[1]陈薇,陆月梅*,王琛琛,等.血管内皮生长因子、血管生成素- 2及巨噬细胞移动抑制因子在子宫内膜异位症患者血清中的表达水平及在疾病发生发展中的意义[J].中国计划生育和妇产科,2018,(10):47-49,53.
　CHEN Wei,LU Yue-mei*,WANG Chen-chen,et al.Expression of MMIF, Ang-2 and VEGF in serum of patients with endometriosis and its significance in the development of disease[J].Chinese Journal of Family Planning & Gynecotokology,2018,(10):47-49,53.
点击复制

血管内皮生长因子、血管生成素- 2及巨噬细胞移动抑制因子在子宫内膜异位症患者血清中的表达水平及在疾病发生发展中的意义
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年10期
页码:
47-49,53
栏目:
论著与临床
出版日期:
2018-10-25

文章信息/Info

Title:
Expression of MMIF, Ang-2 and VEGF in serum of patients with endometriosis and its significance in the development of disease
作者:
陈薇; 陆月梅*; 王琛琛; 丁其培; 章杨韦
南通大学附属海安医院妇产科
Author(s):
CHEN Wei; LU Yue-mei*; WANG Chen-chen; DING Qi-pei; ZHANG Yang-wei
Department of and Gynecology Obstetrics,the Affiliated Haian Hospital of Nantong University，Nantong Jiangsu 226600,P.R.China
关键词:
血管内皮生长因子; 血管生成素- 2; 巨噬细胞移动抑制因子; 子宫内膜异位症
Keywords:
vascular endothelial growth factor;  angiopoietin-2;  macrophage migration inhibitory factor;  endometriosis
分类号:
R 711.71
摘要:
目的分析血管内皮生长因子（vascular endothelial growth factor，VEGF）、血管生成素- 2（Angiopoietin – 2，Ang-2）及巨噬细胞移动抑制因子（macrophage migration inhibitory factor，MMIF）在子宫内膜异位症患者血清中的表达水平及在疾病发生发展中的意义。方法回顾性分析2014年1月至2017年6月海安医院收治的患者临床资料， 子宫内膜异位症患者84例为A组，良性卵巢肿瘤患者78例为B组，各项检测指标均正常的体检合格者60例为对照组。检测MMIF、Ang-2、VEGF指标，比较3组VEGF、Ang-2及MMIF的表达水平，分析3者在子宫内膜异位症疾病进展中的作用。结果A组VEGF、Ang-2及MMIF的表达水平较B组、对照组均升高，且B组高于对照组（P<005）。VEGF、Ang-2及MMIF在A组按R-AFS分期为Ⅲ~Ⅳ期患者中的表达水平高于Ⅰ~Ⅱ期者；VEGF、Ang-2及MMIF在A组痛经评分为2~3分患者中的表达水平高于0~1分者（P均<005）。结论VEGF、Ang-2及MMIF可能参与子宫内膜异位症的病理生理过程，且与R-AFS分期、痛经评分存在显著关系，可为临床诊断与靶向治疗提供重要的参考依据。
Abstract:
ObjectiveTo analyze the expression levels of vascular endothelial growth factor (VEGF),Angiopoietin-2(Ang-2) and macrophage migration inhibitory factor(MMIF) in patients with endometriosis and the significance in the development of the disease. Methods84 cases of endometriosis in the Affiliated Haian Hospital of Nantong University from January 2014 to June 2017 were selected as group A, 78 cases of benign ovarian tumor with eutopic endometrium as group B, and 60 cases of physical examination qualified women as the control group. The expression levels of VEGF, Ang-2 and MMIF in the three groups were compared, and the correlation between the three factors and the progression of endometriosis was analyzed. ResultsThe expression levels of VEGF, Ang-2 and MMIF in the group A were significantly higher than those in group B and control group; the expression levels of three factors in group B were significantly higher than those in the control group, which showed that there were significant difference of expression levels among the three groups（P<005). The expression levels of VEGF, Ang-2 and MMIF in patients with stage III~IV for the American Association of Reproductive staging criteria (R-AFS) in group A were significantly higher than those in patients with stage for I~II; the expression levels of VEGF, Ang-2 and MMIF in patients with 2~3 scores for dysmenorrhea scores in group A were significantly higher than those in patients with 0~1 score (P<005). ConclusionThe VEGF, Ang-2 and MMIF may be involved in the pathophysiological process of endometriosis, and there are significant correlation between the three factors and R-AFS stages, dysmenorrhea score, which can provide important theoretical basis for clinical diagnosis and targeted therapy.

参考文献/References:

［1］GRAHAM A, FALCONE T, NOTHNICK W B. The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival ［J］. Human Reproduction, 2015, 30 (3): 642-652. ［2］谢幸，苟文丽．妇产科学 ［M］．第8版．北京：人民卫生出版社，2013：268-269． ［3］RAKHILA H, GIRARD K, LEBOEUF M, et al. Macrophage migration inhibitory factor is involved in ectopic endometrial tissue growth and Peritoneal-Endometrial tissue interaction in vivo: a plausible Link to endometriosis development ［J］. PLOS One, 2014, 9 (10): e110434. ［4］赵洁，薛素萍，曲银娥，等．HIF-1α和VEGF在子宫内膜异位症增生期内膜中的表达及意义 ［J］．中国实验诊断学，2012，16（3）：429-431． ［5］孙文秀，曲银娥，马思琪，等．白介素-17和血管内皮生长因子在子宫内膜异位症中的作用 ［J］．解剖学杂志，2015，38（4）：416-419． ［6］GIANNICE R, ERRENI M, ALLAVENA P, et al. Chemokines mRNA expression in relation to the Macrophage Migration Inhibitory Factor (MIF) mRNA and Vascular Endothelial Growth Factor (VEGF) mRNA expression in the microenvironment of endometrial cancer tissue and normal endometrium: a pilot study ［J］. Cytokine, 2013, 64 (2): 509-515. ［7］MAHDIAN S, AFLATOONIAN R, YAZDI R S, et al. Macrophage migration inhibitory factor as a potential biomarker of endometriosis ［J］. Fertility and Sterility, 2015, 103 (1): 153. ［8］王丹，李怀芳．达菲林联合腹腔镜术治疗子宫内膜异位症对VEGF,Ang-2和Tie-2水平的影响 ［J］．中国妇幼健康研究，2016，27（8）：994-997． ［9］WANG Dong, LUO Liang, CHEN Wei, et al. Significance of the vascular endothelial growth factor and the macrophage migration inhibitory factor in the progression of hepatocellular carcinoma ［J］. Oncology Reports, 2014, 31 (3): 1199-1204. ［10］王春红，魏静波，曲银娥，等．血管内皮生长因子及其受体在子宫内膜异位症中的表达和意义 ［J］．中国免疫学杂志，2013，29（6）：605-609． ［11］SUN Huan-xing, CHOO-WING R, SURESHBABU A, et al. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia- induced injury in the developing murine lung ［J］. PLOS One, 2013, 8 (4): e60560. ［12］胡倩倩，严浩，李盛，等．VEGF,RANTES,sflt-1及MCP-1在子宫内膜异位症合并代谢综合征的表达及意义 ［J］．中国妇幼健康研究，2016，27（4）：463-465． ［13］KOBAYASHI H, HIGASHIURA Y, SHIGETOMI H, et al. Pathogenesis of endometriosis:the role of initial infection and subsequent sterile inflammation ［J］. Molecular Medicine Reports, 2014, 9 (1): 9-15. ［14］JIANG Qiao-ying, WU Rui-jin. Growth mechanisms of endometriotic cells in implanted places: a review ［J］. Gynecological Endocrinology, 2012, 28 (7): 562-567. ［15］VERIT F F, YUCEL O. Endometriosis, leiomyoma and adenomyosis: the risk of gynecologic malignancy ［J］. Asian Pacific Journal of Cancer Prevention: APJCP, 2013, 14 (10): 5589-5597.

相似文献/References:

[1]胡玲,胡健蓉,徐凤仪,等.血管内皮生长因子在子宫内膜癌中的表达及其意义[J].中国计划生育和妇产科,2011,(01):0.
　HU Ling,HU Jian-rong,XU Feng-yi,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(10):0.
[2]梁寿珺,范余娟,黄尹,等.血管内皮生长因子+936TC基因多态性同子宫内膜异位症遗传易感性的Meta分析[J].中国计划生育和妇产科,2012,(04):0.
　LIANG Shou-jun,FAN Yu-juan*,HUANG Yin,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2012,(10):0.
[3]袁媛,张宇娇,傅晓冬,等.干扰素α-2b对早孕合并细菌性阴道病绒毛血管超微结构及血管内皮生长因子表达的影响[J].中国计划生育和妇产科,2014,(01):0.
　YUAN Yuan,ZHANG Yu-jiao,FU Xiao-dong,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(10):0.
[4]冯永冬,黎克全.凝血功能及血管内皮生长因子与子宫肌瘤引起月经过多的相关性研究[J].中国计划生育和妇产科,2014,(03):0.
[5]王本昀,刘洁.血管内皮生长因子、妊娠相关蛋白A联合检测在鉴别诊断先兆流产及异位妊娠中的价值[J].中国计划生育和妇产科,2015,(10):0.
　WANG Ben-yun,LIU Jie,[J].Chinese Journal of Family Planning & Gynecotokology,2015,(10):0.
[6]王军玲,罗淑红.血管内皮生长因子及其可溶性受体在子宫内膜异位症患者血清、腹腔液中的表达及意义[J].中国计划生育和妇产科,2016,(04):0.
　WANG Jun-ling,LUO Shu-hong,[J].Chinese Journal of Family Planning & Gynecotokology,2016,(10):0.
[7]王丹,胡萍,陈小燕,等.子宫内膜癌中胎盘特异性蛋白和胎盘生长因子的表达及其临床意义[J].中国计划生育和妇产科,2019,(5):74.
　WANG Dan,HU Ping,CHEN Xiao-yan,et al.Expression and clinical significance of PLAC1 and PLGF in endometrial carcinoma[J].Chinese Journal of Family Planning & Gynecotokology,2019,(10):74.
[8]于婉莹,曾彬,郭婉茹,等.培养液生长因子评估与胚胎质量及发育潜能的 关系研究[J].中国计划生育和妇产科,2019,(7):37.
　YU Wan-ying,ZENG bin,Guo Wan-ru,et al.Evaluation of embryo quality and potential development by culture medium growth factors[J].Chinese Journal of Family Planning & Gynecotokology,2019,(10):37.

更新日期/Last Update: 2018-10-25