[1]洪玮,段华*,汪沙,等.BDNF及TrKB在子宫内膜异位症在位内膜和异位病灶组织中的表达及意义[J].中国计划生育和妇产科,2018,(3):32-36.
 HONG Wei,DUAN Hua*,WANG Sha,et al.Expression and significance of BDNF and TrKB in eutopic and ectopic endometrium of endometriosis[J].Chinese Journal of Family Planning & Gynecotokology,2018,(3):32-36.
点击复制

BDNF及TrKB在子宫内膜异位症在位内膜和异位病灶组织中的表达及意义
分享到:

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年3期
页码:
32-36
栏目:
论著与临床
出版日期:
2018-03-25

文章信息/Info

Title:
Expression and significance of BDNF and TrKB in eutopic and ectopic endometrium of endometriosis
作者:
洪玮段华*汪沙李金皎
首都医科大学附属北京妇产医院妇科微创中心
Author(s):
HONG Wei DUAN Hua* WANG Sha LI Jin-jiao
Gynecology Minimally Invasive Center,Beijing Obstetrics and Gynecology Hospital Affiliated of Capital Medical University,Beijing 100006,P.R.China
关键词:
子宫内膜异位症脑源性神经营养因子酪氨酸激酶受体B
Keywords:
endometriosis brain-derived neurotrophic factor tyrosine receptor kinase B
分类号:
R71171
摘要:
目的探讨脑源性神经营养因子(brain-derived neurotrophic factor, BDNF)及其受体酪氨酸激酶受体B(tyrosine receptor kinase B, TrKB)在子宫内膜异位症(endometriosis,EMS)在位内膜和卵巢异位病灶的表达,及其与分期和痛经的关系。方法选取2016年5月至11月在首都医科大学附属北京妇产医院妇科微创中心因卵巢EMS手术的患者40例,按r-AFS分期进行评分,其中Ⅲ期19例为Ⅲ期组,Ⅳ期21例为Ⅳ期组;并选取因卵巢良性上皮性肿瘤行手术的患者16例为对照组。采用免疫组化染色法检测Ⅲ期组和Ⅳ期组卵巢异位病灶、在位内膜与对照组子宫内膜中BDNF、TrKB水平,分析其与分期及痛经视觉模拟评分(visual analogue scale,VAS)的关系。结果 ① BDNF、TrKB在Ⅲ期组和Ⅳ期组在位内膜的表达分别为(19±03、22±04)、(20±03、23±02)。两两比较,Ⅳ期组均高于Ⅲ期组,并均高于两者在对照组子宫内膜的表达(12±01、12±01),差异均有统计学意义(P<005)。② BDNF、TrKB在Ⅲ期组和Ⅳ期组卵巢异位病灶的表达分别为(24±05、27±04)、(23±06、34±03)。两两比较,Ⅳ期组均高于Ⅲ期组,差异均有统计学意义(P<005)。③ BDNF、TrKB在Ⅲ期组和Ⅳ期组在位内膜的表达水平与痛经VAS评分呈正相关(r=0478、0386,P<005)。④ BDNF、TrKB在Ⅲ期组和Ⅳ期组的在位内膜、卵巢异位病灶的表达,增殖期与分泌期比较,差异均无统计学意义(P>005)。结论BDNF及TrKB随EMS病变程度加重其表达增加,推测BDNF及TrKB可能参与EMS的发生发展,在一定程度上参与EMS疼痛的发生。
Abstract:
ObjectiveTo investigate the expression of brain-derived neurotrophic factor(BDNF)and tyrosine receptor kinase B (TrKB) in endometriosis(EMS), and discuss the relationship between their expression and EMS stage or dysmenorrheal symptoms. Methods40 patients

参考文献/References:

[1]吴莎,华清泉,杨琨,等.脑源性神经营养因子研究进展 [J].中华临床医师杂志(电子版),2013,7(9):3988-3990. [2]SANTULLI P, MARCELLIN L, TOSTI C, et al. MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis? [J]. Expert Opinion on Therapeutic Targets, 2015, 19(11): 1465-1483. [3]BAI Huimin, LI Haixia, LI Weihua, et al. The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines [J]. Oncotarget, 2015, 6(28): 25520-25532. [4]LECONTE M, NICCO C, NG C, et al. The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice [J]. The American Journal of Pathology, 2011, 179(2): 880-889. [5]USUI T, NARUO A, OKADA M, et al. Brain-derived neurotrophic factor promotes angiogenic tube formation through Generation of oxidative stress in human vascular endothelial cells [J]. Acta Physiologica (Oxford, England), 2014, 211(2): 385-394. [6]BLAIS M, L VESQUE P, BELLENFANT S, et al. Nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and glial-derived neurotrophic factor enhance angiogenesis in a tissue-engineered in vitro model [J]. Tissue Engineering Part a, 2013, 19(15/16): 1655-1664. [7]KIM T H, YU Yanni, LUO L, et al. Activated AKT pathway promotes establishment of endometriosis [J]. Endocrinology, 2014, 155(5): 1921-1930. [8]中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南 [J].中华妇产科杂志,2015,50(3):161-169. [9]ANGER D L, ZHANG Bingjun, BOUTROSS-TADROSS O, et al. Tyrosine receptor kinase B (TrkB) protein expression in the human endometrium [J]. Endocrine, 2007, 31(2): 167-173. [10]BROWNE A S, YU Jie, HUANG Ruo-pan, et al. Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis [J]. Fertility and Sterility, 2012, 98(3): 713-719. [11]雍敏婕,李文倩,王芳,等.ER与TrkB在子宫内膜异位症患者不同子宫内膜组织中的表达 [J].国际妇产科学杂志,2015,42 (5):500-503. [12]RUIZ A, ROCKFIELD S, TARAN N, et al. Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis [J]. Cell Death & Disease, 2016, 7(1): e2059. [13]TAYLOR R N, YU Jie, TORRES P B, et al. Mechanistic and therapeutic implications of angiogenesis in endometriosis [J]. Reproductive Sciences, 2009, 16(2): 140-146. [14]Borghese B, Vaiman D, Mondon F, et al. Neurotrophins and pain in endometriosis [J]. Gynecol Obstet Fertil,2010,38(7-8):442-446. [15]MOROTTI M, VINCENT K, BRAWN J, et al.Peripheral changes in endometriosis-associated pain [J]. Human Reproduction Update, 2014, 20(5): 717-736. [16]代淑红,马正良.钾氯共转运体-2和痛觉过敏关系的研究进展 [J].国际麻醉学与复苏杂志,2015,36(6):543-546. [17]WESSELS J M, LEYLAND N A, AGARWAL S K. Estrogen induced changes in uterine brain-derived neurotrophic factor and its receptors [J]. Human Reproduction, 2015, 30(4): 925-936. [18]WESSELS J M, KAY V R, LEYLAND N A, et al. Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis [J]. Fertility and Sterility, 2016, 105(1): 119-128.e1.

相似文献/References:

[1]苏慧明,徐燕,李晶,等.E-钙粘附素在子宫内膜异位症盆腔腹膜病灶的表达[J].中国计划生育和妇产科,2010,(01):0.
 SU Hui-ming,XU Yan,LI Jing,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2010,(3):0.
[2]李桂兰.青春期子宫内膜异位症的诊治进展[J].中国计划生育和妇产科,2010,(03):0.
[3]韦晓娜,覃红萍.孕三烯酮配伍小剂量米非司酮治疗子宫内膜异位症64例效果观察[J].中国计划生育和妇产科,2010,(04):0.
[4]李成龙,冷金花.子宫内膜异位症与雌、孕激素受体关系的研究进展[J].中国计划生育和妇产科,2010,(04):0.
[5]关铮.深部浸润型子宫内膜异位症相关问题探讨[J].中国计划生育和妇产科,2011,(04):0.
[6]张瑞霞,刘增娟,谢伟,等.腹腔镜诊断盆腔子宫内膜异位症及对不孕症患者的疗效观察[J].中国计划生育和妇产科,2012,(02):0.
 ZHANG Rui-xia,LIU Zeng-juan,XIE Wei,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2012,(3):0.
[7]梁寿珺,范余娟,黄尹,等.血管内皮生长因子+936TC基因多态性同子宫内膜异位症遗传易感性的Meta分析[J].中国计划生育和妇产科,2012,(04):0.
 LIANG Shou-jun,FAN Yu-juan*,HUANG Yin,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2012,(3):0.
[8]范俊,栾少红,李晓林,等.口服避孕药在子宫内膜异位症治疗中的作用[J].中国计划生育和妇产科,2013,(02):0.
 FAN Jun,LUAN Shao-hong,LI Xiao-lin,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2013,(3):0.
[9]柴明涵,董白桦.左炔诺孕酮宫内缓释系统的临床应用[J].中国计划生育和妇产科,2014,(03):0.
[10]李素红,冯春蝶,付秀虹,等.Treg细胞及Foxp3在子宫内膜异位症患者的表达及临床意义[J].中国计划生育和妇产科,2014,(04):0.
 LI Su-hong,FENG Chun-die,FU Xiu-hong,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[11]洪玮,段华*,汪沙.脑源性神经营养因子与受体在子宫内膜异位症 发生发展及相关症状中作用的研究进展[J].中国计划生育和妇产科,2017,(3):27.
[12]吴亚男,李红霞*,孟宪宁,等.子宫内膜异位症及卵巢癌患者血清脑源性神经营养因子水平的表达及意义[J].中国计划生育和妇产科,2018,(9):32.
 WU Ya-nan,LI Hong-xia*,MENG Xian-ning,et al.Expression and significance of serum BDNF in patients with endometriosis and ovarian cancer[J].Chinese Journal of Family Planning & Gynecotokology,2018,(3):32.

备注/Memo

备注/Memo:
国家自然科学基金资助项目(项目编号:81571412);北京市医院管理局重点医学专业发展项目(项目编号:ZYLX201406);首都医科大学基础-临床科研合作基金(项目编号:16JL44)
更新日期/Last Update: 2018-03-25