[1]王迎辉a*,王丽娟b,王丽霞.黏蛋白1和黏蛋白5 AC在子宫内膜癌组织中的表达及临床意义[J].中国计划生育和妇产科,2018,(7):28-32.
　WANG Ying-huia*,WANG Li-juanb,WANG Li-xia.Expression and clinical significance of MUC 1 and MUC 5 AC in endometrial cancer[J].Chinese Journal of Family Planning & Gynecotokology,2018,(7):28-32.
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黏蛋白1和黏蛋白5 AC在子宫内膜癌组织中的表达及临床意义
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年7期
页码:
28-32
栏目:
论著与临床
出版日期:
2018-07-25

文章信息/Info

Title:
Expression and clinical significance of MUC 1 and MUC 5 AC in endometrial cancer
作者:
王迎辉1a*; 王丽娟1b; 王丽霞2
1.253600山东乐陵,乐陵市人民医院，a.妇科; b.产科; 2. 300110天津,天津市黄河医院妇产科
Author(s):
WANG Ying-hui1a*;  WANG Li-juan1b;  WANG Li-xia2
1a.Department of Gynecology;b.Department of Obstetrics,Leling People's Hospital,Leling Shandong 253600,P.R.China;2. Department of Gynecology and Obstetrics,Tianjin Yellow River Hospital,Tianjin 300110,P.R.China
关键词:
子宫内膜癌; 黏蛋白1; 黏蛋白5AC; 临床病理参数
Keywords:
endometrial carcinoma;  MUC 1;  MUC 5AC;  clinical pathological parameters
分类号:
R 737.33
摘要:
目的检测黏蛋白（mucin,MUC）1、MUC 5 AC在子宫内膜癌（endometrial cancer,EC）组织中的表达情况，探讨两者与临床病理参数及预后之间的关系。方法收集2011年5月至2014年5月在乐陵市人民医院确诊并治疗的83例EC标本作为研究对象，选取同期75例非典型增生子宫内膜标本和70例正常子宫内膜标本作为对照。采用免疫组化法检测不同子宫内膜组织中MUC 1、MUC 5 AC蛋白的表达水平，分析MUC 1、MUC 5 AC蛋白表达与EC各项临床病理参数及预后之间的关系。结果MUC 1、MUC 5 AC在EC、非典型增生内膜及正常子宫内膜组织中阳性率逐渐降低，两两比较差异有统计学意义（P＜005）。MUC 1表达与EC患者FIGO分期、病理分级、淋巴结转移及肌层浸润有关(P＜005)；MUC 5 AC表达与EC患者FIGO分期、病理分级有关(P＜005)。MUC 1阳性表达EC者3年存活率显著低于MUC 1阴性表达者（5217 %vs 8571 %，P＜005）；MUC 5 AC阳性表达EC者3年存活率明显低于MUC 5 AC阴性表达者（4655 %vs 8800 %，P＜005）。结论MUC 1、MUC 5 AC在EC组织中高表达，与肿瘤恶性程度及患者预后有关。
Abstract:
ObjectiveTo detect the expressions of mucin 1(MUC 1) and mucin 5AC(MUC 5AC) in endometrial cancer(EC) tissues, and to explore the relationships between the two with the clinical pathological parameters and prognosis. Methods83 specimens of EC, which were diagnosed and treated in Leling People's Hospital from May 2011 to May 2014, were collected as the research subjects. In the same period, 75 specimens of atypical hyperplasia of endometrium and 70 specimens of normal endometrium were selected as control. The expression of MUC 1 and MUC 5AC protein in different endometrium tissues was detected by immunohistochemistry, the relationships between the expression of MUC 1 and MUC 5AC protein with the clinicopathological parameters and prognosis of EC were analyzed. ResultsThe positive rates of MUC 1 and MUC 5AC in EC, atypical endometrium and normal endometrium were gradually decreased, the differences between each two were statistically significant(P<005). The expression of MUC 1 was related to FIGO staging, pathological grading, lymph node metastasis and myometrium infiltration in EC patients(P<005); the expression of MUC 5AC was related to the FIGO staging and pathological classification of EC patients (P<005). The 3 year survival rate of MUC 1 positive expression EC patients was significantly lower than that of MUC 1 negative expression EC patients (5217 %vs 8571 %, P<005); the 3 year survival rate of MUC 5AC positive expression EC patients was significantly lower than that of MUC 5AC negative expression EC patients (4655 % vs 88 %, P<005). ConclusionMUC 1 and MUC 5AC are highly expressed in EC tissues.It is related to the malignancy of the tumor and the prognosis of the patients.

参考文献/References:

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更新日期/Last Update: 2018-07-25