[1]李风艳,郭晶,王朝霞*.宫颈环形电切术术后宫颈粘连影响因素分析 及预防研究[J].中国计划生育和妇产科,2018,(8):26-29.
　LI Feng-yan,GUO Jing,WANG Zhao-xia*.Influencing factors analysis and prevention research of the cervical adhesion after LEEP[J].Chinese Journal of Family Planning & Gynecotokology,2018,(8):26-29.
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宫颈环形电切术术后宫颈粘连影响因素分析 及预防研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年8期
页码:
26-29
栏目:
论著与临床
出版日期:
2018-08-25

文章信息/Info

Title:
Influencing factors analysis and prevention research of the cervical adhesion after LEEP
作者:
李风艳1; 郭晶2;  王朝霞1*
1.山西医科大学第一医院妇科；2.太原市妇幼保健院妇产科
Author(s):
LI Feng-yan1;  GUO Jing2;  WANG Zhao-xia1*
1.Department of Gynecology,The First Hospital of Shanxi Medical University;2.Department of Gynecology and Obstetrics, Taiyuan Maternal and Child Healthcare Hospital,Taiyuan Shanxi 030001,P.R.China
关键词:
LEEP术; 重组人表皮生长因子; 宫颈粘连
Keywords:
LEEP;  recombinant human epidermal growth factor;  cervical adhesion
分类号:
R 711.32
摘要:
目的研究宫颈环形电切术（loop electrosurgical excision procedure，LEEP）后宫颈粘连的原因，探讨其预防方法。方法选择山西医科大学第一医院阴道镜室2010～2014年1 273例接受LEEP治疗的宫颈上皮内瘤变（cervical intraepithelial neoplasia，CIN）患者为研究对象。按照简单随机化分组方法分成两组。观察组给予重组人表皮生长因子浸润棉球湿敷宫颈［631例（失访113例）］；对照组给予碘伏液浸润棉球湿敷宫颈［642例（失访131例）］。术后随访宫颈粘连情况。结果本文纳入研究对象1 273例，手术后复查过程中失访244例。1 029例患者术后宫颈粘连共89例（86 %），其中94 %发生在术后3个月内。年龄、术中出血程度、术后感染为宫颈粘连的危险因素（OR>1，P<005），使用重组人表皮生长因子为保护因素（OR<1，P<005）。结论LEEP术后宫颈粘连发生率较高，应给予足够重视。宫颈粘连的发生与年龄、感染、术中出血多及术后用药有关，可从控制感染、减少出血、术后用药方面降低其发病率。
Abstract:
ObjectiveTo investigate the causes of cervical adhesion after loop electrosurgical excision procedure (LEEP) and to explore its prevention methods. Methods1 273 patients who underwent LEEP-treated cervical intraepithelial neoplasia (CIN) from 2010 to 2014 in The First Hospital of Shanxi Medical University were selected as subjects. According to the simple randomization grouping method, divided them into two groups. The observation group was given recombinant human epidermal growth factor infiltrating cotton ball wet cervix ［631 cases (113 cases lost)］; the control group was given iodophor infiltration cotton ball wet cervix ［642 cases (131 cases lost)］. Postoperative follow-up of cervical adhesions.ResultsThis article included 1 273 cases of study subjects, and lost 244 cases during the post-operative review. A total of 89 patients (8.6 %) had postoperative cervical adhesions in 1 029 patients, 94 % of which occurred within 3 months after surgery. Age, intraoperative bleeding, and postoperative infection were risk factors for cervical adhesions (OR>1, P<005), and using recombinant human epidermal growth factor was a protective factor(OR<1, P<005).ConclusionThe incidence of cervical adhesion after LEEP is high and should be given enough attention. The occurrence of cervical adhesions is related to age, infection, intraoperative bleeding and postoperative medication. It can reduce the incidence of infection, reducing bleeding and postoperative medication.

参考文献/References:

［1］Kyrgiou M, Athanasiou A, Kalliala IEJ, et al. Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease［J］ Cochrane Database of Systematic Reviews，2017,11(1):CD012847. ［2］Wang XI, Huang F, Zhang S. Loop electrosurgical excision procedure vs. cold knife cone in treatment of cervical intraepithelial neoplasia: Review of 447 cases［J］. Annals of clinical and laboratory science,2017, 47(6):663-667. ［3］KYRGIOU M, KOLIOPOULOS G, MARTIN-HIRSCH P, et al. Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions:systematic review and meta-analysis［J］. Lancet, 2006, 367(9509): 489-498. ［4］PARASKEVAIDIS E, KITCHENER H C, MILLER L D,et al. A population-based study of microinvasive disease of the cervix-a colposcopic and cytologic analysis［J］. Gynecologic Oncology, 1992, 47(10): 720-721. ［5］BAGGISH M S, BARASH F, NOEL Y， et al. Comparison of thermal injury zones in loop electrical and laser cervical excisional conization［J］. American Journal of Obstetrics and Gynecology, 1992, 166(2): 545-548. ［6］Song J S,Hwang I, Gong G, et al.Outcome of “atypical squamous cells” in cervical cytology:follow-up assessment by loop electrical excision procedure［J］.Korean Journal of Pathology, 2012,46(4):359-364. ［7］BJORGE T, SKARE G B, BJORGE L, et al.Adverse pregnancy outcomes after treatment for cervical intraepithelial neoplasia［J］. Obstetrics and Gynecology, 2016, 128(6): 1265-1273. ［8］ANDERSEN E S, PEDERSEN B, NIELSEN K. Laser conization:the results of treatment of cervical intraepithelial neoplasia［J］. Gynecologic Oncology, 1994, 54(2): 201-204. ［9］BOZANOVIC T, LJUBIC A, MOMCILOV P, et al. Csold-knife conization versus the loop electrosurgical excision procedure for treatment of cervical dysplasia［J］. European Journal of Gynaecological Oncology, 2008, 29(1): 83-85. ［10］Boulanger JC, Gondry J, Verhoest P,et al. Treatment of CIN after menopause ［J］. European Journal of Obstetrics, Gynecology and Reproductive Biology，2001, 95(2):175-180. ［11］SONG T, SEONG S J, KIM B G. Regeneration process after cervical conization for cervical intraepithelial neoplasia［J］. Obstetrics and Gynecology, 2016, 128(6): 1258-1264.

更新日期/Last Update: 2018-08-25