[1]赵晓曦*,武艾宁,于荣鑫,等.染色体三体妊娠发生相关因素病例-对照研究[J].中国计划生育和妇产科,2019,(7):63-66.
　ZHAO Xiao-xi*,WU Ai-ning,YU Rong-xin,et al.Case-control study on factors related to chromosome trisomic pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2019,(7):63-66.
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染色体三体妊娠发生相关因素病例-对照研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年7期
页码:
63-66
栏目:
论著与临床
出版日期:
2019-06-25

文章信息/Info

Title:
Case-control study on factors related to chromosome trisomic pregnancy
作者:
赵晓曦*; 武艾宁; 于荣鑫; 万骁文
内蒙古医科大学附属医院妇产科
Author(s):
ZHAO Xiao-xi*;  WU Ai-ning;  YU Rong-xin;  WAN Xiao-wen
Department of Obstetrics and Gynecology,Affiliate Hospital of Inner Mongolia Medical University, Hohhot Inner Mongolia 010050,P.R.China
关键词:
三体妊娠; 盆腔手术史; 月经不规律; 卵巢功能
Keywords:
trisomic pregnancy; history of pelvic surgery; irregular menstruation; ovarian function
分类号:
R 714.2
摘要:
目的通过对比胎儿染色体正常孕妇与胎儿染色体核型为标准三体孕妇在妊娠方式、盆腔手术史、月经是否规律、正常生育次数、自然流产次数、人工流产次数、毒物接触史等方面是否存在差异，了解三体妊娠发生的高危因素。方法从2011年1月至2018年2月在内蒙古医科大学附属医院妇产科行羊水穿刺的1 098例患者中，选取标准三体妊娠孕妇77例作为研究组，为每位孕妇选择1名与其年龄相同，胎儿染色体正常的孕妇做对照组。通过条件逻辑回归分析，比较两组间是否在妊娠方式、盆腔手术史、月经是否规律、正常生育次数、自然流产次数、人工流产次数、毒物接触史方面存在差异。结果条件逻辑回归分析结果显示，月经不规律与三体妊娠发生存在关联（OR=5596；95 %CI 1921-17196，P=0003）；在三体妊娠组中，有盆腔手术史者的比例（117 %）高于对照组（37 %），但差异无统计学意义（P=0057）。结论月经不规律是三体妊娠发生的高危因素，有盆腔手术史较无盆腔手术史易发生三体妊娠。
Abstract:
Objective To study the risk factors associated with trisomic pregnancy, we examined the differences between women with trisomic pregnancies and women with chromosomally normal pregnancies in terms of menstrual history, family history, history of pelvic surgery, assisted reproduction, and history of toxin exposure. MethodsFrom January 2011 to February 2018, 1 098 patients underwent amniocentesis in the Obstetrics and Gynecology Department of the Affiliated Hospital of Inner Mongolia medical university. In 1 098 patients underwent amniocentesis, 77 trisomic pregnant women were selected as the study group. The 77 control group was selected for each pregnant woman of the same age with normal fetal chromosomes. Logistic regression analysis was conducted using statistical software. ResultsThe results of conditional logistic regression analysis showed that there was an association between irregular menstruation and trisomic pregnancy (OR=5596； 95 % CI 1921-17196, P=0003). The women with a history of pelvic surgery in the trisomic pregnancy group were significantly higher than those in the control group (117 % in the trisomic pregnancy group, 37 % in the control group,P=0057). ConclusionIrregular menstruation is a high risk factor for trisomic pregnancy. Women with a history of pelvic surgery are more prone to trisomic pregnancy than those without a history of pelvic surgery.

参考文献/References:

［1］JENDERNY J. Chromosome aberrations in a large series of spontaneous miscarriages in the German population and review of the literature ［J］. Molecular Cytogenetics, 2014, 7(38): 1-9. ［2］PYLYP L Y, SPYNENKO L O, VERHOGLYAD N V, et al. Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases ［J］. Journal of Assisted Reproduction and Genetics, 2018, 35(2): 265-271. ［3］BHAUMIK P, BHATTACHARYA M, GHOSH P, et al. Telomere length analysis in Down syndrome birth ［J］. Mech Ageing Dev, 2017, 164: 20-26. ［4］Honorato TC,Henningsen AA,Haadsma ML,et al. Follicle pool, ovarian surgery and the risk for a subsequent trisomic pregnancy ［J］. Hum Reprod, 2015, 30(3):717-722. ［5］FU X, CHENG J, HOU Y, et al. The association between the oocyte pool and aneuploidy:a comparative study of the reproductive potential of young and aged mice ［J］. Journal of Assisted Reproduction and Genetics, 2014, 31(3): 323-331. ［6］MATZUK M M, LAMB D J. The biology of infertility: research advances and clinical challenges ［J］. Nature Medicine, 2008, 14(11, S): 1197-1213. ［7］HONORATO T, HOEK A, HENNINGSEN A， et al. Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy ［J］. Reproductive BioMedicine Online, 2017, 35(6): 685-692. ［8］BURGER H G, HALE G E, DENNERSTEIN L, et al. Cycle and hormone changes during perimenopause: the key role of ovarian function ［J］. Menopause (New York, N.Y.), 2008, 15(4 Pt 1): 603-612. ［9］GLEICHER N,KUSHNIR V,LAZZARONI E et al.Clinical relevance of combined FSH and AMH observations in infertile women ［J］. J Clin Endocrinol Metab,2013,98(5):2136-2145. ［10］ROBERTS R,IATROPOULOU A,CIANTAR D,et al.Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro ［J］. Biol Reprod, 2004, 72(1):107-118. ［11］MERMILLOD P, DALBIES-TRAN R, UZBEKOVA S, et al. Factors affecting oocyte quality: Who is driving the follicle? ［J］. Reproduction in Domestic Animals, 2008, 43(2): 393-400. ［12］MIHLAS BP,REDGROVE KA,MCLAUGHLIN EA,et al. Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage［J］.Oxid Med Cell Longev, 2017, 2017:4015874. ［13］VAN BLERKOM J. Epigenetic influences on oocyte developmental competence: perifollicular vascularity and intrafollicular oxygen［J］. J Assist Reprod Genet, 1998,15(5):226-234.

备注/Memo

备注/Memo:
国家自然科学基金 （项目编号：81660542） ；内蒙古自然科学基金（项目编号：2018MS08091）
更新日期/Last Update: 2019-07-25