[1]洪莉,李素廷,邢辉*.肌源性干细胞治疗女性压力性尿失禁的研究进展[J].中国计划生育和妇产科,2017,(7):17-20.
点击复制

肌源性干细胞治疗女性压力性尿失禁的研究进展
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年7期
页码:
17-20
栏目:
专题
出版日期:
2017-07-25

文章信息/Info

作者:
洪莉1; 李素廷1; 邢辉2*
1. 430060湖北武汉，武汉大学人民医院妇产科；2. 441021湖北襄阳，襄阳市中心医院妇产科
关键词:
压力性尿失禁; 干细胞治疗; 肌源性干细胞
分类号:
R 694+54
摘要:
女性压力性尿失禁（stress urinary incontinence，SUI）是指在腹压增加的情况下，膀胱压力超过尿道阻力，尿液不自主溢出的一种盆底功能障碍性疾病，尤以中老年女性多发。近年来，SUI发病率逐年增高，具体发病机制不明。现今主流观点认为尿道括约肌功能缺陷是造成SUI的原因之一，因此恢复括约肌的正常结构和生理功能成为SUI治疗的关键。肌源性干细胞（muscle derived stem cells, MDSCs）来源丰富，在体外无诱导因素作用下即可向肌细胞方向分化。相关研究认为MDSCs注射可以在一定程度上促进肌纤维的再生，恢复括约肌的功能。因此，MDSCs或许是干细胞治疗SUI的理想选择之一，推动MDSCs治疗SUI的科学研究及临床应用具有极其重要的意义。本文将从干细胞特点及应用、MDSCs在SUI治疗中的研究进展及其所面临的局限性进行综述。　　

参考文献/References:

［1］Kalejaiye O, Vij M, Drake MJ. Classification of stress urinary incontinence ［J］. World J Urol, 2015, 33(9): 1215-1220. ［2］Cervigni M, Gambacciani M. Female urinary stress incontinence［J］.Climacteric:the journal of the International Menopause Society, 2015,18(Suppl): 30-36. ［3］Wilkins MF, WU J-m. Lifetime risk of surgery for stress urinary incontinence or pelvic organ prolapse ［J］. Minerva Ginecol, 2017(69): 171-177. ［4］Jennifer MW, MD. Lifetime risk of stress incontinence or pelvic organ prolapse surgery ［J］. Obstet Gynecol, 2014, 123(6): 1201–1206. ［5］Minassian VA, SUN Haiyan, Yan XS, et al. The interaction of stress and urgency urinary incontinence and its effect on quality of Life ［J］. Int Urogynecol J, 2015, 26(2): 269-276. ［6］Lehmann C, Zipponi I, Baumann MU, et al. Standardized pelvic floor exercises improve stress urinary incontinence in women with intrinsic sphincter deficiency ［J］. Neurourol Urodyn, 2016, 35(6): 711-716. ［7］Herrera-Imbroda B, Lara MF, lzeta A, et al. Stress urinary incontinence animal models as a tool to study cell-based regenerative therapies targeting the urethral sphincter ［J］.Advanced Drug Delivery Reviews , 2015: 106–116. ［8］Fuoco C, Petrilli LL, Cannata S, et al. Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering ［J］. J Orthop Surg Res, 2016, 11(1): 86. ［9］Fu M-H, Li C-L, Lin H-L, et al. Stem cell transplantation therapy in Parkinson’s disease ［J］.SpringerPlus，2015，4:597. ［10］Meng, J. Autologous skeletal muscle derived cells expressing a novel functional dystrophin provide a potential therapy for Duchenne Muscular Dystrophy ［Z］. 2016: 19750. ［11］Dixit P, Katare R. Challenges in identifying the best source of stem cells for cardiac regeneration therapy ［J］. Stem Cell Res Ther, 2015, 6(1): 26. ［12］Lavasani M, Thompson SD, Pollett JB, et al. Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration ［J］. J Clin Invest, 2014, 124(4): 1745-1756. ［13］Barkholt L, Flory E, Jekerle V, et al. Risk of tumorigenicity in mesenchymal stromal cell-based therapies--bridging scientific observations and regulatory viewpoints ［J］. Cytotherapy, 2013, 15(7): 753-759. ［14］Zhang L, Wang W. Research progress in muscle-derived stem cells:Literature retrieval results based on international database ［J］.Neural Regeneration Research，2012，7(10):784-791. ［15］Lavasani M, Lu A, Thompson SD, et al. Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces ［J］. Methods Mol Biol, 2013, 976(8): 53-65. ［16］Pavyde E, Maciulaitis R, Mauricas M, et al. Skeletal Muscle-Derived Stem/Progenitor Cells: A Potential Strategy for the Treatment of Acute Kidney Injury ［J］. Stem Cells International， 2016，2016（3）:9618480. ［17］Bose B, Shenoy P S. Pluripotent conversion of muscle stem cells without reprogramming factors or small molecules stem cell Rev and rep ［Z］. 2016: 73. ［18］Nakajima N, Tamaki T, Hirata M, et al. Purified human skeletal muscle-derived stem cells enhance the repair and regeneration in the damaged urethra ［J］. Transplantation, 2016,88 (12). ［19］Tsao J, Kovanecz I, Awadalla N, et al. Muscle derived stem cells stimulate muscle myofiber repair and counteract fat infiltration in a diabetic mouse model of critical limb ischemia ［J］. J Stem Cell Res Ther, 2016, 6(12): 1000370. ［20］Vojnits K, PAN H, MU X, et al. Characterization of an injury induced population of Muscle-Derived stem Cell-Like cells ［Z］. 2015: 17355. ［21］Stangel-Wojcikiewicz K, Jarocha D, Piwowar M, et al. Autologous muscle-derived cells for the treatment of female stress urinary incontinence: a 2-year follow-up of a Polish investigation ［J］. Neurourol Urodyn, 2014, 33(3): 324-330. ［22］Stangel-Wojcikiewicz K, Piwowar M, Jach R, et al. Quality of Life assessment in female patients 2 and 4 years after muscle-derived cell transplants for stress urinary incontinence treatment ［J］. Ginekol Pol, 2016, 87(3): 183-189. ［23］Sharifiaghdas F, Tajalli F, Taheri M, et al. Effect of autologous muscle-derived cells in the treatment of urinary incontinence in female patients with intrinsic sphincter deficiency and epispadias: A prospective study ［J］. Int J Urol, 2016, 23(7): 581-586. ［24］Carr LK, Robert M, Kultgen PL, et al. Autologous muscle derived cell therapy for stress urinary incontinence: a prospective, dose ranging study ［J］. J Urol, 2013, 189(2): 595-601. ［25］Peters KM, Dmochowski RR, Carr LK, et al. Autologous muscle derived cells for treatment of stress urinary incontinence in women ［J］. J Urol, 2014, 192(2): 469-476. ［26］Kwon D, Kim Y, Pruchnic R, et al. Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence ［J］. Urology, 2006, 68(2): 449-454. ［27］Dissaranan C, Cruz MA, Couri BM, et al. Stem cell therapy for incontinence: where are we now? What is the realistic potential? ［J］. Curr Urol Rep, 2011, 12(5): 336-344. ［28］XU Y, SONG Y-f, LIN Z-x. Transplantation of muscle-derived stem cells plus biodegradable fibrin glue restores the urethral sphincter in a pudendal nerve-transected rat model ［J］. Brazilian Journal of Medical and Biological Research, 2010, 43(11): 1076-1083. ［29］Hakim L, De Ridder D, Van Der Aa F. Slings for urinary incontinence and the application of cell-based therapy ［J］. Adv Drug Deliv Rev, 2015, 60 (82-83): 22-30. ［30］Roman S, Mangera A, Osman NI, et al. Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse-which cell source? ［J］. Neurourol Urodyn, 2014, 33(5): 531-537. ［31］Villeda SA, LUO Jian, Mosher KI, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function ［J］. Nature, 2011, 477(7362): 90-94. ［32］Conboy IM, Rando TA. Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches ［J］. Cell Cycle, 2012, 11(12): 2260-2267. ［33］LIU Ling, Cheung TH, Charville GW, et al. Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging ［J］. Cell Rep, 2013, 4(1): 189-204. ［34］Kesireddy V. Evaluation of adipose-derived stem cells for tissue-engineered muscle repair construct-mediated repair of a murine model of volumetric muscle loss injury ［J］. Int J Nanomedicine, 2016, 11(default): 1461-1473. ［35］Kokai LE, Marra K, Rubin JP. Adipose stem cells: biology and clinical applications for tissue repair and regeneration ［J］. Translational Research, 2014, 163(4): 399-408. ［36］Boennelycke M, Gras S, Lose G. Tissue engineering as a potential alternative or adjunct to surgical Reconstruction in treating pelvic organ prolapse ［J］. Int Urogynecol J, 2013, 24(5): 741-747. ［37］Stangel-Wojcikiewicz K, Basta A, Piwowar M. Operative procedures supported withrobotics systems and available endoscope procedures in operative gynecology ［J］. Bio-AlgorithmsMed-Syst, 2014, 10 (3)：139-149.

相似文献/References:

[1]邵世清,韦业平.腹腔镜骶骨阴道固定术的疗效临床分析[J].中国计划生育和妇产科,2013,(03):0.
　SHAO Shi - Qing,WEI Ye - ping *.[J].Chinese Journal of Family Planning & Gynecotokology,2013,(7):0.
[2]闫梅,王晓银,温琦,等.不同产科因素对产后妇女盆底功能障碍的影响[J].中国计划生育和妇产科,2015,(08):0.
　YAN Mei,WANG Xiao-yin,WEN Qi,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(7):0.
[3]易念华,张艳,吴兰,等.中年妇女压力性尿失禁不同康复治疗方法疗效比较[J].中国计划生育和妇产科,2015,(11):0.
　YI Nian-hua,ZHANG Yan,WU Lan,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2015,(7):0.
[4]邓谋,朱兰.子宫内膜的再生及宫腔粘连干细胞修复的研究进展[J].中国计划生育和妇产科,2016,(03):0.
[5]苏晴,杨欣*.压力性尿失禁的术前检查[J].中国计划生育和妇产科,2017,(7):1.
[6]蒋妍,张琳,黄向华*.抗尿失禁手术前后残余尿测量的意义[J].中国计划生育和妇产科,2017,(7):7.
[7]万虹,陈德新*,庄琳,等.经阴道尿道中段线性悬吊术治疗压力性尿失禁 的疗效评价[J].中国计划生育和妇产科,2017,(7):34.
　WAN Hong,CHEN De-xin*,ZHUANG Lin,et al.Efficacy of transvaginal linear suspension in the middle of the urethra in the treatment of stress urinary incontinence[J].Chinese Journal of Family Planning & Gynecotokology,2017,(7):34.
[8]张静芳,胡海燕,李梅梅,等.三维经会阴超声对绝经后女性压力性尿失禁患者行无张力阴道吊带术的疗效评价[J].中国计划生育和妇产科,2017,(11):63.
　ZHANG Jing-fang,HU Hai-yan,LI Mei-mei,et al.Evaluation of the effect of three-dimensional perineal ultrasound on TVT-O in postmenopausal women with stress urinary incontinence[J].Chinese Journal of Family Planning & Gynecotokology,2017,(7):63.
[9]陈瑾*,韩磊,张兰梅.腹横肌与盆底肌同步收缩锻炼对围绝经期妇女 压力性尿失禁的影响[J].中国计划生育和妇产科,2018,(3):41.
　CHEN Jin*,HAN Lei,ZHANG Lan-mei.Effect of co-contraction of transverse abdominal and pelvic floor muscle exercises on stress urinary incontinence of peri-menopausal women[J].Chinese Journal of Family Planning & Gynecotokology,2018,(7):41.
[10]林晓杰.不同盆底肌肉锻炼时机对产后盆底功能的影响效果观察[J].中国计划生育和妇产科,2018,(7):37.
　LIN Xiao-jie.Effects of different training time of pelvic floor muscle training on postpartum pelvic floor function[J].Chinese Journal of Family Planning & Gynecotokology,2018,(7):37.
[11]闵洁 综述,洪莉 审校.压力性尿失禁新型非手术治疗的研究进展[J].中国计划生育和妇产科,2019,(1):21.

更新日期/Last Update: 2017-07-25