[1]李亚梅,杨星宇,赵雪娅,等.早发型和晚发型子痫前期自噬与凋亡水平差异 及相互关系研究[J].中国计划生育和妇产科,2019,(11):38-43.
　LI Ya-mei,YANG Xing-yu,ZHAO Xue-ya,et al.The differences and interrelation of trophoblastic autophagy and apoptosis between early and late-onset preeclampsia[J].Chinese Journal of Family Planning & Gynecotokology,2019,(11):38-43.
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早发型和晚发型子痫前期自噬与凋亡水平差异 及相互关系研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年11期
页码:
38-43
栏目:
论著与临床
出版日期:
2019-11-25

文章信息/Info

Title:
The differences and interrelation of trophoblastic autophagy and apoptosis between early and late-onset preeclampsia
作者:
李亚梅; 杨星宇; 赵雪娅; 程蔚蔚*
上海交通大学医学院附属国际和平妇幼保健院妇产科,上海市胚胎源性疾病重点实验室，上海市临床重点专科（建设项目）-“强主体”妇产科
Author(s):
LI Ya-mei; YANG Xing-yu; ZHAO Xue-ya; CHENG Wei-wei*
Department of Obstetrics and Gynecology,The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine； Shanghai Key Laboratory of Embryo Original Diseases；Shanghai Municipal Key Clinical Specialty, Shanghai
关键词:
自噬; 凋亡; 滋养层细胞; 早发型子痫前期; 晚发型子痫前期
Keywords:
autophagy;  apoptosis;  trophoblasts;  early-onset preeclampsia;  late-onset preeclampsia
分类号:
R 714.24+5
摘要:
目的探讨早发型子痫前期（early-onset preeclampsia, EOPE）和晚发型子痫前期（late-onset preeclampsia, LOPE）胎盘组织中自噬和凋亡水平的差异，利用人绒毛膜滋养层细胞株HTR 8/SVneo缺氧模型探讨自噬与凋亡的关系，为解释子痫前期（preeclampsia, PE）的发病机制提供新的思路。方法选取2018年1~6月上海交通大学医学院附属国际和平妇幼保健院产科剖宫产分娩孕妇26例的临床资料。按照 PE 发生程度分为 EOPE 组10例，LOPE 组6例
Abstract:
ObjectiveTo investigate the differences of trophoblastic autophagy and apoptosis between early-onset preeclampsia（EOPE）and late-onset preeclampsia（EOPE）and to explore the relationship between autophagy and apoptosis in the human trophoblast HTR 8/SVneo ce

参考文献/References:

［1］BROWN M A, MAGEE L A, KENNY L C, et al. The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice ［J］. Pregnancy Hypertension: an International Journal of Women's Cardiovascular Health, 2018,6(3): 291-310. ［2］TRANQUILLI A L, BROWN M A, ZEEMAN G G, et al. The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP) ［J］. Pregnancy Hypertension: an International Journal of Women's Cardiovascular Health, 2013, 3(1): 44-47. ［3］WU Fan, TIAN Fu-ju, LIN Yi. Oxidative stress in placenta: health and diseases ［J］. BioMed Research International, 2015,2015:293271. ［4］OH S Y, ROH C R. Autophagy in the placenta ［J］. Obstetrics & Gynecology Science, 2017, 60 (3): 241-259. ［5］KERR J F, WYLLIE A H, CURRIE A R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics ［J］. British Journal of Cancer, 1972, 26 (4): 239-257. ［6］STEEGERS E P, VON DADELSZEN P, DUVEKOT J J, et al. Pre-eclampsia ［J］. Lancet(London,England), 2010, 376 (9741): 631-644. ［7］VON DADELSZEN P, MAGEE L A, ROBERTS J M. Subclassification of preeclampsia ［J］. Hypertension in Pregnancy, 2003, 22 (2): 143-148. ［8］OUDEJANS C B, VAN DIJK M, OOSTERKAMP M A, et al. Genetics of preeclampsia: paradigm shifts ［J］. Human Genetics, 2007, 120 (5): 607-612. ［9］GAO Li, QI Hong-bo, KAMANA K C, et al. Excessive autophagy induces the failure of trophoblast invasion and vasculature: possible relevance to the pathogenesis of preeclampsia ［J］. Journal of Hypertension, 2015, 33 (1): 106-117. ［10］CHEN Baosheng, LONGTINE M S, NELSON D M. Hypoxia induces autophagy in primary human trophoblasts ［J］. Endocrinology, 2012, 153 (10): 4946-4954. ［11］YAMANAKA-TATEMATSU M, NAKASHIMA A, FUJITA N, et al. Autophagy induced by HIF1 alpha overexpression supports trophoblast invasion by supplying cellular energy ［J］. PLOS One, 2013, 8 (10): e76605. ［12］YU Z-q, NI T, HONG B, et al. Dual roles of Atg8-PE deconjugation by Atg4 in autophagy ［J］. Autophagy, 2012, 8 (6): 883-892. ［13］MIZUSHIMA N. Autophagy: process and function ［J］. Genes & Development, 2007, 21 (22): 2861-2873. ［14］KLIONSKY D J, ABELIOVICH H, AGOSTINIS P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes ［J］. Autophagy, 2008, 4(2): 151-175. ［15］DADAKHUJAEV S, NOH H S, JUNG E J, et al. The reduced catalase expression in TrkA-induced cells leads to autophagic cell death via ROS accumulation ［J］. Experimental Cell Research, 2008, 314 (17): 3094-3106. ［16］MARINO G, NISO-SANTANO M, BAEHRECKE E H. Self-consumption: the interplay of autophagy and apoptosis ［J］. Nature Reviews Molecular Cell Biology, 2014, 15 (2): 81-94. ［17］WANG Ai-lan, LIU Qing-cui, ZHANG Jin, et al. Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2/interleukin-10 and Bcl-2/Bax ［J］. International Journal of Clinical and Experimental Medicine, 2015, 8(9): 16301-16307. ［18］TANAKA A, JIN Yang, LEE S J, et al. Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death ［J］. American Journal of Respiratory Cell and Molecular Biology, 2012, 46 (4): 507-514. ［19］FENG Zhaohui, ZHANG Haiyan, LEVINE A J, et al. The coordinate regulation of the p53 and mTOR pathways in cells ［J］. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (23): 8204-8209. ［20］TUULI M G, LONGTINE M S, NELSON D M. Review: Oxygen and trophoblast biology——a source of controversy ［J］. Placenta, 2011, 32 (Suppl 2): S109-S118. ［21］TIAN Xiao-yu, MA Su-ling, WANG Ya-qi, et al. Effects of placental ischemia are attenuated by 1,25-Dihydroxyvitamin D treatment and associated with reduced apoptosis and increased autophagy ［J］. DNA and Cell Biology, 2016, 35 (2): 59-70.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（项目编号：81501256）；上海市卫生和计划生育委员会资助项目（项目编号：201640361）；徐汇区市卫生规划委员会重大疾病项目（项目编号：XHLHGG201805）
更新日期/Last Update: 2019-11-25