[1]黄巧瑶,吴小环,汪晨曦,等.辅助生殖技术助孕后子代出生缺陷风险：基于队列研究的Meta分析[J].中国计划生育和妇产科,2020,(5):69-76,84.
　HUANG Qiaoyao,WU Xiaohuan,WANG Chenxi,et al.Risk of birth defects in offspring after assisted reproductive technology: a Metaanalysis based on cohort studies[J].Chinese Journal of Family Planning & Gynecotokology,2020,(5):69-76,84.
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辅助生殖技术助孕后子代出生缺陷风险：基于队列研究的Meta分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年5期
页码:
69-76,84
栏目:
论著与临床
出版日期:
2020-05-25

文章信息/Info

Title:
Risk of birth defects in offspring after assisted reproductive technology: a Metaanalysis based on cohort studies
作者:
黄巧瑶1; 吴小环2; 汪晨曦1; 韦冰1; 许丽华1; 马天仲1*
广东医科大学附属医院，1.生殖医学中心；2.内科
Author(s):
HUANG Qiaoyao1;  WU Xiaohuan2;  WANG Chenxi1;  WEI Bing1;  XU Lihua1;  MA Tianzhong1*
1. Reproductive Medicine Center；2. Internal Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang Guangdong 524001，P.R.China
关键词:
辅助生殖技术; 出生缺陷; Meta分析
Keywords:
assisted reproductive technology (ART); birth defect;  Metaanalysis
分类号:
R 7155
摘要:
目的评估辅助生殖技术（assisted reproductive technology,ART）助孕对子代出生缺陷的影响。方法检索从建库到2018年8月在PubMed、Embase、Cochrane图书馆、Sinomed、CNKI、万方、维普数据库中满足预先纳入标准的队列研究，使用I2统计和Q检验评估研究之间的统计异质性，使用固定效应模型或随机效应模型估计总体组合的风险。结果本次最终纳入60项研究进行Meta分析，评估ART助孕后的子代730 756名和自然受孕（spontaneously conceived ,SC）的子代26 185 008名的出生缺陷风险。与SC子代相比，ART助孕后的子代出生缺陷风险高［RR=142,95 % CI（130156）］。排除异质性大的1项研究后，余下59项研究在限定部分条件后，其出生缺陷风险的变化如下,泌尿生殖器畸形［RR=149,95 % CI（140159）］,单胎畸形 ［RR=143 ,95 % CI（130158）］,亚洲地区［RR=152，95 % CI（128180）］，基于临床的研究 ［RR=136，95 % CI（121160）］，小样本量的研究［<500，RR=152，95 % CI（135172）］，分层分析后，ART助孕后的子代出生缺陷风险高于SC子代。结论ART助孕子代出生缺陷风险高于SC组，因此在ART助孕后必须进行严格产前筛查，以避免严重畸形儿的出生。
Abstract:
Objective To assess the impact of assisted reproductive technology (ART) on birth defects. MethodsRetrieve the cohort studies that meet the preinclusion criteria in the PubMed, Embase, Cochrane Library, Sinomed, CNKI, Wanfang, and Vip databases from the establishment of the database to August 2018, I2 statistics and Qtests were used to assess statistical heterogeneity between studies, and fixedeffects models or randomeffects models were used to estimate the overall portfolio risk. Results60 studies were finally included for a metaanalysis to assess the risk of birth defects in 730 756 offspring after ART and 26 185 008 offspring of spontaneously conceived (SC).Compared with SC offspring, the offspring after ART had a higher risk of birth defects ［RR=142,95% CI(130156)］. After excluding one study with large heterogeneity, the remaining 59 studies after a limited number of conditions, the risk of birth defects changes as follows: genitourinary malformation ［RR=149, 95% CI(140159)］, singleton malformation ［RR=143, 95% CI(1.301.58)］, Asia ［RR=152, 95% CI(128180)］, clinical research ［RR=136, 95% CI(121160)］ ,in a study with a small sample size ［<500, RR=152, 95% CI(135172)］, after stratified analysis, the risk of birth defects in ART offspring was higher than that in SC offspring. ConclusionThe risk of birth defects of ART offspring is higher than that of SC group, so strict prenatal screening must be performed after ART to avoid birth of severe deformity.

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备注/Memo

备注/Memo:
广东医科大学大学生创新实验项目（项目编号：SYZY006）
更新日期/Last Update: 2020-05-25