[1]赵振钏*,亓蓉,吴小华,等.卵巢刺激慢反应患者补充生长激素的疗效评价[J].中国计划生育和妇产科,2019,(7):41-44,59.
　ZHAO Zhen-chuan*,QI Rong,WU Xiao-hua,et al.Efficacy evaluation of supplementation of growth hormone in patients with suboptimal ovarian response[J].Chinese Journal of Family Planning & Gynecotokology,2019,(7):41-44,59.
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卵巢刺激慢反应患者补充生长激素的疗效评价
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年7期
页码:
41-44,59
栏目:
论著与临床
出版日期:
2019-06-25

文章信息/Info

Title:
Efficacy evaluation of supplementation of growth hormone in patients with suboptimal ovarian response
作者:
赵振钏*; 亓蓉; 吴小华; 周莉; 梁莹; 王娟
石家庄市第四医院生殖中心
Author(s):
ZHAO Zhen-chuan*; QI Rong; WU Xiao-hua; ZHOU Li; LIANG Ying; WANG Juan
Department of Reproductive Medicine, Fourth Hospital of Shijiazhuang City, Shijiazhuang Hebei 050000，P.R.China
关键词:
控制性超促排卵; 卵巢慢反应; 体外受精-胚胎移植; 生长激素
Keywords:
controlled ovarian hyperstimulation;  suboptimal ovarian response;  in vitro fertilization-embryo transfer;  growh hormone
分类号:
R 7137
摘要:
目的探讨在体外受精-胚胎移植(in vitro fertilization-embryo transfer，IVF-ET)中对卵巢刺激慢反应患者补充生长激素（growth hormone，GH）的疗效。方法选取2014年6月至2017年12月在石家庄市第四医院生殖中心接受IVF-ET治疗的患者130例，采用常规长方案，促性腺激素（gonadotropins，Gn）使用后第6～8 d阴道B超监测卵泡发育情况，并检测血清黄体生成素（luteinizing hormone，LH）、卵泡刺激素（follicle-stimulating hormone，FSH）、雌二醇（estradiol，E2）、孕酮（progesterone，P）水平。所有患者均符合卵巢慢反应（suboptimal ovarian response，SOR）标准，根据患者用药不同分为两组，研究组（72例）在添加尿促性素（human menopausal gonadotropin， HMG）同时加用GH 45 IU/d至绒毛膜促性腺激素（human choionic gonadotophin，hCG）日；对照组(68例)只添加HMG。分析两组临床资料和妊娠结局。结果两组患者年龄、体质量指数、Gn启动日LH、FSH及E2水平、窦卵泡数目、hCG日子宫内膜厚度方面比较，差异均无统计学意义（P>005）。研究组Gn使用天数、Gn使用量及HMG使用量低于对照组，获卵数目及受精数高于对照组，差异均有统计学意义（P<005）；研究组卵裂数、hCG日E2水平、优胚数及妊娠率均高于对照组，但差异无统计学意义（P>005）。结论SOR患者添加GH可减少Gn用量、Gn使用天数及HMG用量，增加获卵数及受精数。
Abstract:
ObjectiveTo investigate the effect of supplementation of growth hormone (GH) on patients with suboptimal ovarian response（SOR）in in vitro fertilization and embryo transfer (IVF-ET). MethodsFrom June 2014 to December 2017, 130 patients were treated with IVF-ET in the reproductive center of the Fourth Hospital of Shijiazhuang City, all patients were treated with conventional long prescription, and the development of follicular was monitored by vaginal ultrasound after gonadotropins (Gn) administration 6~8 days, and the levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P) were tested. All patients met the criteria of SOR. They were divided into two groups according to different medications. The study group (72 cases) was treated with human menopausal gonadotropin (HMG) and GH 45 IU/d to the day of human chorionic gonadotropin (hCG) administration, while the control group (68 cases) was only treated with HMG. The clinical data and pregnancy outcomes of the two groups were analyzed. ResultsThere were no significant differences in age, body mass index, LH, FSH and E2 levels on Gn initiation day, number of sinus follicles and endometrial thickness in the day of hCG administration between the two groups (P>005). The days of Gn, the total dosages of Gn and HMG in the study group were lower than those in the control group, and the number of eggs obtained and fertilized were higher than those in the control group (P<005); the cleavage number, E2 level in the day of hCG administration, number of good embryos and pregnancy rate in the study group were higher than those in the control group, but there were no significant statiscal difference (P>005). ConclusionAdding GH to SOR patients can reduce the dosage of Gn and HMG, the days of Gn used and increase the number of eggs and fertilization.

参考文献/References:

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备注/Memo

备注/Memo:
石家庄市科技局科技支撑计划（项目编号：141462893）
更新日期/Last Update: 2019-07-25