[1]刘吉.可控释地诺前列酮栓与米索前列醇应用于足月妊娠产妇引产效果的分析[J].中国计划生育和妇产科,2018,(9):61-64.
　LIU Ji.Analysis of the effect of controlled release of dinoprostone suppository and misoprostol on labor induction in full-term pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2018,(9):61-64.
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可控释地诺前列酮栓与米索前列醇应用于足月妊娠产妇引产效果的分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年9期
页码:
61-64
栏目:
论著与临床
出版日期:
2018-09-25

文章信息/Info

Title:
Analysis of the effect of controlled release of dinoprostone suppository and misoprostol on labor induction in full-term pregnancy
作者:
刘吉
无锡市第五人民医院妇产科
Author(s):
LIU Ji
Department of Obstetrics and Gynecology,Wuxi Fifth People's Hospital， Wuxi Jiangsu 214000,P.R.China
关键词:
可控释地诺前列酮栓; 米索前列醇; 足月妊娠; 引产; 促宫颈成熟; 分娩结局
Keywords:
controlled release dexamethasone suppository; misoprostol; term pregnancy; induction of labor; promotion of cervical ripening; delivery outcome
分类号:
R 719.3+1
摘要:
目的分析可控释地诺前列酮栓与米索前列醇应用于足月妊娠产妇引产中对促宫颈成熟、分娩结局和引产效果的影响。方法回顾性分析2015年7月至2017年7月无锡市第五人民医院收治的176例足月妊娠产妇的临床资料，按照使用药物不同分为两组，每组88例。对照组采用米索前列醇引产，观察组采用可控释地诺前列酮栓引产。对比两组给药前后宫颈Bishop评分、促宫颈成熟有效率、宫缩过强过频率、中断药物使用率、临产发动时间、分娩结局和引产效果。结果观察组给药4 h、6 h、12 h后宫颈Bishop评分［（645±123）、（821±178）、（1033±141）］高于对照组［（504±148）、（598±145）、（708±203）］；观察组促宫颈成熟有效率（9886 %）高于对照组（8636 %）；观察组宫缩过强过频及中断药物使用率（114 %、0）低于对照组（1023 %、682 %）；观察组临产发动时间［（682±205）h］短于对照组［（1068±352）h］；观察组引产失败率（0）低于对照组（568 %）；观察组总产程时间［（836±278）h］、产后出血量［（19527±5562）mL］少于对照组［（1396±356）h、（22517±6544）mL］；观察组羊水粪染、新生儿窒息发生率（227 %、114 %）低于对照组（1136 %、1023 %），以上各项两组比较差异均有统计学意义（P＜005）。结论可控释地诺前列酮栓应用于足月妊娠产妇引产中效果优于米索前列醇，可有效促宫颈成熟，提高引产成功率，改善分娩结局，值得临床推广。
Abstract:
ObjectiveTo analyze the effects of controlled release of dinoprostone suppositories and misoprostol on the induction of labor, the outcome of delivery and the induction of labor in the induction of labor in full-term pregnancy. MethodsRetrospective analysis of the clinical data of 176 full-term pregnant women admitted to the Wuxi Fifth People's Hospital from July 2015 to July 2017.They were divided into two groups according to the use of drugs,with 88 cases in each group. The control group was induced by misoprostol, and the observation group was induced by controlled release of dinoprostone. Compared with the two groups before and after administration, the cervical Bishop score, the promotion of cervical ripening efficiency, the excessive frequency of uterine contractions, the discontinuation of drug use rate, the time of labor initiation, the outcome of delivery and the effect of induction of labor. ResultsCervical Bishop scores ［(645±123),(821±178),(1033±141)］ were higher in the observation group than in the control group ［(504±148),(598±145),(708±203)］ after 4 h, 6 h, and 12 h.The effective rate of cervical ripening observed in the observation group(9886 %) was higher than that in the control group(8636 %). The over-frequency of uterine contractions and the discontinuation of drug use in the observation group(114 %,0) were lower than those in the control group (1023 %,682 %). The observation group's onset time［(682±205) h］ was shorter than that of the control group ［(1068±352) h］. The failure rate of induction labor in the observation group (0) was lower than that in the control group (568 %). The total labor time［(836±278)h］ and postpartum hemorrhage volume［(19527±5562)mL］ in the observation group were lower than the control group［(1396±356)h,(22517±6544)mL］. The incidence of amniotic fluid and neonatal asphyxia in the observation group(227 %,114 %) was lower than that in the control group (1136 %,1023 %), and the differences between the two gruops were statistically significant(P<005).ConclusionThe controlled release of dinoprostone suppository is better than misoprostol in the induction of labor in full-term pregnancy. It can effectively promote cervical ripening, improve the success rate of induction of labor, and improve the outcome of delivery thus is worthy of clinical promotion.

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备注/Memo

备注/Memo:
无锡市卫生计生委妇幼健康科研计划项目（项目编号：FYKY201606）
更新日期/Last Update: 2018-09-25