[1]李远梅,邹家群,蒋小娟,等.胎盘滋养细胞自噬的研究进展[J].中国计划生育和妇产科,2017,(8):9-12.
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胎盘滋养细胞自噬的研究进展
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年8期
页码:
9-12
栏目:
综述
出版日期:
2017-08-25

文章信息/Info

作者:
李远梅1邹家群1蒋小娟1 韩磊2*
1.400042重庆,第三军医大学大坪医院野战外科研究所乳腺甲状腺外科; 2.100101北京,解放军第306医院妇产科
关键词:
胎盘滋养细胞自噬子痫前期宫内生长受限
分类号:
R 329.2
摘要:
自噬是一种从酵母菌到哺乳动物细胞中均广泛存在的保守性细胞物质清除机制。在细胞和组织重塑、抵御细胞外刺激和病原体的过程中,细胞内组分可以转移到溶酶体中完成物质的新陈代谢,这对于维护细胞内稳态和物质、能量平衡都至关重要。本文主要探讨滋养细胞自噬在胎盘形成、孕早期滋养细胞缺氧、胚胎着床等过程中的重要作用,并阐述自噬及自噬相关基因与子痫前期及胎儿生长受限发生的相关性。

参考文献/References:

[1]LEVINE B, MIZUSHIMA N, VIRGIN H W. Autophagy in immunity and inflammation [J]. Nature, 2011, 469(7330): 323-335. [2]PRINGLE K G, KIND K L, SFERRUZZI-PERRI A N, et al. Beyond Oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy [J]. Human Reproduction Update, 2010, 16(4): 415-431. [3]AKAISHI R, YAMADA T, NAKABAYASHI K, et al. Autophagy in the placenta of women with hypertensive disorders in pregnancy [J]. Placenta, 2014, 35(12): 974-980. [4]蒋丽莎,窦国山,邹家群,等.自噬的细胞和分子生物学研究新进展 [J].解剖科学进展,2015,21(5):552-555. [5] Saito S, Nakashima A. Review: The role of autophagy in extravillous trophoblast function under hypoxia [J]. Placenta, 2013,34 Suppl:S 79-84. [6]许银燕,丁卉,张芬芬,等.滋养细胞自噬在子痫前期发病中的作用及其分子机制 [J].中华妇产科杂志,2013,48(10):759-762. [7]MYATT L. Reactive Oxygen and Nitrogen species and functional adaptation of the placenta [J]. Placenta, 2010, 31(A): S66-S69. [8]JAUNIAUX E, HEMPSTOCK J, TENG C, et al. Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: Maintenance of redox potential in a low Oxygen environment [J]. Journal of Clinical Endocrinology & Metabolism, 2005, 90(2): 1171-1175. [9]CHOI J H, LEE H J, YANG T-h, et al. Effects of hypoxia inducible factors-1alpha on autophagy and invasion of trophoblasts [J]. Clinical and Experimental Reproductive Medicine, 2012, 39(2): 73-80. [10]秦兴发,张华,漆洪波,等.缺氧诱导滋养细胞自噬参与子痫前期发病的实验研究 [J].重庆医学,2014,43(5):569-571. [11]NAKASHIMA A, YAMANAKA-TATEMATSU M, FUJITA N, et al. Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia [J]. Autophagy, 2013, 9(3): 303-316. [12]FANG Y, TAN Jin, ZHANG Qiang. Signaling pathways and mechanisms of hypoxia-induced autophagy in the animal cells [J]. Cell Biology International, 2015, 39(8): 891-898. [13]LI Meng-meng, TAN Jin, MIAO Yu-yang, et al. The dual role of autophagy under hypoxia-involvement of interaction between autophagy and apoptosis [J]. Apoptosis : an International Journal on Programmed Cell Death, 2015, 20(6): 769-777. [14]SIGNORELLI P, AVAGLIANO L, VIRGILI E, et al. Autophagy in term normal human placentas [J]. Placenta, 2011, 32(6): 482-485. [15]CHEN B, LONGTINE M S, NELSON D M. Hypoxia induces autophagy in primary human trophoblasts [J]. Endocrinology, 2012, 153(10): 4946-4954. [16]OH H A, KWON S, CHOI S, et al. Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos [J]. Molecular Human Reproduction, 2013, 19(2): 93-101. [17]LEE J E, OH H A, SONG H, et al. Autophagy regulates embryonic survival during delayed implantation [J]. Endocri-nology, 2011, 152 (5): 2067-2075. [18]Messai Y, Noman MZ, Janji B, et al. The autophagy sensor ITPR1 protects renal carcinoma cells from NK-mediated killing [J]. Autophagy, 2015. [19]YUE Zhenyu, JIN Shengkan, YANG C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor [J]. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(25): 15077-15082. [20]GAN B, PENG X, NAGY T, et al. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways [J]. The Journal of Cell Biology, 2006, 175(1): 121-133. [21]FIMIA G M, STOYKOVA A, ROMAGNOLI A, et al. Ambra1 regulates autophagy and development of the nervous system [J]. Nature, 2007, 447(7148): 1121-1125. [22]WOLF N, YANG W, DUNK C E, et al. Regulation of the matricellular proteins CYR61(CCN1)and NOV(CCN3)by hypoxia-inducible factor-1{alpha}and transforming-growth factor-{beta}3 in the human trophoblast [J]. Endocrinology, 2010, 151(6): 2835-2845. [23]DING Yan, CHOI M E. Regulation of autophagy by TGF-beta: emerging role in kidney fibrosis [J]. Seminars in Nephrology, 2014, 34 (1): 62-71. [24]HUNG T H, CHEN S-f, LO L M, et al. Increased autophagy in placentas of intrauterine growth-restricted pregnancies [J]. PLOS One, 2012, 7(7): e40957. [25]KOKLANARIS N, NWACHUKWU J C, HUANG S J, et al. First-trimester trophoblast cell model gene response to hypoxia [J]. American Journal of Obstetrics and Gynecology, 2006, 194(3): 687-693.

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备注/Memo

备注/Memo:
国家自然科学基金项目资助(项目编号:81401224)
更新日期/Last Update: 2017-08-25