[1]刘新娟,黎东梅,王静,等.绝经后女性骨质疏松症与胰岛素样生长因子关系的临床研究[J].中国计划生育和妇产科,2018,(12):76-78,96.
 LIU Xin-juan,LI Dong-mei,WANG Jing,et al.Clinical study of relationship between osteoporosis and insulin-like growth factor in postmenopausal women[J].Chinese Journal of Family Planning & Gynecotokology,2018,(12):76-78,96.
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绝经后女性骨质疏松症与胰岛素样生长因子关系的临床研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年12期
页码:
76-78,96
栏目:
论著与临床
出版日期:
2018-12-25

文章信息/Info

Title:
Clinical study of relationship between osteoporosis and insulin-like growth factor in postmenopausal women
作者:
刘新娟黎东梅王静张栋武*
佛山市高明区人民医院妇产科
Author(s):
LIU Xin-juanLI Dong-meiWANG JingZHANG Dong-wu*
Department of Gynecology and Obstetrics,Foshan City Gaoming District People's Hospital,Foshan Guangdong 528500, P.R.China
关键词:
绝经后妇女骨质疏松症胰岛素样生长因子-1125-(OH)2-VitD3
Keywords:
postmenopausal women osteoporosis insulin-like growth factor-1(IGF-1) 125(OH)2 Vit D3
分类号:
R 5895
摘要:
目的探讨绝经后女性骨质疏松症与胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)的内在联系,为治疗绝经后女性骨质疏松症提供依据。方法选取2016年6月至2017年10月于佛山市高明区人民医院健康体检的125例绝经后妇女2~4腰椎(L2~L4)处的骨密度(bone mineral density,BMD)、全髋部BMD进行测定,并检测血清IGF-1、1,25-二羟维生素D3(1,25-(OH)2-VitD3)含量。其中65名诊断为骨质疏松症的患者为研究组,其他60名绝经妇女为对照组,比较两组前述指标并进行相关性分析。结果研究组腰椎及髋部BMD、IGF-1、1,25-(OH)2-VitD3含量明显低于对照组,差异有统计学意义(P<005);血清IGF-1与BMD呈明显正相关(r=0571,P<005)。结论血清IGF-1及1,25-(OH)2 -VitD3含量降低可能在绝经后女性骨质疏松症的发病机制中发挥重要作用。
Abstract:
ObjectiveTo investigate the intrinsic relationship between osteoporosis and insulin-like growth factor 1 (IGF-1) in postmenopausal women. MethodsSelected 125 postmenopausal women who had physical examinations in Gaoming District People's Hospital from June 2016 to October 2017. Their bone mineral density (BMD) at lumbar spine 2~4 (L2~L4) and total hip bone mineral density (BMD) were measured. Serum IGF-1 and 1, 25(OH)2 Vit D3 was detected,too. 65 women with osteoporosis were set as study group and 60 normal elderly menopausal women as control group. Compared above indicators of the two groups and performed correlation analysis. ResultsThe levels of BMD at lumbar spine and total hip bone, IGF-1, 1,25-(OH)2-VitD3 of the study group were significantly lower than those in the control group (P<005). The serum IGF-I was positively correlated with BMD (r= 0571, P<005).ConclusionDecreased levels of serum IGF-1 and 1, 25(OH)2 Vit D3 may play an important role in the pathogenesis of postmenopausal women with osteoporosis.

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备注/Memo

备注/Memo:
佛山市科技局医学类科技攻关项目(项目编号:20161021040004 );佛山市十三五医学重点专科培育项目(项目编号:FSZDZK135058);高明区十三五医学重点专科资助项目(项目编号:GMGSPZD13504)
更新日期/Last Update: 2018-12-25