[1]刘佳,蔡小凤*.髓源抑制性细胞和调节性T淋巴细胞在母胎免疫耐受中的作用探讨[J].中国计划生育和妇产科,2018,(10):71-73.
　LIU Jia,CAI Xiao-feng*.The role of myeloid suppressor cells and regulatory T lymphocytes in maternal fetal immune tolerance[J].Chinese Journal of Family Planning & Gynecotokology,2018,(10):71-73.
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髓源抑制性细胞和调节性T淋巴细胞在母胎免疫耐受中的作用探讨
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年10期
页码:
71-73
栏目:
论著与临床
出版日期:
2018-10-25

文章信息/Info

Title:
The role of myeloid suppressor cells and regulatory T lymphocytes in maternal fetal immune tolerance
作者:
刘佳; 蔡小凤*
鄂东医疗集团黄石市中医医院妇产科
Author(s):
LIU Jia; CAI Xiao-feng*
Department of Gynecology and Obstetrics,East Hubei Medical Group Huangshi Chinese Medicine Hospital,Huangshi Hubei 435000,P.R.China
关键词:
髓源抑制性细胞; 调节性T淋巴细胞; 妊娠; 原因不明复发性流产
Keywords:
MDSCs;  Treg;  pregnancy ;  unexplained recurrent spontaneous abortion(URSA)
分类号:
R 714.259
摘要:
目的探讨髓源抑制性细胞（myeloid-derived suppressor cells，MDSCs）和调节性T淋巴细胞（regulatory T-Cell，Treg）在维持母胎免疫耐受中的作用。方法选取2016年8月至2017年4月黄石市中医医院妇产科孕检正常的孕妇（孕12周）60例以及原因不明复发性流产(unexplained recurrent spontaneous abortion，URSA)孕妇（孕12周）60例，另选体检的非妊娠育龄期健康女性40例作为对照。流式细胞仪检测MDSCs和Treg。结果MDSCs在非孕妇、正常孕妇及URSA孕妇外周血中的比例分别为（102±023）%、（372±064）%和（268±051）%，Treg在非孕妇、正常孕妇及URSA孕妇外周血中的比例分别为（314±057）%、（643±114）%和（502±084）%，其中URSA孕妇和正常孕妇都高于非孕妇，URSA孕妇低于正常孕妇，差异均有统计学意义（P＜005）。正常孕妇外周血MDSCs比例在孕前、孕12、24、36周分别为：（107±024）%、（372±064）%、（542±104）%和（786±132）%，各孕周间比较差异有统计学意义（P＜005）。正常孕妇外周血Treg比例在孕前、孕12、24、36周分别为：（311±053）%、（643±114）%、（912±146）%和（1045±182）%，各孕周间比较差异有统计学意义（P＜005）。MDSCs和Treg在外周血的比例呈显著正相关（P＜005）。结论妊娠期MDSCs高表达刺激了Treg细胞分化成熟，从而维持了母胎免疫耐受，MDSCs减低是URSA的一个可能原因，有可能作为临床治疗的靶点。
Abstract:
ObjectiveTo explore the role of myeloid derived suppressor cells（MDSCs）and regulatory T lymphocytes（Treg）in maternal and fetal immune tolerance. Methods60 pregnant women (12 weeks pregnant) with unexplained recurrent spontaneous abortion (URSA) and 60 normal pregnant women (pregnant 12 weeks) were selected from August 2016 to April 2017 in the Department of Gynecology and Obstetrics of Huangshi Chinese Medicine Hospital. 40 cases of non pregnant women in the same period were selected as controls. MDSCs and Treg expression was detected using flow cytometry. ResultsThe percentages of MDSCs in the peripheral blood in non pregnant women, normal pregnant women (12 weeks gestation) and URSA pregnant women (pregnant 12 weeks) were （102±023）%, （372±064）%, and （268±051）% respectively. The percentages of Treg in the peripheral blood of pregnant women, normal pregnant women and URSA pregnant women were (314±057) %, (643±114) % and (502±084) % respectively. URSA pregnant women and normal pregnant women were higher than non-pregnant women, URSA pregnant women were lower than normal pregnant women, the differences were statistically significant (P<005). The proportion of MDSCs in peripheral blood of normal pregnant women before pregnancy and at 12, 24,36 gestational weeks were (107±024) %, (372±064) %, (542±104) % and (786±132) % respectively, which was significantly different among three groups（P＜005）. The proportion of Treg in peripheral blood of normal pregnant women before pregnancy and at 12, 24,36 gestational weeks were （311±053）%,（643±114）%,（912±146）% and （1045±182）% respectively, which was significantly different among three groups（P＜005）. There was a significant positive correlation between MDSCs and Treg in peripheral blood (P<005). ConclusionThe high expression of MDSCs in pregnancy stimulates the differentiation of Treg cells to maintain maternal and fetal immune tolerance. Decreasing of MDSCs is a possible cause of URSA, which can be used as a target for clinical treatment.

参考文献/References:

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更新日期/Last Update: 2018-10-25