[1]颜莉,龚莲,李爽.早发型重度子痫前期患者与慢性高血压并发早发型重度子痫前期患者的期待治疗时间与妊娠结局比较[J].中国计划生育和妇产科,2017,(3):61-64.
　YAN Li,GONG Lian,LI Shuang.The comparison of expectant treatment time and pregnancy outcome between patients with early-onset severe preeclampsia and patients with chronic hypertension complicated with early-onset severe preeclampsia[J].Chinese Journal of Family Planning & Gynecotokology,2017,(3):61-64.
点击复制

早发型重度子痫前期患者与慢性高血压并发早发型重度子痫前期患者的期待治疗时间与妊娠结局比较
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年3期
页码:
61-64
栏目:
论著与临床
出版日期:
2017-03-25

文章信息/Info

Title:
The comparison of expectant treatment time and pregnancy outcome between patients with early-onset severe preeclampsia and patients with chronic hypertension complicated with early-onset severe preeclampsia
作者:
颜莉; 龚莲; 李爽
宜宾市第一人民医院产科
Author(s):
YAN Li;  GONG Lian;  LI Shuang
Obstetrics of Yibin First People’s Hospital,Yibin Sichuan 644000,P.R.China
关键词:
早发型重度子痫前期; 期待治疗时间; 妊娠结局
Keywords:
early-onset severe preeclampsia;  expectant treatment time;  pregnancy outcome
分类号:
R 724+5
摘要:
目的比较无慢性高血压基础疾病的早发型重度子痫前期（early onset severe preeclampsia，EOSP）患者与慢性高血压并发EOSP患者的期待治疗时间和妊娠结局差异。方法选取2012~2015年宜宾市第一人民医院收治的EOSP患者420例，其中320例无慢性高血压基础病的EOSP患者为单纯组，100例慢性高血压并发EOSP患者为高血压组，比较两组的期待治疗时间和妊娠结局。结果高血压组最高收缩压、舒张压及胎儿生长受限发生率均较单纯组高，期待治疗时间比单纯组长，低蛋白血症及肺水肿发生率比单纯组低，差异均有统计学意义（P<005）；两组的胎盘早剥、HELLP综合征发生率、子痫发生率、围产儿死亡率、新生儿死亡率、胎死宫内发生率及新生儿窒息发生率等比较，差异无统计学意义（P＞005）。结论慢性高血压EOSP患者较无慢性高血压基础病的EOSP患者期待治疗时间长，但通过严密监测患者的病情，可获得较好的妊娠结局。
Abstract:
ObjectiveTo compare the expectant treatment time and pregnancy outcome between early onset severe preeclampsia(EOSP) with and without chronic hypertension. Methods420 patients with EOSP in Yibin First People's Hospital from January 2012 to December 2015 were divided into two groups. 320 EOSP patients without chronic essential hypertension were treated as the simple group while 100 patients with chronic hypertension complicated with EOSP as the hypertensive group. The expectant treatment time and pregnancy outcome were collected and analyzed. ResultsThe incidence of maximum systolic blood pressure, diastolic blood pressure and fetal growth restriction in the hypertension group was higher than that in the simple group, the expectant treatment time was longer and incidence of protein and pulmonary edema was lower than the simple group. The differences were statistically significant（P<005）. The differences between the two groups on the incidence of placental abruption, HELLP syndrome, eclampsia rate, perinatal mortality, neonatal mortality, intrauterine fetal death rate and incidence of neonatal asphyxia were not statistically significant(P>005). ConclusionEOSP in patients with chronic hypertension is expected to have a longer duration of treatment than patients without chronic hypertension. However, by closely monitoring the patient's condition, there is no significant difference in outcomes between the two groups.

参考文献/References:

［1］魏炜，王雅琴，徐晓辉，等．妊娠期高血压疾病性心脏病心力衰竭15例临床分析 ［J］．中国妇产科临床杂志，2016，17 （1）：40-44． ［2］党艳丽，张文颖，杜建新，等．慢性高血压合并早发型重度子痫前期引产后血栓形成一例 ［J］．中国妇产科临床杂志，2010，11 （2）：152-153． ［3］罗莉，陈江鸿．早发型重度子痫前期终止妊娠时机及分娩方式与围生儿结局的关系研究 ［J］．中国全科医学，2011，14 （3）：267-268, 271． ［4］AVANASI R, SHIN H, VIEIRA V, et al Variability and epistemic uncertainty in water ingestion rates and pharmacokinetic parameters, and impact on the association between perfluorooctanoate and preeclampsia in the C8 Health Project population ［J］. Environmental Research, 2016, 146 (4): 299-307. ［5］DURST J, TUULI M, STOUT M, et al. Degree of obesity at delivery and risk of preeclampsia with severe features ［J］. American Journal of Obstetrics and Gynecology, 2016, 214 (5): 651.e1-651.e5. ［6］黎秀娥．41例早发型重度子痫前期患者母婴结局 ［J］．中国妇幼保健，2009，17 （17）：2348-2349． ［7］甘竹，马红梅，兰红霞．早发型和晚发型重度子痫前期临床分析 ［J］．生殖医学杂志，2013，22 （11）：880-883． ［8］YLINIEMI A, NURKKALA M M, KOPMAN S A, et al. First trimester placental retinol-binding protein 4 (RBP4) and pregnancy-associated placental protein a (PAPP-A) in the prediction of early-onset severe pre-eclampsia ［J］. Metabolism-Clinical and Experimental, 2015, 64 (4): 521-526. ［9］杨孜．妊娠期高血压疾病分类及诊断的再认识 ［J］．实用妇产科杂志，2014，30 （6）：401-403． ［10］BUENO-SNCHEZ J, AGUDELO-JARAMILLO B, ESCOBAR-AGUILERAE L, et al. Cytokine production by non-stimulated peripheral blood NK cells and lymphocytes in early-onset severe pre-eclampsia without HELLP ［J］. Journal of Reproductive Immunology, 2013, 97 (2): 223-231. ［11］丁丹秋．重度子痫前期终止妊娠时机及结局的临床观察 ［J］．中国药物与临床，2015，15 （9）：1308-1309． ［12］CONNOLLY K, FACTOR S, GETRAJDMAN C, et al. Maternal clinical disease characteristics and maternal and neonatal outcomes in twin and singleton pregnancies with severe preeclampsia［J］. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2016, 201(5): 36-41. ［13］DOHERTY A, CARVALHO J, DREWLO S, et al. Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia ［J］. Journal of Obstetrics and Gynaecology Canada : JOGC, 2014, 36 (8): 692-700. ［14］TUTEN A, ONCUL M, KUCUR M, et al. Maternal serum copeptin concentrations in early- and late-onset pre-eclampsia ［J］. Taiwanese Journal of Obstetrics & Gynecology, 2015, 54 (4): 350-354.

相似文献/References:

[1]罗春艳,刘洁.早发型重度子痫前期39例临床特点分析[J].中国计划生育和妇产科,2012,(01):0.
　LUO Chun-yan,LIU Jie.[J].Chinese Journal of Family Planning & Gynecotokology,2012,(3):0.
[2]刘颖,李增彦.早发型重度子痫前期临床分析[J].中国计划生育和妇产科,2014,(02):0.
　LIU Ying,LI Zeng-yan,Tianjin Medical University,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[3]李卫文.早发型重度子痫前期患者的围产儿预后及影响因素分析[J].中国计划生育和妇产科,2015,(03):0.
　LI Wei-wen,[J].Chinese Journal of Family Planning & Gynecotokology,2015,(3):0.
[4]黄婷.早发型和晚发型重度子痫前期临床指标的对比研究[J].中国计划生育和妇产科,2017,(8):27.
　HUANG Ting.A comparative study of clinical indexes of early - onset and late - onset severe preeclampsia[J].Chinese Journal of Family Planning & Gynecotokology,2017,(3):27.
[5]徐红.拉贝洛尔对早发型重度子痫前期患者子宫螺旋动脉血流动力学及胎盘微血管密度的影响观察[J].中国计划生育和妇产科,2017,(9):41.
　XU Hong.Observation on the influence of labetalol on the uterine spiral artery hemodynamics and placental vascular density of patients with early-onset severe preeclampsia[J].Chinese Journal of Family Planning & Gynecotokology,2017,(3):41.
[6]赵丽娜,戴蕾,董武,等.趋化因子17与早发型重度子痫前期不良结局的相关性[J].中国计划生育和妇产科,2021,(2):47.
　[J].Chinese Journal of Family Planning & Gynecotokology,2021,(3):47.

更新日期/Last Update: 2017-03-25