[1]南燕燕,李娜,李岩*,等.孕期血脂水平对妊娠期并发症及子代的影响[J].中国计划生育和妇产科,2019,(6):63-66,71.
　NAN Yan-yan,LI Na,LI Yan*,et al.Effect of blood lipid levels during pregnancy on pregnancy complications and offspring[J].Chinese Journal of Family Planning & Gynecotokology,2019,(6):63-66,71.
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孕期血脂水平对妊娠期并发症及子代的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年6期
页码:
63-66,71
栏目:
论著与临床
出版日期:
2019-06-25

文章信息/Info

Title:
Effect of blood lipid levels during pregnancy on pregnancy complications and offspring
作者:
南燕燕; 李娜; 李岩*; 王同娜; 李秀琴
衡水市第二人民医院产科
Author(s):
NAN Yan-yan; LI Na; LI Yan*;  WANG Tong-na;  LI Xiu-qin
Department of Obstetrics, the Second People’s Hospital of Hengshui, Hengshui Hebei 053000,P.R.China
关键词:
妊娠期并发症; 血脂; 新生儿结局
Keywords:
pregnancy complication; blood lipid; neonatal outcome
分类号:
R 714.25
摘要:
目的探讨孕期血脂水平对妊娠期并发症及子代的影响。方法 回顾性分析2014年2月至2016年1月于衡水市第二人民医院建档、待产至分娩的200例孕妇的临床资料，包括其孕早期（孕10~12周）、孕晚期（孕36~37周）血清总胆固醇（total cholesterol,TC）、甘油三酯（triglyceride,TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol,LDL-C）、载脂蛋白A（Apolipoprotein A,ApoA）、载脂蛋白B（Apolipoprotein B,ApoB）水平。追踪围产期并发症发生情况，按是否发生妊娠期并发症分为并发症组与无并发症组。比较两组孕期母体血脂水平，并按血脂水平分组，比较不同血脂水平孕妇新生儿状况及母儿并发症发生率。均随访至新生儿出生3个月，测定子代出生4周、12周血糖、血脂水平。结果孕早期、孕晚期孕妇HDL-C、ApoA、ApoB水平比较，差异无统计学意义（P>005）；孕晚期，孕妇TC、TG、LDL-C均上升，与孕早期比较差异有统计学意义（P<005）；200例孕妇围产期发生并发症32例（1600 %），并发症孕妇TC、TG、LDL-C、ApoA均高于无并发症孕妇（P<005）；妊娠期并发症组血脂异常检出率（7813 %）高于无并发症组（1131 %）（P<005）；血脂异常组新生儿出生体质量、巨大儿发生率高于血脂正常组（P<005）；血脂异常组新生儿出生4周、12周TC、TG水平均高于血脂正常组新生儿（P<005）。结论孕晚期孕妇高血脂可能增加妊娠期并发症及巨大儿发生风险，导致子代血脂代谢异常。
Abstract:
ObjectiveTo investigate the effect of blood lipid levels during pregnancy on pregnancy complications and offspring. MethodsRetrospective analysis of the clinical data of 200 pregnant women who were filed and delivered in the Second People's Hospital of Hengshui from February 2014 to January 2016,including the early pregnancy (10~12 weeks pregnant), the third trimester (36~37 weeks of pregnancy) serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol （HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), and apolipoprotein B (ApoB) levels. The perinatal complications were followed up and classified into the complication group and the non-complication group according to whether complications occurred during pregnancy. The maternal blood lipid levels in the two groups were compared and grouped according to the blood lipid levels to compare the neonatal status and the incidence of maternal and child complications in different blood lipid levels. All were followed up to 3 months after birth, and the blood glucose and blood lipid levels of the offspring were measured at 4 weeks and 12 weeks. ResultsThere were no significant differences in HDL-C, ApoA and ApoB levels between pregnant women and pregnant women in the first trimester and the third trimester (P>005). In the third trimester, TC, TG and LDL-C increased in pregnant women, and the difference was statistically significant compared with the early pregnancy(P<005); There were 32 cases of complications in the perinatal period of pregnant women (1600 %). The TC, TG, LDL-C and ApoA of the pregnant women were higher than those of the uncomplicated pregnant women (P<005). The detection rate of dyslipidemia in the gestational complications group was higher (7813 %) than in the non-complication group (1131 %) (P<005). The neonatal birth weight and incidence of macrosomia of the dyslipidemia group were higher than those of the normal lipid group (P<005). The TC and TG levels in the dyslipidemia group were higher than those in the normal blood lipid group at 4 and 12 weeks (P<005).ConclusionHyperlipidemia in pregnant women in the third trimester may increase the complications of pregnancy and the risk of macrosomia, leading to abnormal metabolism of blood lipids in offspring.

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更新日期/Last Update: 2019-06-25