[1]韩旭,王荣毓*.人乳头瘤病毒与宫颈病变的相关性 及危险因素分析[J].中国计划生育和妇产科,2017,(4):55-59.
　HAN Xu,WANG Rong-yu*.Correlation between human papillomavirus and cervical lesions andanalysis of risk factors[J].Chinese Journal of Family Planning & Gynecotokology,2017,(4):55-59.
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人乳头瘤病毒与宫颈病变的相关性 及危险因素分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年4期
页码:
55-59
栏目:
论著与临床
出版日期:
2017-04-25

文章信息/Info

Title:
Correlation between human papillomavirus and cervical lesions and analysis of risk factors
作者:
韩旭; 王荣毓*
北京市第一中西医结合医院妇科
Author(s):
HAN Xu;  WANG Rong-yu*
Department of Gynecology，Beijing First Hospital of Integrated Chinese and Western Medicine，Beijing 100026，P.R. China
关键词:
人乳头瘤病毒; 宫颈病变; 相关性分析; 危险因素
Keywords:
human papillomavirus;  cervical lesions;  correlation analysis;  risk factors
分类号:
R 711.74
摘要:
目的观察人乳头瘤病毒(human papillomavirus,HPV)与宫颈病变的相关性，并分析宫颈病变患者HPV感染的危险因素，为临床防治宫颈病变提供依据。方法以2013~2016年北京市第一中西医结合医院收治的120例宫颈病变和80例正常宫颈人群为研究对象，分析正常宫颈人群和不同类型宫颈病变患者的HPV感染差异，分析不同类型宫颈病变患者的HPV感染类型差异，并对宫颈病变患者HPV感染的危险因素进行分析。结果正常宫颈人群的HPV感染率(2125 %)显著低于宫颈上皮内瘤变（cervical intraepithelial neoplasia,CIN) Ⅰ型、CIN Ⅱ型、CIN Ⅲ型、宫颈腺癌、宫颈鳞癌及其他病变类型的宫颈病变患者的感染率(P<005)；CIN Ⅰ型、CIN Ⅱ型、CIN Ⅲ型、宫颈腺癌、宫颈鳞癌及其他病变类型的宫颈病变患者的单一型HPV感染率显著高于混合型HPV感染率(P<005)；年龄、文化程度和初次性生活年龄是宫颈病变患者HPV感染的独立危险因素。结论各种宫颈病变患者的HPV感染率高于正常人群，且病变程度越严重患者感染率越高，年龄、文化程度和初次性生活年龄是HPV感染的独立危险因素，临床防治宫颈病变应重视HPV对患者病情的影响。
Abstract:
ObjectiveTo observe the correlation between human papillomavirus (HPV) and cervical lesions, to analyze the risk factors of HPV infection in cervical lesions and to provide the basis for clinical prevention and treatment of cervical lesions. Methods120 cases of cervical lesions and 80 cases of normal cervix treated in Beijing First Hospital of Integrated Chinese and Western Medicine from January 2013 to December 2016 were selected. The differences of HPV infection between normal cervix and different types of cervical lesions were analyzed. The differences of HPV infection types among patients with different types of cervical lesions and risk factors of HPV infection in cervical lesions were also analyzed. ResultsThe infection rate of HPV in normal cervix (21.25%) was significantly lower than that in CINⅠ, CIN Ⅱ, CIN Ⅲ,cervical adenocarcinoma, cervical squamous cell carcinoma and other lesion types (P<005). The simple HPV infection rate of CIN Ⅰ, CIN Ⅱ, CIN Ⅲ, cervical adenocarcinoma, cervical squamous cell carcinoma and other lesion types was significantly higher than that of mixed HPV infection (P<005). Age, educational level and primary sex age are independent risk factors for HPV infection in cervical lesions.ConclusionHPV infection rate of patients with a variety of cervical lesions was higher than that of the general population,and the more severe lesions in patients the higher the infection rate. Age, educational level and primary sex age are independent risk factors of HPV infection. Clinical prevention and treatment of cervical lesions should pay attention to the effect of HPV on the condition of patients.

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备注/Memo

备注/Memo:
宫颈高危型人乳头瘤病毒感染人群的体质辨识研究以及体质干预防治体系的构建（项目编号：朝阳区科委2015CYSF1519）
更新日期/Last Update: 2017-04-25