[1]吴楠,卢永平,刘昆,等.非综合征型唇腭裂发病危险因素的病例对照研究[J].中国计划生育和妇产科,2018,(8):33-36.
　WU Nan,LU Yong-ping,LIU Kun,et al.A case-control study on the risk factors of non-syndromic cleft lip and palate[J].Chinese Journal of Family Planning & Gynecotokology,2018,(8):33-36.
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非综合征型唇腭裂发病危险因素的病例对照研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年8期
页码:
33-36
栏目:
论著与临床
出版日期:
2018-08-25

文章信息/Info

Title:
A case-control study on the risk factors of non-syndromic cleft lip and palate
作者:
吴楠1; 卢永平2; 刘昆3; 李增健1; 刘强1; 卢利1*
1. 110002辽宁沈阳，中国医科大学附属口腔医院口腔颌面外科；2. 110031辽宁沈阳，辽宁省计划生育科学研究院优生遗传科；3. 250001山东济南，济南市口腔医院口腔颌面外科
Author(s):
WU Nan1; LU Yong-ping2; LIU Kun3; LI Zeng-jian1; LIU Qiang1; LU Li1*
1.Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of China Medical University，Shenyang Liaoning 110002；2. Liaoning of Family Planning Science Academy，Shenyang Liaoning 110031；3. Jinan City Stomatological Hospital，Jinan Sha
关键词:
非综合征型唇腭裂; 危险因素; 病例对照研究
Keywords:
non-syndromic cleft lip with or without palate;  risk factors;  case-control study
分类号:
R 7155
摘要:
目的根据对非综合征型唇腭裂患者的分析，探寻有关的环境危险因素。方法对2011年1月至2014年1月中国医科大学附属口腔医院口腔颌面外科唇腭裂治疗组的206例非综合征型唇腭裂患儿和辽宁省计划生育科学研究院319名健康儿童（对照组）进行问卷调查，统计两组儿童及其父母信息，内容涉及畸形的类型、父母文化程度及可能的危险因素等。结果两组父母学历比较差异有统计学意义（χ2母=64415，χ2父=114181，P均＜0001）；家族遗传史、主/被动吸烟和饮酒等不良生活习惯、孕早期患病和用药等4项因素与唇腭裂患病具有显著相关性（P<005）；补充叶酸作为保护性因素也与唇腭裂患病具有显著相关性（P<005）。结论家族遗传史、主/被动吸烟和饮酒等不良生活习惯、孕早期患病和用药等因素与唇腭裂的发生密切相关，孕妇孕早期应尽量避免与这些危险因素的接触，按时补充叶酸以减少子女唇腭裂的发生。
Abstract:
ObjectiveBased on the analysis of patients with non-syndromic cleft lip and palate （NSCL/P）, explore the relevant environmental risk factors. Methods206 patients from January 2011 to January 2014 in the Department of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital of China Medical University, and 319 healthy children (control group) from Liaoning Research Institute of Family Planning were questionnaire surveyed, children and their parents information, the content involved in the type of deformity, parental education and possible risk factors were analyzed. ResultsThere was significant difference between two groups in parental educational background（χ2mother=64415，χ2father=114.181，P＜0001）.The study showed that family history, master or passive smoking, sick in early pregnancy and early pregnancy medication had a significant correlation with the disease(P<005). Folic acid supplementation was a prevalence protective factor of NSCL/P with a significant correlation (P<005). ConclusionAmong the risk factors, family history, drinking and active/passive smoking, sickness and medication in early pregnancy have close relationship with occurrence of NSCL/P. Therefore, pregnant women in early pregnancy should avoid contacting with these risk factors and take sufficient folic acid.

参考文献/References:

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更新日期/Last Update: 2018-08-25