[1]李莹,伍绍文,陈奕*.妊娠期高血压疾病不良妊娠结局相关分析[J].中国计划生育和妇产科,2018,(9):43-47,54.
　LI Ying,WU Shao-wen,CHEN Yi*.Correlation analysis of adverse pregnancy outcomes of hypertensive disorder complicating pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2018,(9):43-47,54.
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妊娠期高血压疾病不良妊娠结局相关分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年9期
页码:
43-47,54
栏目:
论著与临床
出版日期:
2018-09-25

文章信息/Info

Title:
Correlation analysis of adverse pregnancy outcomes of hypertensive disorder complicating pregnancy
作者:
李莹; 伍绍文; 陈奕*
首都医科大学附属北京妇产医院产科
Author(s):
LI Ying; WU Shao-wen; CHEN Yi*
Department of Obstetrics,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,P.R.China
关键词:
妊娠期高血压疾病; 子痫前期; 高危因素; 妊娠结局
Keywords:
hypertensive disorders complicating pregnancy; preeclampsia; risk factors; perinatal outcomes
分类号:
R 714.24+6
摘要:
目的分析不同程度妊娠期高血压疾病（hypertensive disorders complicating pregnancy，HDCP）患者的各种检查指标及妊娠结局。方法回顾性分析2016年首都医科大学附属北京妇产医院产检并住院分娩的137例产妇的临床资料，根据HDCP情况分为3组：正常组（正常产检并分娩）50例，妊娠期高血压组（妊娠期高血压患者）19例，子痫前期组（包括轻度子痫前期和重度子痫前期）68例。比较分析3组患者孕期血清学（血常规、凝血功能、肝肾功能及唐氏筛查）、超声学指标（子宫动脉血流）情况以及新生儿出生结局。 结果3组产妇年龄、体质量指数（body mass index,BMI）、孕产次比较，差异无统计学意义（P>005）。子痫前期组分娩孕周早于正常组和妊娠期高血压组，足月分娩率较正常组和妊娠期高血压组降低，差异均有统计学意义（P<005）。子痫前期组孕期并发症比例、低出生体重儿比例高于正常组和妊娠期高血压组，重度子痫前期患者新生儿Apgar评分0～4分的比例高于正常组，差异均有统计学意义（P<005）。3组患者孕中期血清学及超声学相关指标比较，差异无统计学意义（P>005）。子痫前期组子宫动脉搏动指数、子宫动脉切迹发生率高于正常组和妊娠期高血压组，差异有统计学意义（P<005）。 结论 HDCP发病时间与病情、妊娠结局呈正相关，超声出现子宫动脉切迹是子痫前期发病的确切危险因素。
Abstract:
ObjectiveTo analyze and compare various examination indicators and pregnancy outcomes of patients with hypertensive disorder complicating pregnancy(HDCP).MethodsRetrospective analyzed of the clinical data of 137 women who in Beijing Obstetrics and Gynecology Hospital,Capital Medical University in 2016 and divided them into three groups according to the condition of HDCP: there were 50 cases in the normal group (normal birth examination and delivery), 19 cases in the hypertensive group of pregnancy (hypertension in pregnancy), and 68 cases in the preeclampsia group (including mild pre-eclampsia and severe pre-eclampsia). The serum levels (blood routine, coagulation function, liver and kidney function and Down's screening) and ultrasound parameters (uterine arterial blood flow) and neonatal birth outcomes were compared between the three groups.ResultsThere were no significant differences in age, BMI and maternal parity between the three groups(P>005). The gestational weeks of the preeclampsia group were significantly earlier than the normal group and the gestational hypertension group, and the differences were statistically significant(P<005). The proportion of complications in the preeclampsia group was significantly higher than that in the normal group and the hypertensive group in pregnancy(P<005). The proportion of low birth weight infants in the preeclampsia group was significantly higher than that in the normal group and the hypertensive group in pregnancy. The full-term delivery rate was significantly lower than that in the normal group and the hypertensive group in pregnancy. The proportion of neonatal Apgar Scores in patients with severe pre-eclampsia of 0 to 4 points was significantly higher than the normal group, and the difference was statistically significant(P<005). There were no significant differences in serum and ultrasound related indexes between the three groups(P>005). The uterine artery pulsation index and uterine artery notch rate in the preeclampsia group were significantly higher than those in the normal group and the gestational hypertension group, and the difference was statistically significant(P<005). ConclusionThe onset time of HDCP is positively correlated with the condition and pregnancy outcome. Ultrasound uterine artery notch is the exact risk factor for preeclampsia.

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备注/Memo

备注/Memo:
北京市优秀人才项目（伍绍文，2015000021469G214；李莹，2016000021469G204）；北京市医管局“青苗”计划（QML20161401）；首都医科大学附属北京妇产医院中青年学科骨干培养专项（伍绍文，fcyy201414；李莹，fcyy201602）
更新日期/Last Update: 2018-09-25