[1]李素廷,洪莉*,汤剑明,等.模拟产伤法构建小鼠肛提肌损伤模型及效果评价[J].中国计划生育和妇产科,2019,(10):88-91.
 LI Su-ting,HONG Li*,TANG Jian-ming,et al.Establish and evaluate the levator ani muscle damage of mouse by simulated birth injury[J].Chinese Journal of Family Planning & Gynecotokology,2019,(10):88-91.
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模拟产伤法构建小鼠肛提肌损伤模型及效果评价
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年10期
页码:
88-91
栏目:
论著与临床
出版日期:
2019-10-25

文章信息/Info

Title:
Establish and evaluate the levator ani muscle damage of mouse by simulated birth injury
作者:
李素廷洪莉*汤剑明闵洁胡鸣王琳琳卢丹华陈乾孙羽
武汉大学人民医院妇产科
Author(s):
LI Su-ting HONG Li*TANG Jian-mingMIN Jie HU Ming WANG Lin-linLU Dan-huaCHEN QianSUN Yu
Department of Obstetrics and Gynecology, People’s Hospital of Wuhan University, Wuhan Hubei 430060, P.R.China
关键词:
阴道扩张远端牵引肛提肌损伤动物模型
Keywords:
vaginal dilatationdistal tractionlevator ani muscle injurymouse modle
分类号:
R 711.4
摘要:
目的探索有效的小鼠肛提肌损伤模型构建方法。方法于2018年8~11月,选取40只SPF级雌性未孕未生育C57BL/6小鼠为研究对象。随机将小鼠分为假手术对照组、单纯阴道扩张组、阴道扩张+远端牵引10 g组、阴道扩张+远端牵引30 g组、阴道扩张+远端牵引60 g组,每组8只,共5组。在损伤24 h后固定小鼠肛提肌,通过HE染色及透射电镜扫描技术分析比较各处理条件下的损伤情况。结果HE染色结果显示:与对照组相比,单纯阴道扩张小鼠肛提肌组织未见明显损伤;阴道扩张+10 g砝码牵引1 h组肛提肌肌间隙略增大,组
Abstract:
ObjectiveTo explore the feasible method to construct a mouse model of levator ani muscle (LAM) injury.MethodsFrom August to November 2018, 40 SPF non-pregnant female C57BL/6 mice were selected. Mice were randomly divided into 5 groups, control group (CON)

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(项目编号:81771562)
更新日期/Last Update: 2019-10-25