[1]董千靖,段华*,郑德璇,等.结缔组织生长因子、整合素αvβ3在子宫腺肌病中的表达及相关性研究[J].中国计划生育和妇产科,2018,(3):27-31.
 DONG Qian-jing,DUAN Hua*,ZHENG De-xuan,et al.Expression of CTGF and integrin αvβ3 in adenomyosis and its correlation[J].Chinese Journal of Family Planning & Gynecotokology,2018,(3):27-31.
点击复制

结缔组织生长因子、整合素αvβ3在子宫腺肌病中的表达及相关性研究
分享到:

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年3期
页码:
27-31
栏目:
论著与临床
出版日期:
2018-03-25

文章信息/Info

Title:
Expression of CTGF and integrin αvβ3 in adenomyosis and its correlation
作者:
董千靖段华*郑德璇甘露沈雪汪沙
首都医科大学附属北京妇产医院妇科微创中心
Author(s):
DONG Qian-jing DUAN Hua* ZHENG De-xuan GAN Lu SHEN Xue WANG Sha
Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, P.R.China
关键词:
子宫腺肌病结缔组织生长因子整合素αvβ3
Keywords:
adenomyosis connective tissue growth factor integrin αvβ3
分类号:
R 711.71
摘要:
目的探讨结缔组织生长因子(connective tissue growth factor, CTGF)和整合素αvβ3在子宫腺肌病(adenomyosis,ADS)中的表达及相关性。方法选取2015年7月至2016年12月于首都医科大学附属北京妇产医院妇科微创中心因ADS行全子宫切除术的患者30例为ADS组,同期因宫颈上皮内瘤变Ⅲ 级行全子宫切除术的患者28例为对照组,获取子宫内膜组织,应用免疫组化法检测两组子宫内膜组织中CTGF和整合素αvβ3表达。结果① CTGF、整合素αvβ3在ADS组异位内膜的表达(024±004、022±007)高于在位内膜(016±003、011±004)及对照组子宫内膜(019±002、014±003)(P<005);且两者在 ADS组及对照组中均呈正相关(ADS组r =055,对照组r =059,P<005);② CTGF、整合素αvβ3在ADS组异位内膜和在位内膜中的表达,增殖期(024±004、021±003和016±003、009±004)与分泌期(024±003、022±009和016±003、012±003)比较,差异无统计学意义(P>005) 结论CTGF和整合素αvβ3在ADS表达失去月经周期性,异位内膜中表达异常增高且两者存在正相关,提示CTGF和整合素αvβ3可能共同参与了ADS的发生发展。
Abstract:
ObjectiveTo investigate the expression of connective tissue growth factor(CTGF) and integrin αvβ3 in the patients with adenomyosis(ADS) and discuss its relationship. Methods30 ADS patients who had hysterectomy from July, 2015 to December, 2016 in Gynecolo

参考文献/References:

[1]Barreto SC, Ray A, Ag Edgar P. Biological characteristics of CCN proteins in tumor development [J]. J BUON, 2016, 21(6): 1359-1367. [2]ADACHI Masatake, Nasu K, Tsuno A, et al. Attachment to extracellular matrices is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis [J]. Eur J Obstet Gynecol Reprod Biol, 2011, 155(1): 85-88. [3]Tan TW, Lai CH, Huang CY, et al. CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells [J]. J Cell Biochem, 2009, 107(2): 345-356. [4]Yeger H, Perbal B. CCN family of proteins: critical modulators of the tumor cell microenvironment [J]. J Cell Commun Signal, 2016, 10(3): 229-240. [5]WU Yu-ling, LI Hong-yu, ZHAO Xiao-peng, et al. Mesenchymal stem cell-derived CCN2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells [J]. Cancer Sci, 2017, 108(5): 897-909. [6]Alam KJ, MO Ji-su, Han SH, et al. MicroRNA 375 regulates proliferation and migration of colon cancer cells by suppressing the CTGF-EGFR signaling pathway [J]. International Journal of Cancer, 2017, 141(8): 1614-1629. [7]SUI Cong, Mecha E, Omwandho CO, et al. PAI-1 secretion of endometrial and endometriotic cells is Smad2/3- and ERK1/2-dependent and influences cell adhesion [J]. Am J Transl Res, 2016, 8(5): 2394-2402. [8]Au HK, Chang JH, Wu YC, et al. TGF-βI regulates cell migration through pluripotent transcription factor OCT4 in endometriosis [J]. PLoS One, 2015, 10(12): e0145256. [9]YU Yue-xin, XIU Yin-ling, CHEN Xi, et al. Transforming growth factor-beta 1 involved in the pathogenesis of endometriosis through regulating expression of vascular endothelial growth factor under hypoxia [J]. Chin Med J (Engl), 2017, 130(8): 950-956. [10]SHEN Minhong, LIU Xishi, ZHANG Hongqi, et al. Transforming growth factor β1 signaling coincides with epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice [J]. Hum Reprod, 2016, 31(2): 355-369. [11]Kerr JS, Mousa SA, Slee AM. Alpha(v)beta(3) integrin in angiogenesis and restenosis [J]. Drug News Perspect, 2001, 14(3): 143-150. [12]李爱华,刘风青,靳卫国.子宫内膜异位症患者组织中骨桥蛋白及配体整合素αVβ3的表达及对血管生成的影响 [J].中国妇产科临床杂志,2013,14(6):533-535. [13]ZHU Jian-hua, YUAN Ye, LI Dong, et al. Targeting nuclear factor-κB suppresses the negative effect of toll-like receptor 4 signaling on antimetastasis therapy based on targeting αvβ3 [J]. Cancer Sci, 2012, 103(7): 1319-1326. [14]Meldolesi J. Pharmacology of the cell/matrix form of adhesion [J]. Pharmacological Research, 2016, 107(10): 430-436. [15]李玉芳,陈晓燕,刘美霞.整合素α ν β 3在子宫内膜异位症中表达的意义 [J].中国妇幼保健,2009,16(24):2273-2274. [16]Tan TW, Lai CH, Huang CY, et al. CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells [J]. J Cell Biochem, 2009, 107(2): 345-356. [17]Maybin JA, Barcroft J, Thiruchelvam U, et al. The presence and regulation of connective tissue growth factor in the human endometrium [J]. Hum Reprod, 2012, 27(4): 1112-1121. [18]NAGASHIMA Takashi, Kim J, LI Qinglei, et al. Connective tissue growth factor is required for normal follicle development and ovulation [J]. Mol Endocrinol, 2011, 25(10): 1740-1759. [19]Waddell JM, Evans J, Jabbour HN, et al. CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8/Svneo cell adhesion and network formation [J]. Hum Reprod, 2011, 26(1): 67-75. [20]隋晓倩,于德钦,张冬梅.子宫内膜容受性各相关标志物研究进展 [J].生殖与避孕,2015,35(3):185-190.

相似文献/References:

[1]柴明涵,董白桦.左炔诺孕酮宫内缓释系统的临床应用[J].中国计划生育和妇产科,2014,(03):0.
[2]苏慧明,徐燕,黎颖雄,等.诺舒子宫内膜去除术治疗子宫腺肌病致月经过多的临床研究[J].中国计划生育和妇产科,2014,(03):0.
 SU Hui-ming,XU Yan,LI Ying-xiong,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[3]毛世华,谭晓燕,范玲,等.高强度聚焦超声联合米非司酮治疗子宫腺肌病的疗效观察[J].中国计划生育和妇产科,2014,(05):0.
 MAO Shi-hua,TAN Xiao-yan,FAN Ling,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[4]邓淑珍.曼月乐宫内节育器治疗子宫腺肌病的疗效观察[J].中国计划生育和妇产科,2014,(05):0.
 DENG Shu-zhen,[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[5]王宇慧,魏绍斌.中成药治疗子宫内膜异位症和子宫腺肌病的辨证应用[J].中国计划生育和妇产科,2015,(02):0.
[6]邓云,丁惠,许永华,等.高强度聚焦超声治疗子宫腺肌病病灶消融率影响因素分析[J].中国计划生育和妇产科,2015,(06):0.
 DENG Yun,DING Hui,XU Yong-hua,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(3):0.
[7]孙馥箐,段华,叶红,等.双子宫畸形伴双侧子宫腺肌病与左侧子宫肌瘤1例并文献复习[J].中国计划生育和妇产科,2016,(04):0.
[8]李金皎,段华,汪沙,等.子宫腺肌病患者子宫肌层平滑肌细胞生长状态与增殖特点的研究[J].中国计划生育和妇产科,2016,(05):0.
 LI Jin-jiao,DUAN Hua,WANG Sha,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(3):0.
[9]李晓欣,张萍,张纯溪,等.促性腺激素释放激素激动剂联合腹腔镜手术治疗大子宫腺肌病疗效的研究[J].中国计划生育和妇产科,2016,(07):0.
 LI Xiao-xin,Zhang Ping,Zhang Chun-xi,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(3):0.
[10]贾晨阳,段华,汪沙,等.血管形成相关因子在子宫腺肌病发病中作用的研究进展[J].中国计划生育和妇产科,2016,(08):0.
 JIA Chen-yang,DUAN Hua,WANG Sha,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(3):0.

备注/Memo

备注/Memo:
国家自然科学基金(项目编号:81571412);北京市医院管理局临床医学发展专项-“扬帆计划”(项目编号:ZYLX201406);首都医科大学基础-临床科研合作基金(项目编号:16JL44)
更新日期/Last Update: 2018-03-25