[1]尹红亚,刘会雪*,童重新,等.未足月胎膜早破合并绒毛膜羊膜炎孕妇外周血 miR-145表达及与Th 1/Th 2平衡的关系[J].中国计划生育和妇产科,2020,(3):79-83.
　YIN Hong-ya,LIU Hui-xue*,TONG Chong-xin,et al.Expression of miR-145 in peripheral blood of pregnant women with premature rupture of membranes and chorioamnionitis and its relationship with Th 1/Th 2 balance[J].Chinese Journal of Family Planning & Gynecotokology,2020,(3):79-83.
点击复制

未足月胎膜早破合并绒毛膜羊膜炎孕妇外周血 miR-145表达及与Th 1/Th 2平衡的关系
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年3期
页码:
79-83
栏目:
论著与临床
出版日期:
2020-03-25

文章信息/Info

Title:
Expression of miR-145 in peripheral blood of pregnant women with premature rupture of membranes and chorioamnionitis and its relationship with Th 1/Th 2 balance
作者:
尹红亚; 刘会雪*; 童重新; 何瑞芝; 高芳
河北省儿童医院妇产科
Author(s):
YIN Hong-ya;  LIU Hui-xue*;  TONG Chong-xin;  HE Rui-zhi;  GAO Fang
Department of Obstetrics and Gynecology, Hebei Children's Hospital, Shijiazhuang Hebei 050031，P.R.China
关键词:
未足月胎膜早破; 绒毛膜羊膜炎; miR-145; Th 1/Th 2
Keywords:
premature rupture of membranes;  chorioamnionitis;  miR-145;  Th1/Th2
分类号:
R 71425
摘要:
目的 探讨miR-145在未足月胎膜早破（preterm prelabor rupture of membranes, pPROM）合并绒毛膜羊膜炎（histological chorioamnionitis,HCA）孕妇外周血中表达情况，并分析其与Th 1/Th 2平衡的关系。方法 选取2018年3月至2019年4月河北省儿童医院因胎膜早破入院的pPROM孕妇50例作为研究组，根据是否发生HCA分为HCA组（17例）与无HCA组（33例），另选取正常妊娠孕妇34例作为对照组，采集静脉血，分离血浆及外
Abstract:
Objective To investigate the expression of miR-145 in peripheral blood of pregnant women with premature rupture of membranes (pPROM) combined with histological chorioamnionitis (HCA), and to analyze its relationship with Th1/Th2 balance.Methods 50 pregna

参考文献/References:

［1］曾文娟，黄启涛，王海臻，等．血清淀粉样蛋白A与未足月胎膜早破并发亚临床绒毛膜羊膜炎的关系研究 ［J］．中国实用妇科与产科杂志，2017，33（4）：414-417． ［2］高磊，刘晓巍，姜艳，等．未足月胎膜早破危险因素分析及对母婴结局的影响 ［J］．中国临床医生杂志，2019，47（2）：164-167． ［3］Park J W, Park K H, Kook S Y, et al.Immune biomarkers in maternal plasma to identify histologic chorioamnionitis in women with preterm labor ［J］.Archives of Gynecology and Obstetrics, 2019, 299(3): 725-732. ［4］Hoya M, Nagamatsu T, Fujii T, et al.Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice ［J］.American Journal of Reproductive Immunology, 2018, 79(3): 165-170. ［5］Guo Xin, Yu Lijin, Chen Min, et al.miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40 ［J］.Journal of Translational Medicine, 2016, 14(1): 211. ［6］中华医学会妇产科学分会产科学组．胎膜早破的诊断与处理指南(2015) ［J］．中华围产医学杂志，2015，18（3）：161-167． ［7］Bauman M D, Iosif A M, Smith S E, et al.Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring ［J］.Biological Psychiatry, 2014, 75(4): 332-341. ［8］Ghosh M K, Muller H K, Walker A M.Lactation-Based maternal educational immunity crosses MHC class I barriers and can impart Th1 immunity to Th2-Biased recipients ［J］.Journal of Immunology， 2017, 199(5): 1729-1736. ［9］Clark D A, Croitoru K.TH1/TH2,3 imbalance due to cytokine-producing NK,gammadelta T and NK-gammadelta T cells in murine pregnancy decidua in success or failure of pregnancy ［J］.American Journal of Reproductive Immunology, 2015, 45(5): 257-265. ［10］ 周美茜，蔡畅，董磊，等．胎膜早破外周血单个核细胞Th1/Th2免疫偏移的临床研究 ［J］．中华医院感染学杂志，2012，22（8）：1557-1560． ［11］Tian Tian, Qiu Ran, Qiu Xia.SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer ［J］.Oncotarget, 2018, 9(2): 2128-2139. ［12］Fang C Y, Chen Pei-yin, Ho D C, et al.miR-145 mediates the anti-cancer stemness effect of photodynamic therapy with 5-aminolevulinic acid (ALA) in oral cancer cells ［J］.Journal of the Formosan Medical Association, 2018, 117(8): 738-742. ［13］Zhang Jun-he, Du A L, Wang Li, et al.Episomal lentiviral Vector-Mediated miR-145 overexpression inhibits proliferation and induces apoptosis of human esophageal carcinomas cells ［J］.Recent Patents on Anti-Cancer Drug Discovery, 2016, 11(4): 453-460. ［14］Ayrapetyan M, Carola D, Lakshminrusimha S, et al.Infants born to mothers with clinical chorioamnionitis: a Cross-Sectional survey on the use of Early-Onset sepsis risk calculator and prolonged use of antibiotics ［J］.American Journal of Perinatology, 2019, 36(4): 428-433. ［15］Fan Linxia, Wang Xiaojun, Fan Linlan, et al.MicroRNA-145 influences the balance of Th1/Th2 via regulating RUNX3 in asthma patients ［J］.Experimental Lung Research, 2016, 42(8/10): 417-424.

相似文献/References:

[1]陈红,王涛.生物蛋白胶宫颈封堵术治疗早产胎膜早破的临床应用[J].中国计划生育和妇产科,2010,(06):0.
　CHEN Hong,WANG Tao.[J].Chinese Journal of Family Planning & Gynecotokology,2010,(3):0.
[2]秦江霞,贾金平,岳玉焕,等.未足月胎膜早破患者阴道菌群微生态的评价[J].中国计划生育和妇产科,2014,(02):0.
　QIN Jiang-xia,JIA Jin-ping,YUE Yu-huan,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[3]杜鹃,王雪姣.未足月胎膜早破的研究进展[J].中国计划生育和妇产科,2015,(04):0.
[4]彭菊兰,罗丽琼,鲁翠萍,等.降钙素原在胎膜早破患者中的诊治价值[J].中国计划生育和妇产科,2016,(03):0.
　PENG Ju-lan,LUO Li-qiong,LU Cui-ping,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(3):0.
[5]李霞*,郭海香.血清降钙素原联合白细胞介素-8检测在预测未足月胎膜早破合并绒毛膜羊膜炎中的应用价值[J].中国计划生育和妇产科,2016,(12):24.
　LI Xia*,GUO Hai-xiang.The application value of serum procalcitonin combined with interleukin-8 in predicting preterm premature rupture of membranes combined with chorioamnionitis[J].Chinese Journal of Family Planning & Gynecotokology,2016,(3):24.
[6]张勇*,刘德松,廖志,等.不同程度组织学绒毛膜羊膜炎对极早产儿的影响[J].中国计划生育和妇产科,2017,(9):48.
　ZHANG Yong*,LIU De-song,LIAO Zhi,et al.Effects of different degrees of histological chorioamnionitis on very preterm infants[J].Chinese Journal of Family Planning & Gynecotokology,2017,(3):48.
[7]郭秋云.胎膜早破孕妇阴道分泌物中降钙素原、 C-反应蛋白、肿瘤坏死因子α、白介素6用于预测绒毛膜羊膜炎的临床价值[J].中国计划生育和妇产科,2018,(9):24.
　GUO Qiu-yun.Clinical value of PCT,CRP,TNF-α and IL-6 in vaginal discharge of pregnant women with premature rupture of membranes to predict chorioamnionitis[J].Chinese Journal of Family Planning & Gynecotokology,2018,(3):24.
[8]高永妹,陆勤*,邓娟.动态检测血清降钙素原在小于36周胎膜早破孕妇预测亚临床绒毛膜羊膜炎的价值研究[J].中国计划生育和妇产科,2018,(11):55.
　GAO Yong-mei,LU Qin*,DENG Juan.Value of dynamic detection of procalcitonin for prediction of subclinical chorioamnionitis in pregnant women less than 36 gestational weeks with premature rupture of membranes[J].Chinese Journal of Family Planning & Gynecotokology,2018,(3):55.

备注/Memo

备注/Memo:
河北省医学科学研究课题计划（项目编号：20190784）
更新日期/Last Update: 2020-03-25