF-α and vaginal discharge on pregnancy outcome
作者:
张玉苓
郑州大学第二附属医院妇产科
Author(s):
ZHANG Yu-ling
Department of Obstetrics and Gynecology， the Second Affiliated Hospital of Zhengzhou University，Zhengzhou Henan 450014，P.R.China
关键词:
可溶性细胞间黏附分子-1; 肿瘤坏死因子-α; 阴道分泌物; 妊娠结局
Keywords:
sICAM-1;  TNF-α;  vaginal secretions;  pregnancy outcomes
分类号:
R 714.259
摘要:
目的探讨可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1，sICAM-1)与肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)及阴道分泌物异常对妊娠结局的影响。方法选择2016年4月至2017年4月在郑州大学第二附属医院产科分娩的150例早产产妇设为观察组，同期150例足月产妇为对照组。比较两组产妇血清白细胞(white blood cell，WBC)计数、C反应蛋白(C-reactive protain，CRP)、sICAM-1、TNF-α、阴道分泌物及胎盘病检结果及其与妊娠结局的关系。结果观察组血清WBC、CRP、sICAM-1、TNF-α水平均显著高于对照组，阴道分泌物致病菌检测阳性率和绒毛膜羊膜炎检出率均显著高于对照组，宫颈/阴道撕裂、产后出血、新生儿窒息、产褥期感染发生率均显著高于对照组，差异均有统计学意义(P＜005)；观察组阴道分泌物病原菌检查阳性者血清WBC、CRP、sICAM-1、TNF-α水平均显著高于阴道分泌物病原菌检查阴性者，差异有统计学意义(P＜005)；观察组绒毛膜羊膜炎者血清WBC、CRP、sICAM-1、TNF-α水平均显著高于胎盘病检结果正常者，差异有统计学意义(P＜005)。结论血清sICAM-1、TNF-α和阴道分泌物异常均为引发早产和导致产妇不良预后事件的危险因素，可作为预测感染性早产和绒毛膜羊膜炎的参考指标。
Abstract:
ObjectiveTo explore the influence of sICAM-1, TNF-α and vaginal discharge on pregnancy outcome. MethodsFrom April 2016 to April 2017, 150 premature women born in the Second Affiliated Hospital of Zhengzhou University were selected as the observation group. 150 full-term mothers in the same period were the control group.The result of serum WBC, CRP, sICAM-1, TNF-α, vaginal discharge and placenta check were observed，and these indexes’relationship with pregnancy outcomes were analyzed. ResultsThe level of serum WBC, CRP, sICAM-1, TNF-α of observation group were significantly higher than those of control group，positive rate of pathogenic bacteria detected in vaginal secretions and chorioamnionitis of observation group were higher than those of control group，the occurrence rate of cervical / vaginal tearing, postpartum hemorrhage, neonatal asphyxia, obstetric infection of observation group were higher than those of control group(P＜005).In the observation group, the level of serum WBC, CRP, sICAM-1, TNF-α of women with pathogenic bacteria detected positive in vaginal secretions were higher than vaginal secretion tested negative group, women with chorioamnionitis were higher than without chorioamnionitis, the differences were statistically significant(P＜005). Conclusion Serum sICAM-1, TNF-α, and abnormal vaginal secretions are all risk factors for preterm birth and leading to adverse outcomes in women,which can be used as reference index of predicting infectious preterm labor and chorioamnionitis.

参考文献/References:

［1］Passini R, Cecatti JG, Lajos GJ, et al. Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth［J］. PLoS One, 2014, 9(10): e109069. ［2］Baldwin EA, Walther-Antonio M, Maclean AM, et al. Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery ［J］. Peer J, 2015, 3(3): e1398. ［3］张媛，崔金晖，韩振艳，等早产胎膜早破并发胎盘病理炎症改变与新生儿预后的相关性研究 ［J］中国实用医药，2014，9（12）：48-50 ［4］Nakubulwa S, Kaye DK, Bwanga F, et al. Genital infections and risk of premature rupture of membranes in Mulago Hospital, Uganda: a case control study［J］. BMC Res Notes, 2015, 8(8): 573. ［5］Ozderya A, Aydin K, Temizkan S, et al. High circulating levels of sICAM-1 and sVCAM-1 in the patients with Hashimoto's thyroiditis ［J］. Endocr Res, 2017, 42(2): 110-116. ［6］靳钰，申彩霞，刘晓宁IL-6、TNF-α、MMP-8与胎膜早破早产及宫内感染的关系 ［J］中国优生优育，2013，19（3）：169-172 ［7］朱桃花，王芬，康莉，等孕产妇血清中MMP-3、TNF-α、IL-10的表达与早产和早产胎膜早破的关系 ［J］中国妇产科临床杂志，2012，13（3）：183-186 ［8］李馨，江元，范琦慧早产胎膜早破患者阴道分泌物培养结果分析 ［J］浙江预防医学，2014，26（1）：92-94 ［9］李坚雄，张文慧胎儿纤维连接蛋白、可溶性细胞间黏附分子-1及宫颈结构变化对早产预测的价值 ［J］中国当代医药，2014，21（11）：21-23 ［10］朱琰琴，江美艳早产孕妇血清中sICAM-1水平与胎膜早破的关系 ［J］中国现代医生，2012，50（14）：112-113 ［11］蔡坚，李玉洁，陈汉青，等母体血清可溶性细胞间黏附分子-1与早产关系的探讨 ［J］中华临床医师杂志（电子版），2014，8（12）：2284-2288 ［12］De Pablo R, Monserrat J, Reyes E, et al. Circulating sICAM-1 and sE-Selectin as biomarker of infection and prognosis in patients with systemic inflammatory response syndrome ［J］. Eur J Intern Med, 2013, 24(2): 132-138. ［13］Cantarini L, Pucino V, Vitale A, et al. Circulating intercellular adhesion molecule 1 (sICAM-1）in tumour necrosis factor receptor-associated periodic syndrome (TRAPS)［J］. Clin Exp Rheumatol, 2017, 35 Suppl 104(2): 13-14. ［14］叶祖峰IL-10、TIMP-1、TNF-α在胎膜早破早产孕妇血清、羊水中的含量及意义 ［J］中国现代医学杂志，2013，23（11）：98-100 ［15］陈年芳，钟建芳，蓝华春，等宫颈阴道分泌物及胎盘组织中纤维连接蛋白含量检测及其与早产相关分子表达量的相关性［J］海南医学院学报，2016，22（14）：1560-1563 ［16］吴玲，孟海英，梁心玲，等阴道分泌物胎儿纤维连接蛋白与宫颈长度联合预测早产的多中心前瞻性研究 ［J］中国医药导报，2013，10（9）：62-64

相似文献/References:

[1]陈倩,段成城,傅晓冬,等.血清T辅助细胞比率与妊娠期高血压疾病的关系和意义[J].中国计划生育和妇产科,2010,(03):0.
　CHEN Qian,DUAN Cheng-cheng,FU Xiao-dong..[J].Chinese Journal of Family Planning & Gynecotokology,2010,(8):0.
[2]苏士利,董白桦,赵真,等.米非司酮对引产胎儿细胞因子分泌、肝细胞增殖及肝功能影响的研究[J].中国计划生育和妇产科,2011,(02):0.
　SU Shi-li,DONG Bai-hua,ZHAO Zhen,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(8):0.

更新日期/Last Update: 2018-08-25