参考文献/References:
［1］CONLON M A, BIRD A R. The impact of diet and lifestyle on gut microbiota and human health ［J］. Nutrients, 2015, 7 (1): 17-44.
［2］GAJER P, BROTMAN R M, BAI Guo-yun, et al. Temporal dynamics of the human vaginal microbiota ［J］. Science Translational Medicine, 2012, 4 (132): 132-152.
［3］RAVEL J, GAJER P, ABDO Z, et al. Vaginal microbiome of reproductive-age women ［J］. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (1): 4680-4687.
［4］RAVEL J, BROTMAN R M, GAJER P, et al. Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis ［J］. Microbiome, 2013, 1 (1): 29.
［5］PETROVA M I, LIEVENS E, MALIK S, et al. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health ［J］. Frontiers in Physiology, 2015, 6 (3): 81.
［6］STOYANCHEVA G, MARZOTTO M, DELLAGLIO F A. Bacteriocin production and gene sequencing analysis from vaginal Lactobacillus strains ［J］. Archives of Microbiology, 2014, 196 (9): 645-653.
［7］ANAHTAR M N, BYME E H, DOHERTY K E, et al. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract ［J］. Immunity, 2015, 42 (5): 965-976.
［8］AIYAR A, QUAYLE A J, BUCKNER L R, et al. Influence of the tryptophan-indole-IFN gamma axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections ［J］. Frontiers in Cellular and Infection Microbiology, 2014, 4 (7): 72.
［9］USLUOGULLARI B, GUMUS I, GUNDUZ E, et al. The role of human Dectin-1 Y238X gene polymorphism in recurrent vulvovaginal candidiasis infections ［J］. Molecular Biology Reports, 2014, 41 (10): 6763-6768.
［10］BROTMAN R M, RAVEL J, BAVOIL P M, et al. Microbiome, sex hormones, and immune responses in the reproductive tract: challenges for vaccine development against sexually transmitted infections ［J］. Vaccine, 2014, 32 (14): 1543-1552.
［11］ROSE I W, MCGOWIN C L, SPAGNUOLO R A, et al. Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer cultures ［J］. PLOS One, 2012, 7 (3): e32728.
［12］YARBROUGH V L, WINKLE S, HERBST-KRALOVETZ M M. Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications ［J］. Human Reproduction Update, 2015, 21 (3): 353-377.
［13］DOERFLINGER S Y, THROOP A L, HERBST-KRALOVETZ M M. Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner ［J］. Journal of Infectious Diseases, 2014, 209 (12): 1989-1999.
［14］NASIOUDIS D, BEGHINI J, BONGIOVANNI A M, et al. Amylase in vaginal fluid: association with conditions favorable to dominance of lactobacillus ［J］. Reproductive Sciences, 2015, 22 (11): 1393-1398.
［15］MONCLA B J, CHAPPELL C, DEBO B M, et al. The effects of hormones and vaginal microflora on the content of MUC1, MUC4, MUC5AC and MUC7 in the cervicovaginal fluid (CVF) ［J］. AIDS Research and Human Retroviruses, 2014, 30 (1): A29.
［16］PANDIT H, GOPAL S, SONAWANI A, et al. Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production ［J］. PLOS One, 2014, 9 (7): e102395.
［17］DONDERS G G. Definition and classification of abnormal vaginal flora ［J］. Best Practice & Research in Clinical Obstetrics & Gynaecology, 2007, 21 (3): 355-373.
［18］MITCHELL C, MARRAZZO J. Bacterial vaginosis and the cervicovaginal immune response［J］. American Journal of Reproductive Immunology, 2014, 71 (6, SI): 555-563.
［19］WITKIN S S, LINHARES I M, GIRALDO P. Bacterial flora of the female genital tract: function and immune regulation ［J］. Best Practice & Research in Clinical Obstetrics & Gynaecology, 2007, 21(3): 347-354.
［20］PYLES R B, VINCENT K L, BAUM M M, et al. Cultivated vaginal microbiomes alter HIV-1 infection and antiretroviral efficacy in colonized epithelial multilayer cultures ［J］. PLOS One, 2014, 9 (3): e93419.
［21］MIRMONSEF P, ZARIFFARD M R, GILBERT D A, et al. Short-chain fatty acids induce pro-inflammatory cytokine production alone and in combination with Toll-Like receptor ligands ［J］. American Journal of Reproductive Immunology, 2012, 67 (5): 391-400.
［22］O'HANLON D E, THOMAS R M, RICHARD A Cone.Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota ［J］. PLOS One, 2013, 8 (11): e80074.
［23］GONG Z, LUNA Y, YU P, et al. Lactobacilli inactivate chlamydia trachomatis through lactic acid but not H2O2 ［J］. PLOS One, 2014, 9 (9): e107758-e107758.
［24］ISAACS C E, XU Wei-min. Theaflavin-3,3 `-Digallate and lactic acid combinations reduce herpes simplex virus infectivity ［J］. Antimicrobial Agents and Chemotherapy, 2013, 57 (8): 3806-3814.
［25］HEARPS A, GUGASYAN R, SRBINOVSKI D, et al. Lactic acid, a vaginal microbiota metabolite, elicits an anti-inflammatory response from vaginal and cervical epithelial cells ［J］. AIDS Research and Human Retroviruses, 2014, 30 (1): A238-A239.
［26］BEGHINI J, LINHARES I M, GIRALDO P C, et al. Differential expression of lactic acid isomers, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-8 in vaginal fluid from women with vaginal disorders ［J］. BJOG-An International Journal of Obstetrics and Gynaecology, 2015, 122 (12): 1580-1585.
［27］WITKIN SS1, MENDES-SOARES H, LINHARES IM, et al. Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections ［J］. MBio, 2013, 4 (4)：e00460-13.
［28］ARNOLD K, BIRSE K, MCKINNON L, et al. Mucosal integrity factors are perturbed during bacterial vaginosis: a proteomic analysis ［J］. AIDS Research and Human Retroviruses, 2014, 30 (1): A30.
［29］NUNN K, WANG Ying-ying, HARIT D, et al. Influence of vaginal microbiota on the diffusional barrier properties of cervicovaginal mucus ［J］. AIDS Research and Human Retroviruses, 2014, 30 (1): A234.
［30］ROMERO R, HASSAN S S, GAJER P, et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term ［J］. Microbiome, 2014, 2 (1): 18.
［31］GRAVETT M G, WITKIN S S, HALUSKA G J, et al. An experimental model for intraamniotic infection and preterm labor in rhesus monkeys ［J］. American Journal of Obstetrics and Gynecology, 1994, 171 (6): 1660-1667.
［32］HAFNER L M. Pathogenesis of fallopian tube damage caused by Chlamydia trachomatis infections ［J］. Contraception, 2015, 92 (2): 108-115.
［33］TYUTYUNNIK V L, KAN N-e, LOMOVA N A, et al. Role of innate immunity in pregnant patients with vulvovaginal infections in the development of intrauterine infection in the newborn ［J］. Bulletin of Experimental Biology and Medicine, 2014, 158 (1): 74-76.