[1]毛萌,朱兰*.组织工程技术在盆底重建手术中应用的最新进展[J].中国计划生育和妇产科,2018,(11):19-22.
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组织工程技术在盆底重建手术中应用的最新进展
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年11期
页码:
19-22
栏目:
综述
出版日期:
2018-11-25

文章信息/Info

作者:
毛萌朱兰*
中国医学科学院北京协和医院妇产科
关键词:
盆腔脏器脱垂组织工程技术间充质干细胞支架
分类号:
R 711.2
摘要:
目的盆腔脏器脱垂发病率高,已成为一种严重影响女性生活质量的非致命性妇科疾病。阴道植入聚丙烯网片是目前临床上常用的盆底重建方法,此法虽可较好地恢复解剖结构、降低复发率,但容易导致网片侵蚀、暴露,疼痛等术后并发症。因此,迫切需要开发一些不良反应更少的生物材料。近年来,组织工程学的快速发展为治疗盆腔脏器脱垂提供了新思路。其中,间充质干细胞是组织工程技术中极具应用前景的细胞来源,而何种材料才是盆底重建手术中最为适合的细胞支架,目前学术界尚未达成一致意见。因此,为了更好地了解不同组织工程材料在盆底重建治疗中的优缺点,本文就近年来组织工程学中支架材料研究的最新进展进行综述。

参考文献/References:

[1]Giarenis I, Robinson D. Prevention and management of pelvic organ prolapse [J]. F1000 Prime Rep, 2014,6 (6):77. [2]JIA X, Glazener C, Mowatt G, et al. Efficacy and safety of using Mesh or grafts in surgery For anterior and/or posterior vaginal wall prolapse:systematic review and meta-analysis [J]. BJOG, 2008, 115 (11): 1350-1361. [3]Ruiz-Zapata AM, Kerkhof MH, Zandieh-Doulabi B, et al. Functional characteristics of vaginal fibroblastic cells from premenopausal women with pelvic organ prolapse [J]. Mol Hum Reprod, 2014, 20 (11): 1135-1143. [4]Roman S, Mangera A, Osman NI, et al. Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse-which cell source? [J]. Neurourol Urodyn, 2014, 33 (5): 531-537. [5]Ho MH, Heydarkhan S, Vernet D, et al. Stimulating vaginal repair in rats through skeletal Muscle-Derived stem cells seeded on small intestinal submucosal scaffolds [J]. Obstet Gynecol, 2009, 114 (2): 300-309. [6]Chen B, Dave B. Challenges and future prospects for tissue engineering in female pelvic medicine and reconstructive surgery [J]. Curr Urol Rep, 2014, 15 (8): 425. [7]Hsiao ST, Asgari A, Lokmic Z, et al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue [J]. Stem Cells Dev, 2012, 21 (12): 2189-2203. [8]Dissaranan C, Cruz MA, Kiedrowski MJ, et al. Rat mesenchymal stem cell secretome promotes elastogenesis and facilitates recovery from simulated childbirth injury [J]. Cell Transplant, 2014, 23 (11): 1395-1406. [9]Boennelycke M, Gras S, Lose G. Tissue engineering as a potential alternative or adjunct to surgical Reconstruction in treating pelvic organ prolapse [J]. Int Urogynecol J, 2013, 24 (5): 741-747. [10]LI Yan-an, LIU Fang-fang, ZHANG Zhi-qiang, et al. Bone marrow mesenchymal stem cells could acquire the phenotypes of epithelial cells and accelerate vaginal Reconstruction combined with small intestinal submucosa [J]. Cell Biol Int, 2015, 39 (11): 1225-1233. [11]Iyyanki TS, Dunne LW, ZHANG Qi-xu, et al. Adipose-Derived Stem-Cell-Seeded Non-Cross-Linked porcine acellular dermal matrix increases cellular infiltration, vascular infiltration, and mechanical strength of ventral hernia repairs [J]. Tissue Eng Part A, 2015, 21 (3/4): 475-485. [12]Klinger A, Kawata M, Villalobos M, et al. Living scaffolds: surgical repair using scaffolds seeded with human adipose-derived stem cells [J]. Hernia, 2016, 20 (1): 161-170. [13]WU Q, DAI M, XU P, et al. In vivo effects of human adipose-derived stem cells reseeding on acellular bovine pericardium in nude mice [J]. Exp Biol Med (Maywood), 2016, 241 (1): 31-39. [14]Huang CC, Liu CY, Huang CY, et al. Carbodimide cross-linked and biodegradation-controllable small intestinal submucosa sheets [J]. Biomed Mater Eng, 2014, 24 (6): 1959-1967. [15]Ochoa I, Pea E, Andreu EJ, et al. Mechanical properties of cross-linked collagen meshes after human adipose derived stromal cells seeding [J]. J Biomed Mater Res A, 2011, 96 (2): 341-348. [16]Spelzini F, Manodoro S, Frigerio MA, et al. Stem cell augmented mesh materials: an in vitro and in vivo study [J]. Int Urogynecol J, 2015, 26 (5): 675-683. [17]Konar S, Guha R, Kundu B, et al. Silk fibroin hydrogel as physical barrier for prevention of post hernia adhesion [J]. Hernia, 2017, 21 (1): 125-137. [18]LI Qi, WANG Jianliu, LIU Haifeng, et al. Tissue-engineered mesh for pelvic floor Reconstruction fabricated from silk fibroin scaffold with adipose-derived mesenchymal stem cells [J]. Cell Tissue Res, 2013, 354 (2): 471-480. [19]Marei NH, El-Sherbiny IM, Lotfy AA, et al. Mesenchymal stem cells growth and proliferation enhancement using PLA vs PCL based nanofibrous scaffolds [J]. Int J Biol Macromol, 2016, 93 (A): 9-19. [20]Lee JJ, Yu HS, Hong SJ, et al. Nanofibrous membrane of collagen-polycaprolactone for cell growth and tissue regeneration [J]. J Mater Sci Mater Med, 2009, 20 (9): 1927-1935. [21]Lee JH, Nam J, Kim HJ, et al. Comparison of three different methods for effective introduction of platelet-rich plasma on PLGA woven mesh [J]. Biomedical Materials, 2015, 10 (2): 025002. [22]GAO Yu-e, LIU Li-jia, Blatnik JA, et al. Methodology of fibroblast and mesenchymal stem cell coating of surgical meshes: A pilot analysis [J]. J Biomed Mater Res B Appl Biomater, 2014, 102 (4): 797-805. [23]Dolce CJ, Stefanidis D, Keller JE, et al. Pushing the envelope in biomaterial research:initial results of prosthetic coating with stem cells in a rat model [J]. Surg Endosc, 2010, 24 (11): 2687-2693. [24]Mohajeri S, Hosseinkhani H, Ebrahimi NG, et al. Proliferation and differentiation of mesenchymal stem cell on collagen sponge reinforced with polypropylene/polyethylene terephthalate blend fibers [J]. Tissue Eng Part A, 2010, 16 (12): 3821-3830. [25]GE Liang-peng, LI Qing-tao, JIANG Jun-zi, et al. Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic Reconstruction [J]. Int J Nanomedicine, 2015, 10 (4): 3193-3201. [26]Ulrich D, Edwards SL, SU Kai, et al. Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair [J]. Tissue Eng Part A, 2014, 20 (3/4): 785-798. [27]Edwards SL, Ulrich D, White JF, et al. Temporal changes in the biomechanical properties of endometrial mesenchymal stem cell seeded scaffolds in a rat model [J]. Acta Biomater, 2015, 63 (13):286-294. [28]Blazquez R, Miguel Sanchez-Margallo F, Alvarez V, et al. Surgical meshes coated with mesenchymal stem cells provide an anti-inflammatory environment by a M2 macrophage polarization [J]. Acta Biomater, 2016, 31 (2): 221-230. [29]Udpa N, Iyer SR, Rajoria R, et al. Effects of chitosan coatings on polypropylene mesh for implantation in a rat abdominal wall model [J]. Tissue Eng Part A, 2013, 19 (23/24): 2713-2723. [30]ZHANG Dan-dan, LIN Zhi-yuan (william), CHENG Ruo-yu, et al. Reinforcement of transvaginal repair using polypropylene mesh functionalized with basic fibroblast growth factor [J]. Colloids Surf B Biointerfaces, 2016, 142 (6): 10-19.

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备注/Memo

备注/Memo:
国家自然科学基金面上项目(项目编号:81571421);中国科学院战略性科技先导专项项目(课题编号:XDA16010102)
更新日期/Last Update: 2018-11-25