[1]吴瑞芝 综述 史惠蓉* 审校.绝经妇女非酒精性脂肪肝病及绝经激素治疗的 研究进展[J].中国计划生育和妇产科,2018,(3):20-22,31.
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绝经妇女非酒精性脂肪肝病及绝经激素治疗的 研究进展
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年3期
页码:
20-22,31
栏目:
综述
出版日期:
2018-03-25

文章信息/Info

作者:
吴瑞芝 综述 史惠蓉* 审校
郑州大学第一附属医院妇产科
关键词:
非酒精性脂肪肝病绝经妇女绝经激素治疗
分类号:
R 575.5
摘要:
非酒精性脂肪肝病(nonalcoholic fatty liver disease, NAFLD)是指除外酒精和其他明确肝损害因素所致的,以大泡性肝细胞脂肪变性为主要特征的临床病理综合征,根据进展程度不同可分为单纯性脂肪肝病,脂肪性肝炎,脂肪性肝纤维化和肝硬化。NAFLD是发达国家引起慢性肝病最常见的原因,随着肥胖和代谢综合征在全球范围的流行,亚洲地区NAFLD发病率也在迅速增高。临床和流行病学研究表明,NAFLD在两性中发病趋势不同,绝经前女性患病率低于男性,而绝经后女性高于男性。本文综述绝经妇女NAFLD流行特点和雌激素的保肝作用,并讨论激素补充治疗是否能够对NAFLD发挥预防和治疗作用。

参考文献/References:

[1]S A K. Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease [J]. World Journal of Gastroenterology, 2010,16(18):2223-2226. [2]赵晓云,陈伟华,路永刚,等.河北省33 843机关职员非酒精性脂肪肝患病率及其危险因素 [J].中国老年学杂志,2013,33(20):5079-5081. [3]WANG Z x m-h. Prevalence of nonalcoholic fatty liver disease and its metabolic risk factors in women of different ages and body mass index [J]. Menopause (New York, N.Y.), 2015,22(6): 667-673. [4]王亚东,张英泽,赵彩彦,等.性激素在非酒精性脂肪性肝病发病机制中的作用 [J].中华肝脏病杂志,2012,20(5):398-400. [5]Ryu S,Suh BS,Chang Y,et al.Menopausal stages and non-alcoholic fatty liver disease in middle-aged women [J]. Eur J Obstet Gynecol Reprod Biol,2015,190(7):65-70. [6]Matsuo K,Gualtieri MR,Cahoon SS,et al. Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer [J]. Menopause,2016,23(2):189-196. [7]HJ Pan,HT Chang,CH Lee. Association between tamoxifen treatment and the development of different stages of nonalcoholic fatty liver disease among breast cancer patients [J]. J Formos Med Assoc,2015,115(6):411-417. [8]MF S A. Nonalcoholic fatty liver disease in women [J]. Women's Health (Hillsdale, N.J.), 2009,5(2): 191-203. [9]王莎莎,温晓玉.长时间的雌激素缺乏增加绝经后女性非酒精性脂肪性肝病发生肝纤维化的风险 [J].临床肝胆病杂志,2016,32(5):913. [10]JD Yang,MF Abdelmalek,H Pang,et al. Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis [J]. Hepatology, 2014,59(4): 1406-1414. [11]BALLESTRI S, NASCIMBENI F, BALDELLI E A, et al. NAFLD as a sexual dimorphic disease: role of gender and reproductive status in the development and progression of nonalcoholic fatty liver disease and inherent cardiovascular risk [J]. Advances in Therapy, 2017, 34(6): 1291-1326. [12]DI E t e p-s. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis [J]. Disease Models & Mechanisms, 2015,8(9): 1037-1046. [13]KAMADA Y K. Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet [J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011,301(6): G1031. [14]F Luo,M Ishigami,K Achiwa,et al.Raloxifene ameliorates liver fibrosis of nonalcoholic steatohepatitis induced by Choline-Deficient High-Fat Diet in ovariectomized mice [J]. Digestive Diseases and Sciences, 2015,60(9): 2730-2739. [15]G Bryzgalova,L Lundholm,N Portwood,et al.Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice [J]. American Journal of Physiology-Endocrinology and Metabolism, 2008,295(4): E904-E912. [16]JM P D. Effects of ovariectomy on PPAR alpha,SREBP-1c,and SCD-1 gene expression in the rat liver [J]. Menopause (New York, N.Y.), 2008,15(6): 1169-1175. [17]ZHANG Z s s-l. Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice [J]. Journal of Hepatology, 2015,63(6): 1466-1475. [18]P Kumar,RK Kale,NZ Baquer. Estradiol modulates membrane-linked ATPases, antioxidant enzymes, membrane fluidity, lipid peroxidation, and lipofuscin in aged rat liver [J]. Journal Of Aging Research,2011,2011(3):580245. [19]ITAGAKI T C. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells [J]. Gut, 2005,54(12):1782. [20]YOSHIKAWA K I. Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice [J]. Laboratory Investigation, 2010,90(8): 1169-1178. [21]FUKUI M H. 17 beta-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30 [J]. Biochemical and Biophysical Research Communications, 2011,415(2): 252-257. [22]H P C. Hormone replacement therapy in menopausal women:risk factor or protection to nonalcoholic fatty liver disease?[J]. Annals of Hepatology, 2012,11(1): 147-149. [23]FLORENTINO G S, COTRIM H P, VILAR C P, et al. Nonalcoholic fatty liver disease in menopausal women [J]. Arquivos de Gastroenterologia, 2013, 50(3): 180-185. [24]SUP J S. Effects of HRT on liver enzyme levels in women with type 2 diabetes:a randomized placebo-controlled trial [J]. Clinical Endocrinology, 2006,65(1): 40-44. [25]ROSSOUW J S. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause [J]. Journal of the American Medical Association, 2007,297(13): 1465-1477.

更新日期/Last Update: 2018-03-25