[1]朵雪莲*,马梅艳,白盖措.盆腔淋巴结切除数目对不同治疗方案的宫颈癌患者无进展生存时间的影响[J].中国计划生育和妇产科,2019,(9):47-52.
　DUO Xue-lian*,MA Mei-yan,BAI Gai-cuo.Effect of number of pelvic lymph node resection on progression-free survival of cervical cancer patients with different treatment regimens[J].Chinese Journal of Family Planning & Gynecotokology,2019,(9):47-52.
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盆腔淋巴结切除数目对不同治疗方案的宫颈癌患者无进展生存时间的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年9期
页码:
47-52
栏目:
论著与临床
出版日期:
2019-09-25

文章信息/Info

Title:
Effect of number of pelvic lymph node resection on progression-free survival of cervical cancer patients with different treatment regimens
作者:
朵雪莲*; 马梅艳; 白盖措
青海省妇幼保健院妇产科
Author(s):
DUO Xue-lian*; MA Mei-yan; BAI Gai-cuo
Department of Obstetrics and Gynecology, Qinghai Maternal and Child Health Hospital, Xining Qinghai 810000,P.R.China
关键词:
宫颈肿瘤; 进展生存时间; 新辅助化疗
Keywords:
cervical neoplasms; progressive survival time; neoadjuvant chemotherapy
分类号:
R 737.33
摘要:
目的探讨盆腔淋巴结切除数目对不同治疗方案的宫颈癌患者无进展生存时间（progression-free-survival,PFS）的影响。方法收集2009年1月至2016年1月青海省妇幼保健院收治的725例宫颈癌患者的病例资料，根据术前是否接受新辅助化疗，将患者分为直接手术（primary surgical treatment，PST）组及新辅助化疗后再手术（neoadjuvant chemotherapy followed by surgery，NCS）组，比较不同淋巴结切除数目对患者预后的影响。结果① 341例（470 %）患者接受了术后补充治疗。NCS组患者的高危因素明显多于PST组（P＜005），但中危因素差异无统计学意义（P＞005）。② PST组、NCS组分别平均有（023±017）枚、（026±021）枚淋巴结存在转移，术中分别平均切除（248±942）枚、（259±964）枚淋巴结。两组患者的淋巴结转移数目、切除数目相比较，差异无统计学意义（P＞005）。③ 生存分析显示，在NCS组中，淋巴结转移数量≥2的患者预后较差（P＜005）。但在PST组中，淋巴结转移数量对患者预后无明显影响（P＞005）。④ 在NCS组中，与淋巴结切除数目＜19枚的患者相比，切除数目≥19枚的患者预后明显较好（P＜005）。但在PST组中，增加淋巴结切除数量并未使患者生存获益（P＜005）。⑤ 对PST组中淋巴结转移数量≥2枚的患者而言，增加淋巴结切除数量仍未使患者获得明显的生存收益（P＞005）。但在NCS组中，淋巴结切除数量≥19枚的患者预后显著好于切除数量<19枚的患者（P＜005），这种生存获益的趋势比淋巴结切除数量对NCS组总体生存率的影响更为显著。⑥ 多因素分析显示，仅有淋巴结转移、切缘情况是影响NCS组患者预后的独立性危险因素（P＜005）。结论对接受新辅助化疗的早期宫颈癌患者，增加淋巴结切除数量可有更好的生存获益。
Abstract:
ObjectiveTo investigate the effect of the number of pelvic lymph node resection on progression-free survival(PFS) in cervical cancer patients with different treatment regimens. MethodsThe clinical data of 725 patients with cervical cancer admitted to Qing

参考文献/References:

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更新日期/Last Update: 2019-09-25