参考文献/References:
［1］Walker GJ，Gunasekera P Pelvic organ prolapse and incontinence in developing countries: review of prevalence and risk factors ［J］. Int Urogynecol J，2011，22(2): 127-135.
［2］朱兰，郎景和．女性盆底学 ［M］．北京：人民卫生出版社，2008．
［3］Hallock JL，Handa VL. The epidemiology of pelvic floor disorders and childbirth: an update［J］. Obstet Gynecol Clin North Am，2016，43(1): 1-13.
［4］Altman D，Forsman M，Falconer CA. Genetic influence on Stress Urinary Incontinence and Pelvic Organ Prolapse［J］. Eur Urol，2008，54(4): 918-923.
［5］Lince SL，Van Kempen LC，Vierhout ME，et al. A systematic review of clinical studies on hereditary factors in pelvic organ prolapse ［J］. Int Urogynecol J，2012，23(10): 1327-1336.
［6］Allen-Brady K，Norton PA，Farnham JM，et al. Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21 ［J］. Am J Hum Genet，2009，84(5): 678-682.
［7］Allen-Brady K，Cannon-Albright LA，Farnham JM，et al. Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17［J］. Am J Obstet Gynecol，2015，212(6): 771.e1-771.e7.
［8］Allen-Brady K，Cannon-Albright L，Farnham JM，et al. Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis ［J］. Obstet Gynecol，2011，118(6): 1345-1353.
［9］XIE Jing，WANG Chunli，HUANG Dong-yue，et al. TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury ［J］. J Biomech，2013，46(5): 890-898.
［10］Dos Santos RGM，Pepicelli FCA，Batista NC，et al. Collagen XVIII and LOXL-4 polymorphisms in women with and without advanced pelvic organ prolapse［J］. Int Urogynecol J，2018，29(6): 893-898.
［11］Giri A，Wu JM，Ward RM，et al. Genetic determinants of pelvic organ prolapse among African American and Hispanic women in the women's health initiative［J］. PLoS One，2015，10(11): e 0141647.
［12］Nikolova G，LEE Hane，Berkovitz S，et al. Sequence variant in the laminin gamma 1 (LAMC 1) gene associated with familial pelvic organ prolapse ［J］. Hum Genet，2007，120(6): 847-856.
［13］Nakad B，Fares F，Azzam N，et al. Estrogen receptor and laminin genetic polymorphism among women with pelvic organ prolapse［J］. Taiwan J Obstet Gynecol，2017，56(6): 750-754.
［14］Cartwright R，Kirby AC，Tikkinen KA，et al. Systematic review and meta analysis of genetic association studies of urinary symptoms and prolapse in women［J］. Am J Obstet Gynecol，2015，212(2): 199.e1-199.24.
［15］翟琳．LOXL1基因多态性及β-catenin表达与盆腔脏器脱垂的关系 ［D］．长春：吉林大学，2014．
［16］Khadzhieva MB，Kamoeva SV，Chumachenko AG，et al. Fibulin-5 (FBLN5) gene polymorphism is associated with pelvic organ prolapse ［J］. Maturitas，2014，78(4): 287-292.
［17］Wu JM，Visco AG，Grass EA，et al. Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse ［J］. Obstet Gynecol，2012，120 (3): 587-593.
［18］WANG Hong，ZHANG Zhi-qiang，WANG Shu-zhen，et al. Association of matrix metalloproteinase-10 polymorphisms with susceptibility to pelvic organ prolapse ［J］. J Obstet Gynaecol Res，2015，41(12): 1972-1981.
［19］Ward RM，Velez Edwards DR，Edwards T，et al. Genetic epidemiology of pelvic organ prolapse: a systematic review［J］. Am J Obstet Gynecol，2014，211(4): 326-335.
［20］艾比布汗·阿布来孜，古丽娜·阿巴拜克力，万晓慧.新疆维吾尔族、汉族女性盆腔器官脱垂患者雌激素受体SNP位点差异性分析 ［J］．新疆医科大学学报，2017,40（3）：293-296.
［21］XIE Ruoyun，XU Ying，FAN Shuixiu，et al. Identification of differentially expressed genes in pelvic organ prolapse by RNA-Seq ［J］. Med Sci Monit，2016，22: 4218-4225.
［22］戴毓欣，郎景和，朱兰，等．基因表达谱芯片在盆腔器官脱垂发病相关基因检测中的应用 ［J］．中华妇产科杂志，2010，45（5）：342-347．
［23］王真，史宏晖，陈娟，等．经典Wnt信号传导通路在盆腔器官脱垂发病中的作用 ［J］．中华医学杂志，2012，92（24）：1669-1672．
［24］朱军义．盆腔器官脱垂患者Wnt 16和FZD 5蛋白的异常变化［J］．中国现代医学杂志，2014，24（20）：101-103．
［25］RAO Shuquan，LANG Jinghe，ZHU Lan，et al. Exome sequencing identifies a novel gene，WNK1，for susceptibility to pelvic organ prolapse (POP)［J］. PLoS One，2015，10(3): e0119482.
［26］Serysheva E，Mlodzik M，Jenny A. WNKs in Wnt/β-catenin signaling ［J］. Cell Cycle，2014，13(2): 173-174.
［27］Jakus IA，Jakus D，Aracic N，et al. Immunohistochemical expression of hypoxia-inducible factor-1α in stromal cells of vaginal tissue in post-menopausal women with pelvic organ prolapse ［J］. Indian J Med Res，2017，146(Suppl): S 63-S 67.
［28］Kim JY，Kim EJ，Jeon MJ，et al. Association between the poly(ADP-ribose) polymerase-1 gene polymorphism and advanced pelvic organ prolapse ［J］. Menopause，2014，21(2): 177-181.
相似文献/References:
[1]胡鸣,洪莉,洪莎莎,等.人子宫旁韧带成纤维细胞机械力作用下线粒体形态与细胞衰老的研究[J].中国计划生育和妇产科,2015,(04):0.
HU Ming,HONG Li,HONG Sha-sha,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(5):0.
[2]陈翠兰.产后早期盆底肌康复治疗对产妇近期盆底功能的影响[J].中国计划生育和妇产科,2015,(11):0.
CHEN Cui-lan,[J].Chinese Journal of Family Planning & Gynecotokology,2015,(5):0.
[3]姜卫国,袁苗,王京晨,等.女性性功能障碍的康复治疗[J].中国计划生育和妇产科,2016,(08):0.
[4]陈瑾*,韩磊,张兰梅.腹横肌与盆底肌同步收缩锻炼对围绝经期妇女
压力性尿失禁的影响[J].中国计划生育和妇产科,2018,(3):41.
CHEN Jin*,HAN Lei,ZHANG Lan-mei.Effect of co-contraction of transverse abdominal and pelvic floor muscle exercises on stress urinary incontinence of peri-menopausal women[J].Chinese Journal of Family Planning & Gynecotokology,2018,(5):41.
[5]毛萌,朱兰*.组织工程技术在盆底重建手术中应用的最新进展[J].中国计划生育和妇产科,2018,(11):19.
[6]王莹莹,王君敏,陈璐璐,等.Wnt/β-catenin信号通路及WNK 1基因在盆腔脏器脱垂发病机制中的作用[J].中国计划生育和妇产科,2019,(5):56.
WANG Ying-ying,WANG Jun-min,CHEN Lu-lu,et al.The role of Wnt/β-catenin signaling pathways and WNK 1 in the pathogenesis of pelvic organ prolapse[J].Chinese Journal of Family Planning & Gynecotokology,2019,(5):56.
[7]陶有平,王翠翠,徐应利,等.全子宫切除术后重建宫颈阴道环对预防盆底脏器脱垂的临床疗效观察[J].中国计划生育和妇产科,2021,(7):55.[doi:10.3969/j.issn.1674-4020.2021.07.17]
Observation on the clinical effect of reconstruction of cervix-vaginal ring after total hysterectomy on prevention of pelvic floor organ prolapse[J].Chinese Journal of Family Planning & Gynecotokology,2021,(5):55.[doi:10.3969/j.issn.1674-4020.2021.07.17]