[1]周剑利*,刘聪慧,邢军.妊娠期糖尿病患者血脂水平的变化对妊娠结局的影响[J].中国计划生育和妇产科,2016,(6):10-13.
　ZHOU Jian-li*,LIU Cong-hui,XING Jun.Effect of blood lipids levels on pregnancy outcomes in patients with gestational diabetes mellitus[J].Chinese Journal of Family Planning & Gynecotokology,2016,(6):10-13.
点击复制

妊娠期糖尿病患者血脂水平的变化对妊娠结局的影响
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2016年6期
页码:
10-13
栏目:
论著与临床
出版日期:
2016-06-25

文章信息/Info

Title:
Effect of blood lipids levels on pregnancy outcomes in patients with gestational diabetes mellitus
作者:
周剑利*; 刘聪慧; 邢军
华北理工大学附属医院妇产科
Author(s):
ZHOU Jian-li*;  LIU Cong-hui;  XING Jun
Department of Obstetric and Gynaecology, Affiliated Hospital of North China University Of Science And Technology, Tangshan Hebei 063000 ，P．R．China
关键词:
妊娠期糖尿病; 血脂; 妊娠结局
Keywords:
gestational diabetes mellitus; blood lipids level; pregnancy outcome
分类号:
R 714256
摘要:
目的探讨妊娠期糖尿病(gestational diabetes mellitus, GDM）孕妇血脂的变化在GDM发病中的作用和与妊娠结局的关系。方法选取2014年于华北理工大学附属医院妇产科分娩的250例患者的临床资料，分为GDM组92例和正常对照组158例,根据GDM组孕妇甘油三酯（triglyceride，TG）是否异常分为血脂异常亚组(33例)和血脂正常亚组(59例)。测定分娩前血脂水平，并对妊娠结局进行对比分析。 结果GDM组TG和载脂蛋白B（apolipoprotein B,ApoB）均高于正常对照组，GDM组低密度脂蛋白胆固醇（(low density lipoprotein cholesterol，LDL-C）低于正常对照组（P＜005）。新生儿体重与孕前体质量指数（body mass index，BMI）、孕期增重指数、TG和ApoB均呈明显的正相关（P＜005）。GDM组剖宫产率、巨大儿发生率和新生儿低血糖发生率均高于正常对照组，差异有统计学意义（P＜005），胎膜早破、早产和新生儿窒息发生率两组比较差异无统计学意义（P＞005）。血脂异常亚组中巨大儿的发生率高于血脂正常组（P＜005），其余妊娠结局两个亚组差异无统计学意义（P＞005）。结论GDM患者孕晚期存在高脂血症，与不良妊娠结局有关，TG水平与新生儿体重呈正相关，因此加强孕妇饮食指导和血脂监测有重要的临床意义。
Abstract:
ObjectiveTo detect blood lipids levels in patients with gestational diabetes mellitus(GDM) and explore the role in pathogenesis of GDM and the effect on pregnancy outcomes. Methods250 pregnant women who delivered in Affiliated Hospital of North China University Of Science And Technology were divided into to GDM group (92 cases) and control group (158 cases). According to the level of triglyceride （TG）, the GDM group was divided into lipid disorder subgroup and normal lipid subgroup.Blood lipid levels were detected and the pregnancy outcomes were recorded and compared. ResultsThe level of TG and apolipoprotein B (AopB) in GDM group was significantly higher than those in control group (P<005) ，the level of low density lipoprotein cholesterol( LDL-C) was significantly lower than that in control group (P<005). The birth weight had a significant positive correlation with pre-pregnancy body mass index (BMI)， the change of BMI during pregnancy, TG and ApoB(P<005). The rate of cesarean section， incidences of macrosomia，neonatal hypoglycemia in GDM group were significantly higher than those in control group (P<005). There was no significant difference in the incidences of premature rupture of membrane，premature delivery and neonatal asphyxia between the two groups(P>005).The incidence of macrosomia in lipid disorder subgroup was significantly higher than that in normal lipid subgroup in GDM group (P<005), there was no significant difference in other pregnancy outcomes between two subgroups. ConclusionThere was abnormal lipid metabolism in patients with GDM and the birth weight had a significant positive correlation with the level of TG.A dietary guide should be given to the pregnant patients and the monitoring of blood lipids levels is necessary.

参考文献/References:

［1］杨慧霞．2011年妊娠期糖尿病国际诊断标准解读 ［J］．中国医学前沿杂志（电子版）， 2011， 3 （4）： 19-20． ［2］虞斌，朱自强，黄瑞萍，等．妊娠期血脂变化及其特异性参考区间的建立 ［J］．山东医药， 2013， 53 （10）： 52-53． ［3］吕红娟，谢永红．C-反应蛋白、白细胞介素6与妊娠期糖尿病的胰岛素抵抗、血脂相关性研究 ［J］．中国妇幼保健， 2012， 27 （25）： 3892-3894． ［4］SANCHEZ-VERA I, BONET B, VIANA M, et al. Changes in plasma lipids and increased low-density lipoprotein susceptibility to oxidation in pregnancies complicated by gestational diabetes:Consequences of obesity ［J］, 2007， 56 （11）: 1527-1533. ［5］CHEN Dan-qing, ZHAO Hui-yun, FANG Qin, et al. Relationship between blood lipid levels of pregnant women with glucose metabolism disorders and perinatal outcomes ［J］. Zhonghua fu chan ke za zhi, 2007, 42 (6): 366-369. ［6］王纯，牛秀敏，韩姹．妊娠期糖尿病患者晚期血脂水平与围产结局 ［J］．中国妇幼保健， 2011， 26 （25）： 3875-3877． ［7］JOHNS K, OLYNIK C, MASE R, et al. Gestational diabetes mellitus outcome in 394 patients ［J］. Journal of Obstetrics and Gynaecology Canada : JOGC, 2006, 28 (2): 122-127. ［8］杨燕．妊娠期糖尿病患者血糖及血脂水平与新生儿体质量关系 ［J］．武汉大学学报（医学版）， 2011， 32 （5）： 665-667．

相似文献/References:

[1]程兰.妊娠期糖代谢异常患者血清胱抑素C测定的意义[J].中国计划生育和妇产科,2010,(06):0.
　CHENG Lan Tianjin Centtal Gynaecology and Obstetrics Hospital of,Tianjin 0000,China.[J].Chinese Journal of Family Planning & Gynecotokology,2010,(6):0.
[2]赵昆.D-二聚体测定在产科常见病理性高凝状态疾病的临床意义[J].中国计划生育和妇产科,2011,(04):0.
　ZHAO Kun.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(6):0.
[3]潘玥,刘巧,朱绍密,等.妊娠期糖尿病胰岛素治疗的临床分析[J].中国计划生育和妇产科,2011,(06):0.
　PAN Yue,LIU Qiao,ZHU Shao-mi.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(6):0.
[4]黎凤彩,苏凌春,曾志娟,等.血清胱抑素C联合血清尿酸在监测妊娠期糖尿病发生妊娠期高血压疾病的临床意义[J].中国计划生育和妇产科,2013,(05):0.
　LI Feng-cai,SU Ling-chun,ZENG Zhi-juan,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2013,(6):0.
[5]黄引平.子痫前期与代谢性疾病[J].中国计划生育和妇产科,2014,(01):0.
　HUANG Yin-ping,[J].Chinese Journal of Family Planning & Gynecotokology,2014,(6):0.
[6]王国育.妊娠期糖尿病孕妇孕前体质量指数对分娩方式和新生儿体质量的影响[J].中国计划生育和妇产科,2014,(07):0.
　WANG Guo-yu,[J].Chinese Journal of Family Planning & Gynecotokology,2014,(6):0.
[7]赵卓姝,关海兰,何洁云,等.孕期个性化营养指导对妊娠期糖尿病患者妊娠结局的影响[J].中国计划生育和妇产科,2014,(08):0.
　ZHAO Zhuo-shu,GUAN Hai-lan,HE Jie-yun,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(6):0.
[8]杨帆,官黄涛,刘太华,等.输精管结扎术对远期心血管疾病的高危因素影响的调查及分析[J].中国计划生育和妇产科,2014,(09):0.
　YANG Fan,GUAN Huang-tao,LIU Tai-hua,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(6):0.
[9]徐辉,姜群英,韦红梅,等.个性化营养干预对妊娠期糖尿病的治疗作用[J].中国计划生育和妇产科,2015,(01):0.
　XU Hui,JIANG Qun-ying,WEI Hong-mei,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(6):0.
[10]孙桢,黄立,夏勇,等.妊娠期糖尿病与核转录因子NF-κBp65相关性研究[J].中国计划生育和妇产科,2015,(04):0.
　SUN Zhen,HUANG Li,XIA Yong,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(6):0.
[11]杨金英,钟利若,刘晓英,等.小麦纤维素对妊娠期糖尿病患者血糖和血脂的影响研究[J].中国计划生育和妇产科,2015,(10):0.
　YANG Jin-ying,ZHONG Li-ruo,LIU Xiao-ying,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(6):0.
[12]周剑利,刘聪慧,邢军,等.妊娠期糖尿病患者血脂水平的变化对妊娠结局的影响[J].中国计划生育和妇产科,2016,(06):0.
　ZHOU Jian-li,LIU Cong-hui,XING Jun,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(6):0.
[13]李穗湘.妊娠期糖尿病患者晚孕期血脂水平检测的临床意义[J].中国计划生育和妇产科,2017,(2):68.
　LI Sui-xiang.Clinical significance of serum lipids detection in patients with gestational diabetes mellitus[J].Chinese Journal of Family Planning & Gynecotokology,2017,(6):68.
[14]刘婧*,程敬东,周英.1 941例妊娠期糖代谢异常孕妇血脂分析[J].中国计划生育和妇产科,2018,(3):50.
　LIU Jing*,CHENG Jing-dong,ZHOU Ying.Analysis of plasma lipids in 1 941 pregnant women with gestational diabetes mellitus[J].Chinese Journal of Family Planning & Gynecotokology,2018,(6):50.

更新日期/Last Update: 1900-01-01