[1]彭翔云*,王岚,李秋萍.晚期上皮性卵巢癌肿瘤细胞减灭术后1年内复发影响因素分析[J].中国计划生育和妇产科,2020,(6):69-73.
　PENG Xiangyun*,WANG Lan,LI Qiuping.Analysis of factors influencing the recurrence of advanced epithelial ovarian cancer within one year after cytoreductive surgery[J].Chinese Journal of Family Planning & Gynecotokology,2020,(6):69-73.
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晚期上皮性卵巢癌肿瘤细胞减灭术后1年内复发影响因素分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年6期
页码:
69-73
栏目:
论著与临床
出版日期:
2020-06-25

文章信息/Info

Title:
Analysis of factors influencing the recurrence of advanced epithelial ovarian cancer within one year after cytoreductive surgery
作者:
彭翔云1*; 王岚2; 李秋萍2
1.广西壮族自治区南溪山医院妇科；2.桂林市人民医院妇科
Author(s):
PENG Xiangyun1*; WANG Lan2; LI Qiuping2
1.Department of Gynaecology,Nanxishan Hospital of Guangxi Zhuang Autonomous Region；2.Department of Gynaecology,GuiLin People's Hospital,Guilin Guangxi 541002,PRChina
关键词:
上皮性卵巢癌; 影响因素; Logistics分析
Keywords:
epithelial ovarian cancer; influencing factors; logistic analysis
分类号:
R 7136
摘要:
目的分析晚期上皮性卵巢癌肿瘤细胞减灭术（cytoreductive surgery，CRS）术后1年内复发的影响因素。方法回顾性分析2015年1月至2019年1月因上皮性卵巢癌在广西壮族自治区南溪山医院进行CRS治疗的244例患者的临床资料，根据CRS术后随访1年内是否出现复发进行分组，其中复发组（107例），非复发组（137例）。对两组的临床资料进行单因素分析及多因素Logistic分析，并采用ROC曲线分析各因素预测CRS术后复发效能。结果复发组与非复发组的年龄、妊娠次数、分娩次数、吸烟史、饮酒史、FIGO分期、分化程度、组织学类型、淋巴结转移情况等资料比较,差异无统计学意义（P＞005）。复发组与非复发组的腰围身高比、体质量指数、血清糖类抗原125（carbohydrate antigen 125,CA 125）、血清附睾蛋白4（human epididymis protein 4,HE 4）、血清白蛋白（serum albumin， Alb）资料比较，差异均有统计学意义（P＜005）。多因素Logistics分析显示CA 125≥200 u/mL、HE 4≥200 pmol/L、Alb≤35 g/L是上皮性卵巢癌CRS治疗术后1年内复发的危险因素（P＜005）。通过ROC曲线分析血清CA 125、HE 4、Alb指标预测上皮性卵巢癌CRS治疗术后1年内复发的截断值分别为26942 u/mL、29989 pmol/L、3165 g/L，灵敏度分别为7218 %、8368 %、7203 %，特异度分别为7042 %、9004 %、8162 %。结论术前血清CA 125、HE 4高表达、Alb水平过低均为上皮性卵巢癌晚期CRS术后1年内复发的危险因素。
Abstract:
ObjectiveTo analyze the factors influencing the recurrence of advanced epithelial ovarian cancer within one year after cytoreductive surgery （CRS）.MethodsThe clinical data of 244 patients with epithelial ovarian cancer treated by CRS in Nanxishan Hospital of Guangxi Zhuang Autonomous Region from January 2015 to January 2019 were analyzed retrospectively,the patients were divided into recurrence group (107 cases) and non recurrence group (137 cases) according to whether there was recurrence within one year after CRS. The clinical data of the two groups were analyzed by single factor analysis and multi factor Logistic analysis, and ROC curve was used to analyze various factors to predict the recurrence efficacy after CRS.ResultsThere were no significant differences in age, pregnancy times, delivery times, smoking history, drinking history, FIGO stage, differentiation degree, histological type, lymph node metastasis between the recurrent group and the non recurrent group (P＞005). There were significant differences in waisttoheight ratio, BMI, carbohydrate antigen 125（CA 125）, human epididymis protein 4（HE 4） and serum albumin（Alb） between the recurrent group and the non recurrent group (P＜005). Multivariate Logistic analysis showed that CA 125≥200 u/mL, HE 4≥200 pmol/L, Alb≤35 g/L were the risk factors of recurrence within one year after CRS treatment(P＜005). ROC curve analysis showed that the cutoff values of serum CA 125, HE 4, and Alb indexes to predict recurrence within 1 year after CRS treatment of epithelial ovarian cancer were 26942 u/mL, 29989 pmol/L, and 3165 g/L, respectively.The sensitivity was 7218 %,8368 % and 7203 % respectively.The specificity was 7042 %,9004 % and 8162 % respectively.ConclusionPreoperative high expression of serum CA 125 and HE 4, and low Alb levels are all risk factors for recurrence of epithelial ovarian cancer within 1 year after CRS.

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备注/Memo:
广西壮族自治区卫生和计划生育委员会自筹经费科研课题（项目编号：Z 20180800）
更新日期/Last Update: 2020-06-25